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OGG1 [nucleoplasm]
Stable Identifier
R-HSA-60887
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
N-glycosylase/DNA lyase (Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase)), N-glycosylase/DNA lyase, 8-oxoguanine DNA glycosylase , DNA-(apurinic or apyrimidinic site) lyase , AP lyase
Icon
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Base-Excision Repair, AP Site Formation (Homo sapiens)
Depurination (Homo sapiens)
Cleavage of the damaged purine (Homo sapiens)
Excision of 8-oxoguanine by OGG1 glycosylase (Homo sapiens)
OGG1 [nucleoplasm] (Homo sapiens)
OGG1:(8oxoG:Cyt)-dsDNA [nucleoplasm] (Homo sapiens)
OGG1 [nucleoplasm] (Homo sapiens)
OGG1:AP-dsDNA [nucleoplasm] (Homo sapiens)
OGG1 [nucleoplasm] (Homo sapiens)
Recognition and association of DNA glycosylase with site containing an affected purine (Homo sapiens)
OGG1 glycosylase mediated recognition and binding of an 8-oxoguanine opposite to a cytosine (Homo sapiens)
OGG1 [nucleoplasm] (Homo sapiens)
OGG1:(8oxoG:Cyt)-dsDNA [nucleoplasm] (Homo sapiens)
OGG1 [nucleoplasm] (Homo sapiens)
Depyrimidination (Homo sapiens)
Cleavage of the damaged pyrimidine (Homo sapiens)
Excision of FapyG by OGG1 glycosylase (Homo sapiens)
OGG1 [nucleoplasm] (Homo sapiens)
OGG1:AP-dsDNA [nucleoplasm] (Homo sapiens)
OGG1 [nucleoplasm] (Homo sapiens)
OGG1:FapyG-dsDNA [nucleoplasm] (Homo sapiens)
OGG1 [nucleoplasm] (Homo sapiens)
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Homo sapiens)
OGG1 glycosylase mediated recognition and binding of a formamidopyrimidine (FapyG) (Homo sapiens)
OGG1 [nucleoplasm] (Homo sapiens)
OGG1:FapyG-dsDNA [nucleoplasm] (Homo sapiens)
OGG1 [nucleoplasm] (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Homo sapiens)
NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Homo sapiens)
OGG1 [nucleoplasm] (Homo sapiens)
OGG1:AP-dsDNA [nucleoplasm] (Homo sapiens)
OGG1 [nucleoplasm] (Homo sapiens)
Displacement of DNA glycosylase by APEX1 (Homo sapiens)
Displacement of OGG1 glycosylase by APEX1 at the AP site (Homo sapiens)
OGG1 [nucleoplasm] (Homo sapiens)
OGG1:AP-dsDNA [nucleoplasm] (Homo sapiens)
OGG1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15527 OGG1
Gene Names
OGG1, MMH, MUTM, OGH1
Chain
chain:1-345
Reference Genes
BioGPS Gene:4968 OGG1
COSMIC (genes):OGG1 OGG1
CTD Gene:4968 OGG1
dbSNP Gene:4968 OGG1
ENSEMBL:ENSG00000114026 OGG1
HGNC:8125 OGG1
KEGG:hsa:4968 OGG1
Monarch:4968 OGG1
NCBI Gene:4968 OGG1
OMIM:601982 OGG1
UCSC:O15527 OGG1
Reference Transcript
RefSeq:NM_016820.3 OGG1
RefSeq:NM_016829.2 OGG1
RefSeq:NM_002542.5 OGG1
RefSeq:NM_016821.2 OGG1
RefSeq:NM_016827.2 OGG1
RefSeq:NM_016819.3 OGG1
RefSeq:NM_016828.2 OGG1
RefSeq:NM_016826.2 OGG1
Participates
as an output of
Displacement of OGG1 glycosylase by APEX1 at the AP site (Homo sapiens)
NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Homo sapiens)
as an input of
OGG1 glycosylase mediated recognition and binding of a formamidopyrimidine (FapyG) (Homo sapiens)
OGG1 glycosylase mediated recognition and binding of an 8-oxoguanine opposite to a cytosine (Homo sapiens)
as a component of
OGG1:FapyG-dsDNA [nucleoplasm] (Homo sapiens)
OGG1:AP-dsDNA [nucleoplasm] (Homo sapiens)
OGG1:(8oxoG:Cyt)-dsDNA [nucleoplasm] (Homo sapiens)
Other forms of this molecule
OGG1 R131G [nucleoplasm]
OGG1 R46L [nucleoplasm]
OGG1 P266fs*139 [nucleoplasm]
OGG1 R131Q [nucleoplasm]
OGG1 R229Q [nucleoplasm]
OGG1 R46Q [nucleoplasm]
OGG1 R154H [nucleoplasm]
OGG1 D268N [nucleoplasm]
SOH-C326-OGG1 S326C [nucleoplasm]
OGG1 D268A [nucleoplasm]
OGG1 K249Q [nucleoplasm]
OGG1 S326C [nucleoplasm]
OGG1 A288V [nucleoplasm]
OGG1 A53T [nucleoplasm]
Inferred To
ogg1 [nucleoplasm]
(Dictyostelium discoideum)
OGG1 [nucleoplasm]
(Bos taurus)
OGG1 [nucleoplasm]
(Canis familiaris)
OGG1 [nucleoplasm]
(Drosophila melanogaster)
OGG1 [nucleoplasm]
(Mus musculus)
OGG1 [nucleoplasm]
(Plasmodium falciparum)
OGG1 [nucleoplasm]
(Rattus norvegicus)
OGG1 [nucleoplasm]
(Saccharomyces cerevisiae)
Cross References
Guide to Pharmacology - Targets
3060
OpenTargets
ENSG00000114026
ENSEMBL
ENSP00000306561
,
ENSG00000114026
,
ENSP00000344899
,
ENSP00000305584
,
ENSP00000305527
,
ENST00000339511
,
ENSP00000342851
,
ENSP00000345520
,
ENST00000352937
,
ENST00000302008
,
ENSP00000373337
,
ENST00000449570
,
ENSP00000403598
,
ENST00000383826
,
ENST00000344629
,
ENST00000302036
,
ENST00000302003
IntEnz
4.2.99.18
GeneCards
OGG1
HPA
ENSG00000114026-OGG1
PRO
O15527
Pharos - Targets
O15527
PDB
1N39
,
1YQM
,
1YQK
,
1YQL
,
2XHI
,
1YQR
,
1N3A
,
6W0R
,
3KTU
,
6W13
,
3IH7
,
1HU0
,
2NOE
,
2NOH
,
8VX6
,
2NOI
,
2NOF
,
1M3H
,
1M3Q
,
2NOL
,
8VX4
,
2NOZ
,
2NOB
,
1N3C
,
6RLW
,
1KO9
,
1EBM
,
7AYY
,
6W0M
,
1LWV
,
1LWW
,
1LWY
,
5AN4
,
1FN7
,
2I5W
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