Reactome | MCOLN1 [endosome membrane]

MCOLN1 [endosome membrane]

Stable Identifier

R-HSA-917803

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

Mucolipin-1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9GZU1 MCOLN1

Gene Names

MCOLN1, ML4, TRPML1, MSTP080

Chain

chain:1-580

Reference Genes

BioGPS Gene:57192 MCOLN1

COSMIC (genes):MCOLN1 MCOLN1

CTD Gene:57192 MCOLN1

dbSNP Gene:57192 MCOLN1

ENSEMBL:ENSG00000090674 MCOLN1

HGNC:13356 MCOLN1

KEGG:hsa:57192 MCOLN1

Monarch:57192 MCOLN1

NCBI Entrez Gene:57192 MCOLN1

OMIM:605248 MCOLN1

UCSC:Q9GZU1 MCOLN1

Reference Transcript

RefSeq:NM_020533.3 MCOLN1

Other Identifiers

11718554_a_at

11748969_a_at

16857612

219952_PM_s_at

219952_s_at

3818861

3818862

3818864

3818865

3818866

3818867

3818868

3818869

3818870

3818871

3818872

3818873

3818874

3818875

3818876

3818877

3818878

3818879

3818880

3818881

3818882

3818885

3818886

3818887

3818888

3818889

3818890

3818892

3818893

3818894

3818896

3818898

3818899

3818900

3818901

3818902

3818903

57192

63374_at

8025183

A_14_P112467

A_14_P125418

A_14_P135632

A_23_P27571

GE80875

GO:0001891

GO:0002250

GO:0002376

GO:0005253

GO:0005261

GO:0005262

GO:0005267

GO:0005272

GO:0005381

GO:0005515

GO:0005654

GO:0005764

GO:0005765

GO:0005768

GO:0005770

GO:0005794

GO:0005886

GO:0006811

GO:0006812

GO:0006816

GO:0007040

GO:0008289

GO:0010008

GO:0016020

GO:0019722

GO:0030659

GO:0030670

GO:0031410

GO:0031902

GO:0033572

GO:0034220

GO:0034755

GO:0035725

GO:0042802

GO:0042995

GO:0043235

GO:0045824

GO:0051209

GO:0051289

GO:0055085

GO:0065003

GO:0070588

GO:0071277

GO:0071467

GO:0071805

GO:0072345

GO:0090382

GO:0097352

GO:0097682

GO:0098655

GO:0098656

GO:0099604

GO:0140367

GO:1900181

GO:1900182

GO:1901660

GO:1905673

HMNXSV003054758

ILMN_1764383

TC19000128.hg

g10092596_3p_s_at

Other forms of this molecule

MCOLN1 [plasma membrane]

Inferred To

cup-5 [endosome membrane] (Caenorhabditis elegans)

Mcoln1 [endosome membrane] (Mus musculus)

Mcoln1 [endosome membrane] (Rattus norvegicus)

Trpml [endosome membrane] (Drosophila melanogaster)

mcoln1b [endosome membrane] (Danio rerio)

MCOLN1 [endosome membrane] (Bos taurus)

MCOLN1 [endosome membrane] (Canis familiaris)

MCOLN1 [endosome membrane] (Dictyostelium discoideum)

MCOLN1 [endosome membrane] (Gallus gallus)

MCOLN1 [endosome membrane] (Sus scrofa)

mcoln1 [endosome membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_065394.1

Guide to Pharmacology - Targets

501

ENSEMBL

ENSP00000264079, ENST00000264079, ENSG00000090674

OpenTargets

ENSG00000090674

GeneCards

MCOLN1

HPA

ENSG00000090674-MCOLN1

PRO

Q9GZU1

Pharos - Targets

Q9GZU1

GlyGen

Q9GZU1

Orphanet

MCOLN1

PDB

6E7Y, 5WJ9, 5TJC, 6E7Z, 6E7P, 5TJB, 5TJA, 7MGL, 5WJ5

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9GZU1 MCOLN1	2	MCOLN1 [plasma membrane] (R-HSA-3211764) MCOLN1 [endosome membrane] (R-HSA-917803)	0.606	3
UniProt:Q96IW7 SEC22A	3	SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111)	0.556	3
UniProt:Q92624 APBP2			0.556	3
UniProt:Q8IZK6 MCOLN2	1	MCOLN2 [plasma membrane] (R-HSA-3211766)	0.527	2
UniProt:Q8TDD5 MCOLN3	1	MCOLN3 [plasma membrane] (R-HSA-3211773)	0.527	3
UniProt:Q8N6G5 CSGALNACT2	1	CSGALNACT2 [Golgi membrane] (R-HSA-1971506)	0.527	2
UniProt:P0DTC3 3a	9	O-glycosyl 3a [virion membrane] (R-COV-9694395) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9694729) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694386) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694658) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694716) 3a [endoplasmic reticulum lumen] (R-COV-9694584) O-glycosyl 3a [endolysosome membrane] (R-COV-9754541) O-glycosyl 3a [plasma membrane] (R-COV-9694433) O-glycosyl 3a [extracellular region] (R-COV-9694387)	0.463	2