OGG1 D268N [nucleoplasm]

Stable Identifier
R-HSA-9663721
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
OGG1 Asp268Asn
Icon
OGG1 D268N [nucleoplasm] icon
OGG1 D268N [nucleoplasm] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
11902834 Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase

Pearl, LH, Seeberg, E, Bjørås, M, Luna, L, Barrett, TE

J. Mol. Biol. 2002
12578369 Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase

Norman, DP, Chung, SJ, Verdine, GL

Biochemistry 2003
28334993 The mechanism of the glycosylase reaction with hOGG1 base-excision repair enzyme: concerted effect of Lys249 and Asp268 during excision of 8-oxoguanine

Reha, D, Nencka, R, Tanaka, Y, Sato, D, Šebera, J, Hattori, Y, Kojima, C, Sychrovský, V, Kohno, T

Nucleic Acids Res. 2017
External Reference Information
External Reference
UniProt:O15527 OGG1
Gene Names
OGG1, MMH, MUTM, OGH1
Chain
chain:1-345
Reference Genes
BioGPS Gene:4968 OGG1
COSMIC (genes):OGG1 OGG1
CTD Gene:4968 OGG1
dbSNP Gene:4968 OGG1
ENSEMBL:ENSG00000114026 OGG1
ENSEMBL_homo_sapiens_GENE:ENSG00000114026.22 OGG1
HGNC:8125 OGG1
KEGG Gene (Homo sapiens):4968 OGG1
Monarch:4968 OGG1
NCBI Gene:4968 OGG1
OMIM:601982 OGG1
UCSC:O15527 OGG1
Reference Transcript
Other Identifiers
11727607_a_at
11727608_x_at
11727696_x_at
11740749_a_at
16937329
205301_PM_s_at
205301_s_at
205760_PM_s_at
205760_s_at
2609907
2609908
2609909
2609910
2609913
2609914
2609916
2609917
2609918
2609920
2609921
2609922
2609923
2609924
2609925
2609926
2609927
2609929
2609930
2609931
34146_at
34147_g_at
38333_at
38334_g_at
38335_at
4968
8077635
AB000410_s_at
A_14_P200082
A_23_P212196
A_23_P344392
A_24_P414183
GE58739
GO:0003677
GO:0003684
GO:0003824
GO:0004519
GO:0005515
GO:0005634
GO:0005654
GO:0005739
GO:0005759
GO:0005829
GO:0006281
GO:0006284
GO:0006285
GO:0006289
GO:0006351
GO:0006355
GO:0006974
GO:0006979
GO:0008017
GO:0008092
GO:0008152
GO:0008534
GO:0009314
GO:0009410
GO:0009416
GO:0012501
GO:0016363
GO:0016607
GO:0016787
GO:0016798
GO:0016829
GO:0019104
GO:0032355
GO:0032357
GO:0032991
GO:0034039
GO:0043066
GO:0043226
GO:0045007
GO:0045008
GO:0045471
GO:0051593
GO:0051716
GO:0055086
GO:0071276
GO:0071704
GO:0140078
GO:0140097
GO:1901135
GO:1901291
HMNXSV003027366
HMNXSV003040435
HMNXSV003055999
ILMN_1706652
ILMN_2352609
PH_hs_0024314
TC03000042.hg
TC03002210.hg
g8670531_3p_a_at
g8670533_3p_a_at
Participates
as a member of
Other forms of this molecule
OGG1 A53T [nucleoplasm]
OGG1 A288V [nucleoplasm]
OGG1 S326C [nucleoplasm]
OGG1 K249Q [nucleoplasm]
OGG1 D268A [nucleoplasm]
SOH-C326-OGG1 S326C [nucleoplasm]
OGG1 R154H [nucleoplasm]
OGG1 R46Q [nucleoplasm]
OGG1 R229Q [nucleoplasm]
OGG1 R131Q [nucleoplasm]
OGG1 P266fs*139 [nucleoplasm]
OGG1 R46L [nucleoplasm]
OGG1 R131G [nucleoplasm]
OGG1 [nucleoplasm]
Modified Residues
Name
L-aspartic acid 268 replaced with L-asparagine
Coordinate
268
PsiMod
L-aspartic acid removal [MOD:01634]
A protein modification that effectively removes or replaces an L-aspartic acid.
L-asparagine residue [MOD:00012]
A protein modification that effectively converts a source amino acid residue to an L-asparagine.
Disease
Name Identifier Synonyms
genetic disease DOID:630
Cross References
RefSeq
Guide to Pharmacology - Targets
ClinGen
OpenTargets
IntEnz
GeneCards
HPA
Ensembl
PRO
Pharos - Targets
PDB
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