OGG1 S326C [nucleoplasm]

Stable Identifier
R-HSA-9658769
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
OGG1 Ser326Cys
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
15073047 Differential ability of polymorphic OGG1 proteins to suppress mutagenesis induced by 8-hydroxyguanine in human cell in vivo

Yamane, A, Kohno, T, Ito, K, Sunaga, N, Aoki, K, Yoshimura, K, Murakami, H, Nojima, Y, Yokota, J

Carcinogenesis 2004
26089588 OGG1 Mutations and Risk of Female Breast Cancer: Meta-Analysis and Experimental Data

Ali, K, Mahjabeen, I, Sabir, M, Mehmood, H, Kayani, MA

Dis. Markers 2015
11459633 DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326

Janssen, K, Schlink, K, Götte, W, Hippler, B, Kaina, B, Oesch, F

Mutat. Res. 2001
21376741 8-Oxoguanine incision activity is impaired in lung tissues of NSCLC patients with the polymorphism of OGG1 and XRCC1 genes

Janik, J, Swoboda, M, Janowska, B, Cieśla, JM, Gackowski, D, Kowalewski, J, Olinski, R, Tudek, B, Speina, E

Mutat. Res. 2011
24632493 hOGG1-Cys326 variant cells are hypersensitive to DNA repair inhibition by nitric oxide

Moritz, E, Pauly, K, Bravard, A, Hall, J, Radicella, JP, Epe, B

Carcinogenesis 2014
22451681 Repair of oxidative DNA damage is delayed in the Ser326Cys polymorphic variant of the base excision repair protein OGG1

Kershaw, RM, Hodges, NJ

Mutagenesis 2012
10497264 Excision of oxidatively damaged DNA bases by the human alpha-hOgg1 protein and the polymorphic alpha-hOgg1(Ser326Cys) protein which is frequently found in human populations

