Reactome | PPIA [extracellular exosome]

PPIA [extracellular exosome]

Stable Identifier

R-HSA-6801538

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular exosome

Synonyms

Cyp A protein

Locations in the PathwayBrowser for interactor UniProt:P05067 APP

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External Reference Information

External Reference

UniProt:P62937 PPIA

Gene Names

PPIA, CYPA

Chain

chain:1-165, initiator methionine:1, chain:2-165

Reference Genes

BioGPS Gene:5478 P629372

COSMIC - genes:PPIA PPIA

CTD Gene:5478 P629372

dbSNP Gene:5478 PPIA

ENSEMBL:ENSG00000196262 PPIA

HGNC:9253 P629372

KEGG:hsa:5478 P629372

Monarch:5478 P629372

NCBI Gene:5478 P629372

OMIM:123840 P629372

UCSC:P62937 P629372

Reference Transcript

Participates

as an output of

Expression of Peptidyl-prolyl cis-trans isomerase A (Homo sapiens)

Other forms of this molecule

PPIA [cytosol]

PPIA [ficolin-1-rich granule lumen]

PPIA [extracellular region]

PPIA [secretory granule lumen]

Cross References

RefSeq

XP_054214491.1, NP_001287910.1, XP_047276493.1, NP_066953.1, XP_047276492.1

Guide to Pharmacology - Targets

2751

OpenTargets

ENSG00000196262

ENSEMBL

ENSP00000504735, ENSP00000504216, ENST00000678789, ENST00000355968, ENST00000468812, ENSP00000419425, ENST00000489459, ENSP00000430817, ENSP00000502945, ENSP00000503804, ENST00000677022, ENSP00000427976, ENST00000678805, ENSG00000196262, ENST00000677107

ZINC - Substances

PPIA_HUMAN

ZINC target

P62937

PRO

P62937

GlyGen

P62937

PDB

4YUK, 5WC7, 9BGB, 5KV2, 5NOX, 9BGD, 6GJM, 6U5C, 7UXJ, 2CPL, 1AWT, 2N0T, 9BFX, 4N1P, 9BFY, 5NOT, 1W8V, 2RMA, 1CWO, 3ODI, 6U5G, 6X4Q, 5NOZ, 4YUL, 3ODL, 1W8M, 9BFW, 8TBM, 1AWS, 1CWA, 5KUV, 5KUN, 9AX6, 5LUD, 4N1Q, 9BG5, 7ABT, 1MIK, 9BHO, 1MF8, 2X25, 5FJB, 6GJY, 1CWM, 1ZKF, 2XGY, 5KUO, 6X4P, 4YUG, 4YUJ, 2X2A, 9BGA, 2MS4, 5KUS, 7UXM, 1AWV, 5KV6, 3CYH, 8TBL, 8G9Q, 5NOR, 1CWH, 9BI2, 5KV1, 6X4O, 6Y9Z, 1RMH, 5NOW, 5F66, 2RMB, 3K0M, 3K0O, 5KUQ, 2X2C, 5NOY, 8TBF, 5KUL, 1AK4, 5KV4, 1AWU, 1CWB, 9BG7, 4N1O, 3CYS, 9BG4, 5NOU, 9BHQ, 6GJJ, 8HZ8, 6X4N, 1CWF, 5NOV, 3K0N, 4YUP, 1M9X, 7QBW, 1NMK, 1M9E, 5CYH, 1M9D, 4CYH, 4YUO, 8TBH, 3RDD, 1FGL, 8G9P, 7TA8, 9BG1, 9BFV, 1OCA, 1VBS, 4N1S, 4N1N, 1CWJ, 4YUH, 6Y9Y, 5T9U, 5KUR, 5KUZ, 3K0R, 9BG0, 1M9Y, 6GJL, 5T9W, 1YND, 7UPN, 1W8L, 5T9Z, 8TBK, 5KUU, 5TA4, 1CWC, 9BG6, 8TBI, 6I42, 5NOS, 1CWI, 4IPZ, 6X4M, 6Y9X, 5KV3, 6ZDJ, 4YUI, 5KV5, 1M9F, 2ALF, 2MZU, 4YUM, 1AWR, 5KV7, 7N9X, 6U5E, 6X3Y, 5NOQ, 9BFZ, 1BCK, 1M63, 2CYH, 1CWL, 9BG3, 9BG8, 9GHY, 3K0P, 9BI1, 5KV0, 6Y9W, 6GJR, 9BGC, 2X2D, 5TA2, 6GJN, 4YUN, 6GS6, 8TBJ, 1M9C, 1AWQ, 6GJP, 8TBN, 7UXN, 6U5D, 6X3R, 9BG9, 1VBT, 9BG2, 4N1R, 7PCJ, 8TBG, 4N1M, 1CWK, 6GJI, 6Y9V, 3K0Q, 9BHP, 5KUW, 6BTA

