GSDMD expression mediated by IRF2, IRF1

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R-HSA-9710294
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Reaction [omitted]
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Homo sapiens
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Gasdermin D (GSDMD), a key protein in the activation of pyroptosis, is expressed in a wide range of tissues and immune cells. The transcription factor interferon regulatory factor 2 (IRF2) was found to be essential for the transcriptional activation of GSDMD in human and mouse cells (Kayagaki N et al. 2019).

Literature References
PubMed ID Title Journal Year
31113851 IRF2 transcriptionally induces GSDMD expression for pyroptosis

Kayagaki, N, Lee, BL, Stowe, IB, Kornfeld, OS, O'Rourke, K, Mirrashidi, KM, Haley, B, Watanabe, C, Roose-Girma, M, Modrusan, Z, Kummerfeld, S, Reja, R, Zhang, Y, Cho, V, Andrews, TD, Morris, LX, Goodnow, CC, Bertram, EM, Dixit, VM

Sci Signal 2019
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