Dherin, C, Radicella, JP, Dizdaroglu, M, Boiteux, S

Nucleic Acids Res. 1999
External Reference Information
External Reference
UniProt:O15527 OGG1
Gene Names
OGG1, MMH, MUTM, OGH1
Chain
chain:1-345
Reference Genes
BioGPS Gene:4968 OGG1
COSMIC (genes):OGG1 OGG1
CTD Gene:4968 OGG1
dbSNP Gene:4968 OGG1
ENSEMBL:ENSG00000114026 OGG1
HGNC:8125 OGG1
KEGG Gene (Homo sapiens):4968 OGG1
Monarch:4968 OGG1
NCBI Gene:4968 OGG1
OMIM:601982 OGG1
UCSC:O15527 OGG1
Reference Transcript
Other Identifiers
0002060524
0004810403
11727607_a_at
11727608_x_at
11727696_x_at
11740749_a_at
16937329
1EBM
1FN7
1HU0
1KO9
1LWV
1LWW
1LWY
1M3H
1M3Q
1N39
1N3A
1N3C
1YQK
1YQL
1YQM
1YQR
205301_s_at
205760_s_at
2609907
2609908
2609909
2609910
2609913
2609914
2609916
2609917
2609918
2609920
2609921
2609922
2609923
2609924
2609925
2609926
2609927
2609929
2609930
2609931
27514
2I5W
2NOB
2NOE
2NOF
2NOH
2NOI
2NOL
2NOZ
2XHI
34146_at
34147_g_at
38333_at
38334_g_at
38335_at
3IH7
3KTU
47301
4968
5AN4
8077635
A_14_P200082
A_23_P212196
A_23_P344392
A_24_P414183
AAB61340
AAB68614
AAB68615
AAB81132
AAB84013
AAD41680
AAD41681
AAD41682
AAH00657
AAM74236
AB000410
AB000410_s_at
AB019528
AB019529
AB019530
AB019531
AB019532
AC022382
ADQ20117
ADQ20118
ADQ20119
ADQ20120
ADQ20121
ADQ20122
ADQ20123
ADQ20124
ADQ20125
ADQ20126
ADQ20127
ADQ20128
ADQ20129
ADQ20130
ADQ20131
ADQ20132
ADQ20133
ADQ20134
ADQ20135
ADQ20136
ADQ20137
ADQ20138
ADQ20139
ADQ20140
ADQ20141
ADQ20142
ADQ20143
ADQ20144
ADQ20145
ADQ20146
ADQ20147
ADQ20148
ADQ20149
ADQ20150
ADQ20151
ADQ20152
ADQ20153
ADQ20154
ADQ20155
ADQ20156
ADQ20157
ADQ20158
ADQ20159
ADQ20160
ADQ20161
ADQ20162
ADQ20163
ADQ20166
ADQ20167
ADQ20168
ADQ20169
ADQ20170
ADQ20171
ADQ20172
ADQ20173
ADQ20174
ADQ20175
ADQ20176
ADQ20177
ADQ20178
ADQ20179
ADQ20180
ADQ20181
ADQ20182
ADQ20183
ADQ20184
ADQ20185
ADQ20186
ADQ20187
ADQ20188
ADQ20189
ADQ20190
ADQ20191
ADQ20192
ADQ20193
ADQ20194
ADQ20195
ADQ20196
ADQ20197
ADQ20198
ADQ20199
ADQ20200
ADQ20201
ADQ20202
ADQ20203
ADQ20204
ADQ20205
ADQ20206
ADQ20207
ADQ20208
ADQ20209
ADQ20210
ADQ20211
ADQ20212
ADQ20215
ADQ20216
ADQ20217
ADQ20218
ADQ20219
ADQ20220
ADQ20221
ADQ20222
ADQ20223
ADQ20224
ADQ20225
ADQ20226
ADQ20227
ADQ20228
ADQ20229
ADQ20230
ADQ20231
ADQ20232
ADQ20233
ADQ20234
ADQ20235
ADQ20236
ADQ20237
ADQ20238
ADQ20239
ADQ20240
ADQ20241
ADQ20242
ADQ20243
ADQ20244
ADQ20245
ADQ20246
ADQ20247
ADQ20250
ADQ20251
ADQ20252
ADQ20253
ADQ20254
ADQ20257
ADQ20258
ADQ20259
ADQ20260
ADQ20261
ADQ20262
ADQ20263
ADQ20264
ADQ20265
ADQ20266
ADQ20267
ADQ20268
ADQ20269
ADQ20270
ADQ20271
ADQ20272
ADQ20273
ADQ20274
ADQ20275
ADQ20276
ADQ20277
ADQ20278
ADQ20279
ADQ20280
ADQ20281
ADQ20282
ADQ20283
ADQ20284
ADQ20285
ADQ20286
ADQ20287
ADQ20288
ADQ20289
ADQ20290
ADQ20291
ADQ20292
ADQ20293
ADQ20294
ADQ20295
ADQ20296
ADQ20297
ADQ20298
ADQ20299
ADQ20300
ADQ20301
ADQ20302
ADQ20303
ADQ20304
ADQ20305
ADQ20306
ADQ20307
ADQ20308
ADQ20309
ADQ20310
ADQ20311
ADQ20312
ADQ20313
ADQ20314
ADQ20315
ADQ20316
ADQ20317
ADQ20318
ADQ20319
ADQ20320
ADQ20321
ADQ20322
ADQ20323
ADQ20324
ADQ20325
ADQ20326
ADQ20327
ADQ20328
ADQ20329
ADQ20330
ADQ20331
ADQ20332
ADQ20333
ADQ20334
ADQ20335
ADQ20336
ADQ20337
ADQ20338
ADQ20339
ADQ20340
ADQ20341
ADQ20342
ADQ20343
ADQ20344
ADQ20345
ADQ20346
ADQ20347
ADQ20348
ADQ20349
ADQ20350
ADQ20351
ADQ20352
ADQ20353
ADQ20354
ADQ20355
ADQ20356
ADQ20357
ADQ20358
ADQ20359
ADQ20360
ADQ20361
ADQ20362
ADQ20363
ADQ20364
ADQ20365
ADQ20366
ADQ20367
ADQ20368
ADQ20369
ADQ20370
ADQ20371
ADQ20372
ADQ20373
ADQ20374
ADQ20375
ADQ20376
ADQ20377
ADQ20378
ADQ20379
ADQ20380
ADQ20381
ADQ20382
ADQ20383
ADQ20384
ADQ20385
ADQ20386
ADQ20387
ADQ20388
ADQ20389
ADQ20390
ADQ20391
ADQ20392
