OGG1 is an N-glycosylase and DNA lyase that recognizes oxidative DNA damage in the form of 8-oxoguanine (8oxoG). 8oxoG forms at a high frequency in the DNA of aerobic organisms. As 8oxoG has a preference for mispairing with adenine, it is one of the underlying causes of G:C -> T:A transversions, the type of mutation frequently found in cancer (Aburatani et al. 1997, Rosenquist et al. 1997, Roldan-Arjona et al. 1997, Radicella et al. 1997, Bjoras et al. 1997, Bruner et al. 2000).
Anselmino, C, Wei, YF, Wang, RP, Augustus, M, Lindahl, T, Carter, KC, Klungland, A, Roldán-Arjona, T
Luna, L, Hoff, E, Bjorâs, M, Johnsen, B, Haug, T, Rognes, T, Seeberg, E
Zharkov, DO, Grollman, AP, Rosenquist, TA
Desmaze, C, Radicella, JP, Boiteux, S, Fox, MS, Dherin, C
Bruner, SD, Verdine, GL, Norman, DP
Yamamoto, K, Takao, M, Yasui, A, Asano, M, Ishida, T, Takashima, R, Kodama, T, Hippo, Y, Aburatani, H, Matsuba, C
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