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OGG1 D268A [nucleoplasm]
Stable Identifier
R-HSA-9663727
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
OGG1 Asp268Ala
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of DNA repair (Homo sapiens)
Diseases of Base Excision Repair (Homo sapiens)
Defective Base Excision Repair Associated with OGG1 (Homo sapiens)
Defective OGG1 Substrate Processing (Homo sapiens)
Defective OGG1 mutants do not excise 8-oxoguanine (Homo sapiens)
OGG1 mutants:(8oxoG:Cyt)-dsDNA [nucleoplasm] (Homo sapiens)
OGG1 mutants (8oxoG hydrolysis) [nucleoplasm] (Homo sapiens)
OGG1 D268A [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
11902834
Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase
Pearl, LH
,
Seeberg, E
,
Bjørås, M
,
Luna, L
,
Barrett, TE
J. Mol. Biol.
2002
External Reference Information
External Reference
UniProt:O15527 OGG1
Gene Names
OGG1, MMH, MUTM, OGH1
Chain
chain:1-345
Reference Genes
COSMIC (genes):OGG1 OGG1
dbSNP Gene:4968 OGG1
ENSEMBL:ENSG00000114026 OGG1
Participates
as a member of
OGG1 mutants (8oxoG hydrolysis) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
OGG1 A53T [nucleoplasm]
OGG1 A288V [nucleoplasm]
OGG1 S326C [nucleoplasm]
OGG1 K249Q [nucleoplasm]
SOH-C326-OGG1 S326C [nucleoplasm]
OGG1 D268N [nucleoplasm]
OGG1 R154H [nucleoplasm]
OGG1 R46Q [nucleoplasm]
OGG1 R229Q [nucleoplasm]
OGG1 R131Q [nucleoplasm]
OGG1 P266fs*139 [nucleoplasm]
OGG1 R46L [nucleoplasm]
OGG1 R131G [nucleoplasm]
OGG1 [nucleoplasm]
Modified Residues
Name
L-aspartic acid 268 replaced with L-alanine
Coordinate
268
PsiMod
L-alanine residue [MOD:00010]
A protein modification that effectively converts a source amino acid residue to an L-alanine.
L-aspartic acid removal [MOD:01634]
A protein modification that effectively removes or replaces an L-aspartic acid.
Disease
Name
Identifier
Synonyms
genetic disease
DOID:630
Cross References
ClinGen
CA351714664
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