Besides recognizing 8-oxoguanine in the oxidation-damaged DNA, OGG1 also recognizes guanine derivative FapyG (Hu et al. 2005). FapyG stands for 2,6-diamino-4-hydroxy-5-formamidopyrimidine, a ring-opened lesion that forms when hydroxyl radicals attack guanine, followed by one-electron reduction of the hydroxyl adduct radicals (Evans et al. 2004).
de Souza-Pinto, NC,