OGG1 R229Q [nucleoplasm]

Stable Identifier
R-HSA-9657082
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
OGG1 Arg229Gln
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OGG1 R229Q [nucleoplasm] icon
OGG1 R229Q [nucleoplasm] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
11002420 Leukemic cell line, KG-1 has a functional loss of hOGG1 enzyme due to a point mutation and 8-hydroxydeoxyguanosine can kill KG-1

Hyun, JW, Choi, JY, Zeng, HH, Lee, YS, Kim, HS, Yoon, SH, Chung, MH

Oncogene 2000
17651912 A novel R229Q OGG1 polymorphism results in a thermolabile enzyme that sensitizes KG-1 leukemia cells to DNA damaging agents

Hill, JW, Evans, MK

Cancer Detect. Prev. 2007
11827746 Radiation sensitivity depends on OGG1 activity status in human leukemia cell lines

Hyun, JW, Cheon, GJ, Kim, HS, Lee, YS, Choi, EY, Yoon, BH, Kim, JS, Chung, MH

Free Radic. Biol. Med. 2002
External Reference Information
External Reference
UniProt:O15527 OGG1
Gene Names
OGG1, MMH, MUTM, OGH1
Chain
chain:1-345
Reference Genes
BioGPS Gene:4968 OGG1
COSMIC (genes):OGG1 OGG1
CTD Gene:4968 OGG1
dbSNP Gene:4968 OGG1
ENSEMBL:ENSG00000114026 OGG1
HGNC:8125 OGG1
KEGG:hsa:4968 OGG1
Monarch:4968 OGG1
NCBI Gene:4968 OGG1
OMIM:601982 OGG1
UCSC:O15527 OGG1
Reference Transcript
Participates
as a member of
Other forms of this molecule
OGG1 [nucleoplasm]
OGG1 R131G [nucleoplasm]
OGG1 R46L [nucleoplasm]
OGG1 P266fs*139 [nucleoplasm]
OGG1 R131Q [nucleoplasm]
OGG1 R46Q [nucleoplasm]
OGG1 R154H [nucleoplasm]
OGG1 D268N [nucleoplasm]
SOH-C326-OGG1 S326C [nucleoplasm]
OGG1 D268A [nucleoplasm]
OGG1 K249Q [nucleoplasm]
OGG1 S326C [nucleoplasm]
OGG1 A288V [nucleoplasm]
OGG1 A53T [nucleoplasm]
Modified Residues
Name
L-arginine 229 replaced with L-glutamine
Coordinate
229
PsiMod
L-arginine removal [MOD:01632]
A protein modification that effectively removes or replaces an L-arginine.
L-glutamine residue [MOD:00016]
A protein modification that effectively converts a source amino acid residue to an L-glutamine.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
acute myeloid leukemia DOID:9119 Leukemia, Myelocytic, acute, acute myeloblastic leukemia, acute myelogenous leukemia, AML - acute Myeloid Leukemia
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
Mondo
GeneCards
HPA
PRO
Pharos - Targets
PDB
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