GSDMD expression mediated by IRF2, IRF1

Stable Identifier
R-HSA-9710294
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
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GSDMD expression mediated by IRF2, IRF1
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Gasdermin D (GSDMD), a key protein in the activation of pyroptosis, is expressed in a wide range of tissues and immune cells. The transcription factor interferon regulatory factor 2 (IRF2) was found to be essential for the transcriptional activation of GSDMD in human and mouse cells (Kayagaki N et al. 2019).

Literature References
PubMed ID Title Journal Year
31113851 IRF2 transcriptionally induces GSDMD expression for pyroptosis

Modrusan, Z, Bertram, EM, Reja, R, Mirrashidi, KM, Watanabe, C, O'Rourke, K, Stowe, IB, Lee, BL, Dixit, VM, Kayagaki, N, Zhang, Y, Cho, V, Kummerfeld, S, Goodnow, CC, Roose-Girma, M, Haley, B, Andrews, TD, Morris, LX, Kornfeld, OS

Sci Signal 2019
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
IRF2, IRF1:GSDMD gene [nucleoplasm] (Homo sapiens)
Active Unit
IRF2, IRF1 [nucleoplasm]
Authored
Shamovsky, V  (2020-11-09)
Reviewed
D'Eustachio, P  (2021-02-17)
Kanneganti, TD  (2021-02-17)
Shao, F  (2021-04-22)
Created
Shamovsky, V  (2020-12-28)
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