OGG1 is an N-glycosylase and DNA lyase that recognizes oxidative DNA damage in the form of 8-oxoguanine (8oxoG). 8oxoG forms at a high frequency in the DNA of aerobic organisms. As 8oxoG has a preference for mispairing with adenine, it is one of the underlying causes of G:C -> T:A transversions, the type of mutation frequently found in cancer (Aburatani et al. 1997, Rosenquist et al. 1997, Roldan-Arjona et al. 1997, Radicella et al. 1997, Bjoras et al. 1997, Bruner et al. 2000).
Bjorâs, M, Luna, L, Johnsen, B, Hoff, E, Haug, T, Rognes, T, Seeberg, E
Roldán-Arjona, T, Wei, YF, Carter, KC, Klungland, A, Anselmino, C, Wang, RP, Augustus, M, Lindahl, T
Rosenquist, TA, Zharkov, DO, Grollman, AP
Radicella, JP, Dherin, C, Desmaze, C, Fox, MS, Boiteux, S
Bruner, SD, Norman, DP, Verdine, GL
Aburatani, H, Hippo, Y, Ishida, T, Takashima, R, Matsuba, C, Kodama, T, Takao, M, Yasui, A, Yamamoto, K, Asano, M
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