Besides recognizing 8-oxoguanine in the oxidation-damaged DNA, OGG1 also recognizes guanine derivative FapyG (Hu et al. 2005). FapyG stands for 2,6-diamino-4-hydroxy-5-formamidopyrimidine, a ring-opened lesion that forms when hydroxyl radicals attack guanine, followed by one-electron reduction of the hydroxyl adduct radicals (Evans et al. 2004).
Evans, MD, Dizdaroglu, M, Cooke, MS
Hu, J, de Souza-Pinto, NC, Haraguchi, K, Hogue, BA, Jaruga, P, Greenberg, MM, Dizdaroglu, M, Bohr, VA
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