GeneCards

PPIA

HPA

ENSG00000196262-PPIA

Pharos - Targets

P62937

ZINC - Predictions - Purchasable

PPIA_HUMAN

HMDB Protein

HMDBP10691

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.713	3
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.676	4
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.666	4
UniProt:Q72497 Q72497			0.623	7
UniProt:P46108-1 CRK			0.595	4
UniProt:Q99IB8-PRO_0000045602			0.59	2
UniProt:P35613 BSG	2	BSG [plasma membrane] (R-HSA-197673) BSG [Golgi membrane] (R-HSA-204478)	0.589	2
UniProt:O14686 KMT2D	20	KMT2D R5471M [nucleoplasm] (R-HSA-9946506) KMT2D W5217R [nucleoplasm] (R-HSA-9946443) KMT2D H5059P [nucleoplasm] (R-HSA-9945069) KMT2D R5340Q [nucleoplasm] (R-HSA-9946447) KMT2D R3321* [nucleoplasm] (R-HSA-9949952) KMT2D E5425K [nucleoplasm] (R-HSA-9946502) KMT2D Y5510D [nucleoplasm] (R-HSA-9946521) KMT2D M999Yfs69 [nucleoplasm] (R-HSA-9949980) KMT2D K1885Qfs18 [nucleoplasm] (R-HSA-9949981) KMT2D G5189R [nucleoplasm] (R-HSA-9946430) KMT2D T5098P [nucleoplasm] (R-HSA-9946431) KMT2D R2635* [nucleoplasm] (R-HSA-9949939) KMT2D R3707* [nucleoplasm] (R-HSA-9949940) KMT2D R5027* [nucleoplasm] (R-HSA-9949941) KMT2D E5008* [nucleoplasm] (R-HSA-9949943) KMT2D L449Vfs5 [nucleoplasm] (R-HSA-9952106) KMT2D Q2004 [nucleoplasm] (R-HSA-9951082) KMT2D I1509Vfs6 [nucleoplasm] (R-HSA-9952107) KMT2D R1687Tfs4 [nucleoplasm] (R-HSA-9952109) KMT2D Q4230* [nucleoplasm] (R-HSA-9951085)	0.558	2
UniProt:O75376 NCOR1	2	NCOR1 [nucleoplasm] (R-HSA-442501) NCOR1 [cytosol] (R-HSA-1253310)	0.556	3
UniProt:O43614 HCRTR2	1	HCRTR2 [plasma membrane] (R-HSA-389421)	0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:P62841 RPS15	2	RPS15 [cytosol] (R-HSA-72335) RPS15 [nucleoplasm] (R-HSA-6798706)	0.556	3
UniProt:Q00535 CDK5	4	CDK5 [cytosol] (R-HSA-180064) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) p-Y15-CDK5 [cytosol] (R-HSA-399809) CDK5 [nucleoplasm] (R-HSA-8863586)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:O00429 DNM1L	2	DNM1L [cytosol] (R-HSA-351943) DNM1L [mitochondrial outer membrane] (R-HSA-351942)	0.527	5
UniProt:Q13618 CUL3	3	CUL3 [cytosol] (R-HSA-975979) CUL3 [nucleoplasm] (R-HSA-5635033) G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516)	0.527	2
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	3
UniProt:P0C6X7-PRO_0000037309 REP			0.508	4
UniProt:Q16849 PTPRN			0.508	3
UniProt:O00267 SUPT5H	1	p-SUPT5H [nucleoplasm] (R-HSA-3009372)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	12
UniProt:P01112 HRAS	20	S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912) HRAS [plasma membrane] (R-HSA-62717) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) proHRAS [cytosol] (R-HSA-9647765) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G13R [plasma membrane] (R-HSA-6802368)	0.483	2
UniProt:O95831 AIFM1			0.463	2