OGG1 glycosylase mediated recognition and binding of a formamidopyrimidine (FapyG)

Stable Identifier
R-HSA-110236
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Besides recognizing 8-oxoguanine in the oxidation-damaged DNA, OGG1 also recognizes guanine derivative FapyG (Hu et al. 2005). FapyG stands for 2,6-diamino-4-hydroxy-5-formamidopyrimidine, a ring-opened lesion that forms when hydroxyl radicals attack guanine, followed by one-electron reduction of the hydroxyl adduct radicals (Evans et al. 2004).

Literature References
PubMed ID Title Journal Year
15341901 Oxidative DNA damage and disease: induction, repair and significance

Evans, MD, Dizdaroglu, M, Cooke, MS

Mutat. Res. 2004
16221681 Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes

Hu, J, de Souza-Pinto, NC, Haraguchi, K, Hogue, BA, Jaruga, P, Greenberg, MM, Dizdaroglu, M, Bohr, VA

J. Biol. Chem. 2005
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