OGG1 glycosylase mediated recognition and binding of an 8-oxoguanine opposite to a cytosine

Stable Identifier
R-HSA-110235
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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OGG1 glycosylase mediated recognition and binding of an 8-oxoguanine opposite to a cytosine
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OGG1 is an N-glycosylase and DNA lyase that recognizes oxidative DNA damage in the form of 8-oxoguanine (8oxoG). 8oxoG forms at a high frequency in the DNA of aerobic organisms. As 8oxoG has a preference for mispairing with adenine, it is one of the underlying causes of G:C -> T:A transversions, the type of mutation frequently found in cancer (Aburatani et al. 1997, Rosenquist et al. 1997, Roldan-Arjona et al. 1997, Radicella et al. 1997, Bjoras et al. 1997, Bruner et al. 2000).

Literature References
PubMed ID Title Journal Year
9321410 Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites

Bjorâs, M, Luna, L, Johnsen, B, Hoff, E, Haug, T, Rognes, T, Seeberg, E

EMBO J. 1997
9223306 Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase

Roldán-Arjona, T, Wei, YF, Carter, KC, Klungland, A, Anselmino, C, Wang, RP, Augustus, M, Lindahl, T

Proc. Natl. Acad. Sci. U.S.A. 1997
9207108 Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase

Rosenquist, TA, Zharkov, DO, Grollman, AP

Proc. Natl. Acad. Sci. U.S.A. 1997
9223305 Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae

Radicella, JP, Dherin, C, Desmaze, C, Fox, MS, Boiteux, S

Proc. Natl. Acad. Sci. U.S.A. 1997
10706276 Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA

Bruner, SD, Norman, DP, Verdine, GL

Nature 2000
9187114 Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue

Aburatani, H, Hippo, Y, Ishida, T, Takashima, R, Matsuba, C, Kodama, T, Takao, M, Yasui, A, Yamamoto, K, Asano, M

Cancer Res. 1997
Participants
Input
Output
Participant Of
hasEvent
Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)
Vlahopoulos, S  (2019-10-02)
Boldogh, I  (2019-10-08)
Created
Matthews, L  (2004-01-29)