ADQ20393
ADQ20394
ADQ20395
ADQ20396
AF003595
AF026691
AF088282
AF521807
AJ131341
AK289858
BAA19103
BAA76635
BAA76636
BAA76637
BAA76638
BAA76639
BAF82547
BC000657
CAA10351
CAA72414
CAA72536
CAA73726
CAB047301
CCDS2576
CCDS2577
CCDS2578
CCDS2579
CCDS2580
CCDS2581
CCDS43046
CCDS46742
CH471055
E5KPM5
E5KPM6
E5KPM7
E5KPM8
E5KPM9
E5KPN0
E5KPN1
EAW63978
EAW63981
EAW63982
EAW63983
EAW63985
EAW63987
EAW63988
ENSG00000114026
ENSP00000303132
ENSP00000305527
ENSP00000305584
ENSP00000306561
ENSP00000342851
ENSP00000345520
ENSP00000373337
ENSP00000403598
ENST00000302003
ENST00000302003.11
ENST00000302008
ENST00000302008.12
ENST00000302036
ENST00000302036.11
ENST00000339511
ENST00000339511.9
ENST00000344629
ENST00000344629.11
ENST00000349503
ENST00000349503.9
ENST00000383826
ENST00000383826.9
ENST00000449570
ENST00000449570.6
EntrezGene:4968
EntrezGene:OGG1
F8WCZ9
g8670531_3p_a_at
g8670533_3p_a_at
GE58739
GO:0002526
GO:0003674
GO:0003677
GO:0003684
GO:0003824
GO:0004518
GO:0004519
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0006259
GO:0006281
GO:0006284
GO:0006285
GO:0006289
GO:0006355
GO:0006950
GO:0006974
GO:0006979
GO:0007568
GO:0008017
GO:0008092
GO:0008150
GO:0008152
GO:0008219
GO:0008534
GO:0009056
GO:0009058
GO:0009314
GO:0009416
GO:0016363
GO:0016607
GO:0016787
GO:0016798
GO:0016829
GO:0019104
GO:0032355
GO:0032357
GO:0032991
GO:0033683
GO:0034039
GO:0034641
GO:0034655
GO:0042493
GO:0043066
GO:0043226
GO:0044281
GO:0045007
GO:0045008
GO:0045471
GO:0051593
GO:0071276
GO:0140078
GO:1901291
HGNC:8125
HPA027514
HQ205506
HQ205507
HQ205508
HQ205509
HQ205510
HQ205511
HQ205512
HQ205513
HQ205514
HQ205515
HQ205516
HQ205517
HQ205518
HQ205519
HQ205520
HQ205521
HQ205522
HQ205523
HQ205524
HQ205525
HQ205526
HQ205527
HQ205528
HQ205529
HQ205530
HQ205531
HQ205532
HQ205533
HQ205534
HQ205535
HQ205536
HQ205537
HQ205538
HQ205539
HQ205540
HQ205541
HQ205542
HQ205543
HQ205544
HQ205545
ILMN_1706652
ILMN_1808340
ILMN_2352609
IPR003265
IPR004577
IPR011257
IPR012904
IPR023170
MIM:144700
MIM:601982
NM_001354648
NM_001354649
NM_001354650
NM_001354651
NM_001354652
NM_002542
NM_016819
NM_016820
NM_016821
NM_016826
NM_016827
NM_016828
NM_016829
NP_001341577
NP_001341578
NP_001341579
NP_001341580
NP_001341581
NP_002533
NP_058212
NP_058213
NP_058214
NP_058434
NP_058436
NP_058437
NP_058438
NR_148930
NR_148932
OGG1
OGG1-201
OGG1-202
OGG1-203
OGG1-204
OGG1-205
OGG1-206
OGG1-209
OGG1-217
PF00730
PF07934
PH_hs_0024314
SM00478
TC03000042.hg
TC03002210.hg
U88527
U88620
U96710
UPI000002B019
UPI000002B01A
UPI000002B01B
UPI000002B01C
UPI000002B01D
UPI000002B01F
UPI0000130C46
UPI000013E77E
XM_011533760
XM_017006493
XM_017006494
XM_017006495
XM_017006496
XM_017006497
XM_017006499
XP_011532062
XP_016861982
XP_016861983
XP_016861984
XP_016861985
XP_016861986
XP_016861988
XR_001740156
Y11731
Y11838
Y13277
Participant Of
input
Other forms of this molecule
OGG1 A53T [nucleoplasm]
OGG1 A288V [nucleoplasm]
OGG1 K249Q [nucleoplasm]
OGG1 D268A [nucleoplasm]
SOH-C326-OGG1 S326C [nucleoplasm]
OGG1 D268N [nucleoplasm]
OGG1 R154H [nucleoplasm]
OGG1 R46Q [nucleoplasm]
OGG1 R229Q [nucleoplasm]
OGG1 R131Q [nucleoplasm]
OGG1 P266fs139* [nucleoplasm]
OGG1 R46L [nucleoplasm]
OGG1 R131G [nucleoplasm]
OGG1 [nucleoplasm]
Modified Residues
Name
L-serine 326 replaced with L-cysteine
Coordinate
326
PsiMod
L-cysteine residue [MOD:00014]
A protein modification that effectively converts a source amino acid residue to an L-cysteine.
L-serine removal [MOD:01646]
A protein modification that effectively removes or replaces an L-serine.
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
OpenTargets
IntEnz
GeneCards
PRO
PDB