Reactome | OGG1 S326C [nucleoplasm]

OGG1 S326C [nucleoplasm]

Stable Identifier

R-HSA-9658769

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

OGG1 Ser326Cys

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of DNA repair (Homo sapiens)
  - Diseases of Base Excision Repair (Homo sapiens)
    - Defective Base Excision Repair Associated with OGG1 (Homo sapiens)
      - Defective OGG1 Substrate Processing (Homo sapiens)
        
        OGG1 S326C is oxidized (Homo sapiens)
        
        OGG1 S326C [nucleoplasm] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
26089588	OGG1 Mutations and Risk of Female Breast Cancer: Meta-Analysis and Experimental Data Ali, K, Kayani, MA, Mehmood, H, Mahjabeen, I, Sabir, M	Dis. Markers	2015
15073047	Differential ability of polymorphic OGG1 proteins to suppress mutagenesis induced by 8-hydroxyguanine in human cell in vivo Aoki, K, Ito, K, Nojima, Y, Sunaga, N, Yokota, J, Kohno, T, Murakami, H, Yoshimura, K, Yamane, A	Carcinogenesis	2004
11459633	DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326 Schlink, K, Götte, W, Hippler, B, Janssen, K, Oesch, F, Kaina, B	Mutat. Res.	2001
21376741	8-Oxoguanine incision activity is impaired in lung tissues of NSCLC patients with the polymorphism of OGG1 and XRCC1 genes Tudek, B, Cieśla, JM, Speina, E, Janik, J, Gackowski, D, Swoboda, M, Janowska, B, Olinski, R, Kowalewski, J	Mutat. Res.	2011
24632493	hOGG1-Cys326 variant cells are hypersensitive to DNA repair inhibition by nitric oxide Radicella, JP, Hall, J, Pauly, K, Epe, B, Bravard, A, Moritz, E	Carcinogenesis	2014
22451681	Repair of oxidative DNA damage is delayed in the Ser326Cys polymorphic variant of the base excision repair protein OGG1 Hodges, NJ, Kershaw, RM	Mutagenesis	2012
10497264	Excision of oxidatively damaged DNA bases by the human alpha-hOgg1 protein and the polymorphic alpha-hOgg1(Ser326Cys) protein which is frequently found in human populations Radicella, JP, Boiteux, S, Dizdaroglu, M, Dherin, C	Nucleic Acids Res.	1999

External Reference Information

External Reference

UniProt:O15527 OGG1

Gene Names

OGG1, MMH, MUTM, OGH1

Chain

chain:1-345

Reference Genes

BioGPS Gene:4968 OGG1

COSMIC (genes):OGG1 OGG1

CTD Gene:4968 OGG1

dbSNP Gene:4968 OGG1

ENSEMBL:ENSG00000114026 OGG1

ENSEMBL:ENSG00000114026.22 OGG1

HGNC:8125 OGG1

KEGG Gene (Homo sapiens):4968 OGG1

Monarch:4968 OGG1

NCBI Gene:4968 OGG1

OMIM:601982 OGG1

UCSC:O15527 OGG1

Reference Transcript

Other Identifiers

11727607_a_at

11727608_x_at

11727696_x_at

11740749_a_at

16937329

205301_PM_s_at

205301_s_at

205760_PM_s_at

205760_s_at

2609907

2609908

2609909

2609910

2609913

2609914

2609916

2609917

2609918

2609920

2609921

2609922

2609923

2609924

2609925

2609926

2609927

2609929

2609930

2609931

34146_at

34147_g_at

38333_at

38334_g_at

38335_at

4968

8077635

AB000410_s_at

A_14_P200082

A_23_P212196

A_23_P344392

A_24_P414183

GE58739

GO:0003677

GO:0003684

GO:0003824

GO:0004519

GO:0005515

GO:0005634

GO:0005654

GO:0005739

GO:0005759

GO:0005829

GO:0006281

GO:0006284

GO:0006285

GO:0006289

GO:0006351

GO:0006355

GO:0006974

GO:0006979

GO:0008017

GO:0008092

GO:0008152

GO:0008534

GO:0009314

GO:0009410

GO:0009416

GO:0012501

GO:0016363

GO:0016607

GO:0016787

GO:0016798

GO:0016829

GO:0019104

GO:0032355

GO:0032357

GO:0032991

GO:0033554

GO:0034039

GO:0043066

GO:0043226

GO:0045007

GO:0045008

GO:0045471

GO:0051593

GO:0055086

GO:0071276

GO:0140078

GO:0140097

GO:1901135

GO:1901291

HMNXSV003027366

HMNXSV003040435

HMNXSV003055999

ILMN_1706652

ILMN_2352609

PH_hs_0024314

TC03000042.hg

TC03002210.hg

g8670531_3p_a_at

g8670533_3p_a_at

Participates

as an input of

OGG1 S326C is oxidized (Homo sapiens)

Other forms of this molecule

OGG1 A53T [nucleoplasm]

OGG1 A288V [nucleoplasm]

OGG1 K249Q [nucleoplasm]

OGG1 D268A [nucleoplasm]

SOH-C326-OGG1 S326C [nucleoplasm]

OGG1 D268N [nucleoplasm]

OGG1 R154H [nucleoplasm]

OGG1 R46Q [nucleoplasm]

OGG1 R229Q [nucleoplasm]

OGG1 R131Q [nucleoplasm]

OGG1 P266fs*139 [nucleoplasm]

OGG1 R46L [nucleoplasm]

OGG1 R131G [nucleoplasm]

OGG1 [nucleoplasm]

Modified Residues

Name

L-serine 326 replaced with L-cysteine

Coordinate

326

PsiMod

L-serine removal [MOD:01646]

A protein modification that effectively removes or replaces an L-serine.

L-cysteine residue [MOD:00014]

A protein modification that effectively converts a source amino acid residue to an L-cysteine.

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Cross References

RefSeq

NP_058212.1, NP_058214.1, NP_058438.1, NP_058213.1, NP_058437.1, NP_058434.1, NP_058436.1, NP_002533.1

Guide to Pharmacology - Targets

3060

OpenTargets

ENSG00000114026

IntEnz

4.2.99.18

HPA

ENSG00000114026-OGG1

GeneCards

O15527

Ensembl

ENSP00000403598, ENST00000339511, ENST00000344629, ENSP00000345520, ENSG00000114026, ENSP00000306561, ENSP00000305584, ENST00000302036, ENST00000383826, ENST00000302008, ENST00000449570, ENST00000302003, ENSP00000373337, ENSP00000305527, ENSP00000342851

PRO

O15527

Pharos - Targets

O15527

PDB

1N3A, 2XHI, 2NOE, 3IH7, 1LWY, 2NOL, 1M3Q, 7AYY, 1YQM, 2NOI, 5AN4, 2NOB, 1EBM, 6W0M, 1LWW, 1KO9, 1N39, 1YQL, 2NOH, 1M3H, 1FN7, 3KTU, 1LWV, 6W0R, 2NOZ, 1YQK, 6RLW, 1N3C, 1HU0, 2NOF, 2I5W, 6W13, 1YQR