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SOH-C326-OGG1 S326C [nucleoplasm]
Stable Identifier
R-HSA-9658815
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of DNA repair (Homo sapiens)
Diseases of Base Excision Repair (Homo sapiens)
Defective Base Excision Repair Associated with OGG1 (Homo sapiens)
Defective OGG1 Substrate Processing (Homo sapiens)
Defective OGG1 mutants do not excise 8-oxoguanine (Homo sapiens)
OGG1 mutants:(8oxoG:Cyt)-dsDNA [nucleoplasm] (Homo sapiens)
OGG1 mutants (8oxoG hydrolysis) [nucleoplasm] (Homo sapiens)
SOH-C326-OGG1 S326C [nucleoplasm] (Homo sapiens)
Defective OGG1 mutants do not excise FapyG (Homo sapiens)
OGG1 mutants:FapyG-dsDNA [nucleoplasm] (Homo sapiens)
OGG1 mutants (FapyG hydrolysis) [nucleoplasm] (Homo sapiens)
SOH-C326-OGG1 S326C [nucleoplasm] (Homo sapiens)
OGG1 S326C is oxidized (Homo sapiens)
SOH-C326-OGG1 S326C [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
24632493
hOGG1-Cys326 variant cells are hypersensitive to DNA repair inhibition by nitric oxide
Radicella, JP
,
Hall, J
,
Pauly, K
,
Epe, B
,
Bravard, A
,
Moritz, E
Carcinogenesis
2014
External Reference Information
External Reference
UniProt:O15527 OGG1
Gene Names
OGG1, MMH, MUTM, OGH1
Chain
chain:1-345
Reference Genes
BioGPS Gene:4968 OGG1
COSMIC (genes):OGG1 OGG1
CTD Gene:4968 OGG1
dbSNP Gene:4968 OGG1
ENSEMBL:ENSG00000114026 OGG1
HGNC:8125 OGG1
KEGG:hsa:4968 OGG1
Monarch:4968 OGG1
NCBI Gene:4968 OGG1
OMIM:601982 OGG1
UCSC:O15527 OGG1
Reference Transcript
RefSeq:NM_016827.3 OGG1
RefSeq:NM_016829.3 OGG1
RefSeq:NM_016821.3 OGG1
RefSeq:NM_016819.4 OGG1
RefSeq:NM_016828.3 OGG1
RefSeq:NM_016826.3 OGG1
RefSeq:NM_002542.6 OGG1
RefSeq:NM_016820.4 OGG1
Participates
as a member of
OGG1 mutants (FapyG hydrolysis) [nucleoplasm] (Homo sapiens)
OGG1 mutants (8oxoG hydrolysis) [nucleoplasm] (Homo sapiens)
as an output of
OGG1 S326C is oxidized (Homo sapiens)
Other forms of this molecule
OGG1 [nucleoplasm]
OGG1 R131G [nucleoplasm]
OGG1 R46L [nucleoplasm]
OGG1 P266fs*139 [nucleoplasm]
OGG1 R131Q [nucleoplasm]
OGG1 R229Q [nucleoplasm]
OGG1 R46Q [nucleoplasm]
OGG1 R154H [nucleoplasm]
OGG1 D268N [nucleoplasm]
OGG1 D268A [nucleoplasm]
OGG1 K249Q [nucleoplasm]
OGG1 S326C [nucleoplasm]
OGG1 A288V [nucleoplasm]
OGG1 A53T [nucleoplasm]
Modified Residues
Name
L-serine 326 replaced with L-cysteine
Coordinate
326
PsiMod
L-serine removal [MOD:01646]
A protein modification that effectively removes or replaces an L-serine.
L-cysteine residue [MOD:00014]
A protein modification that effectively converts a source amino acid residue to an L-cysteine.
Name
L-cysteine sulfenic acid at 326
Coordinate
326
PsiMod Name
L-cysteine sulfenic acid
PsiMod Definition
A protein modification that effectively monooxygenates an L-cysteine residue to L-cysteine sulfenic acid.
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
NP_058212.1
,
NP_058438.1
,
NP_002533.1
,
NP_058213.1
,
NP_058214.1
,
NP_058434.1
,
NP_058436.1
,
NP_058437.1
Guide to Pharmacology - Targets
3060
OpenTargets
ENSG00000114026
ENSEMBL
ENSP00000305527
,
ENSP00000345520
,
ENST00000344629
,
ENST00000302008
,
ENST00000449570
,
ENST00000302036
,
ENST00000302003
,
ENSP00000373337
,
ENSP00000344899
,
ENSP00000306561
,
ENST00000383826
,
ENSG00000114026
,
ENSP00000403598
,
ENST00000339511
,
ENSP00000305584
,
ENST00000352937
,
ENSP00000342851
IntEnz
4.2.99.18
GeneCards
OGG1
HPA
ENSG00000114026-OGG1
PRO
O15527
Pharos - Targets
O15527
PDB
7AYY
,
8VWV
,
2NOL
,
6W0M
,
2NOZ
,
1KO9
,
8VX6
,
2NOB
,
6W0R
,
1M3Q
,
8VWT
,
6W13
,
1EBM
,
5AN4
,
2I5W
,
1LWW
,
1FN7
,
1LWV
,
1LWY
,
9EOZ
,
1YQL
,
1N39
,
1YQM
,
2NOF
,
2NOI
,
1HU0
,
1YQK
,
1YQR
,
2XHI
,
1M3H
,
6RLW
,
1N3C
,
2NOE
,
8VX4
,
2NOH
,
1N3A
,
3IH7
,
3KTU
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