Reactome | NEIL1,NEIL2 displace OGG1 from AP-dsDNA

NEIL1,NEIL2 displace OGG1 from AP-dsDNA

Stable Identifier

R-HSA-5649701

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Summation

Although NEIL1 and NEIL2 have a weak 8-oxoguanine glycosylase activity, NEIL1 (and probably NEIL2) enhance OGG1 efficiency against 8-oxogunanine by displacing OGG1 from created AP (apurinic/apyrimidinic) sites and thereby increasing OGG1 turnover (Wiederhold et al. 2004, Hazra et al. 2002a and 2002b).

Literature References

PubMed ID	Title	Journal	Year
12097317	Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions Hazra, TK, Kow, YW, Hatahet, Z, Imhoff, B, Boldogh, I, Mokkapati, SK, Mitra, S, Izumi, T	J. Biol. Chem.	2002
11904416	Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA Hazra, TK, Izumi, T, Boldogh, I, Imhoff, B, Kow, YW, Jaruga, P, Dizdaroglu, M, Mitra, S	Proc. Natl. Acad. Sci. U.S.A.	2002
15260972	AP endonuclease-independent DNA base excision repair in human cells Wiederhold, L, Leppard, JB, Kedar, P, Karimi-Busheri, F, Rasouli-Nia, A, Weinfeld, M, Tomkinson, AE, Izumi, T, Prasad, R, Wilson, SH, Mitra, S, Hazra, TK	Mol. Cell	2004