Reactome | KCNJ2 [plasma membrane]

KCNJ2 [plasma membrane]

Stable Identifier

R-HSA-975378

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Inward rectifier potassium channel 2, IRK2_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Potassium Channels (Homo sapiens)
  - Inwardly rectifying K+ channels (Homo sapiens)
    - Classical Kir channels (Homo sapiens)
      - KCNJs transport K+ from the extracellular region to cytosol (Homo sapiens)
        
        KCNJ tetramer [plasma membrane] (Homo sapiens)
        
        KCNJs [plasma membrane] (Homo sapiens)
        
        KCNJ2 [plasma membrane] (Homo sapiens)
    - G protein gated Potassium channels (Homo sapiens)
      - Activation of G protein gated Potassium channels (Homo sapiens)
        
        Activation of GIRK/Kir3 Channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ2 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ2 [plasma membrane] (Homo sapiens)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ2 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ2 [plasma membrane] (Homo sapiens)
- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Homo sapiens)
        
        Activation of GIRK/Kir3 Channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ2 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ2 [plasma membrane] (Homo sapiens)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ2 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P63252 KCNJ2

Gene Names

KCNJ2, IRK1

Chain

initiator methionine:1, chain:2-427

Reference Genes

BioGPS Gene:3759 KCNJ2

COSMIC (genes):KCNJ2 KCNJ2

CTD Gene:3759 KCNJ2

dbSNP Gene:3759 KCNJ2

ENSEMBL:ENSG00000123700.5 KCNJ2

HGNC:6263 KCNJ2

KEGG Gene (Homo sapiens):3759 KCNJ2

Monarch:3759 KCNJ2

NCBI Gene:3759 KCNJ2

OMIM:600681 KCNJ2

UCSC:P63252 KCNJ2

Reference Transcript

RefSeq:NM_000891.2 KCNJ2

Other Identifiers

11730465_at

11730466_a_at

16837391

206765_PM_at

206765_at

36349_at

3733268

3733270

3733271

3733274

3733276

3733277

3733278

3733279

3733280

3759

48919_at

8009502

A_23_P329261

GE58967

GO:0003012

GO:0003013

GO:0005215

GO:0005242

GO:0005244

GO:0005515

GO:0005546

GO:0005783

GO:0005790

GO:0005791

GO:0005794

GO:0005886

GO:0006811

GO:0006813

GO:0008076

GO:0008289

GO:0014704

GO:0014861

GO:0015693

GO:0016020

GO:0016021

GO:0023052

GO:0030007

GO:0030315

GO:0030425

GO:0034765

GO:0042802

GO:0043025

GO:0043197

GO:0043226

GO:0045211

GO:0050877

GO:0051289

GO:0055065

GO:0055085

GO:0055119

GO:0060075

GO:0060306

GO:0065003

GO:0071260

GO:0071805

GO:0086001

GO:0086002

GO:0086004

GO:0086008

GO:0086011

GO:0086012

GO:0086013

GO:0086091

GO:0090076

GO:0098978

GO:1901381

GO:1990573

HMNXSV003048213

ILMN_1780334

PH_hs_0000207

TC17000813.hg

U16861_at

g8132296_3p_at

Participates

as a member of

KCNJs [plasma membrane] (Homo sapiens)

as a component of

Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)

Inferred To

IRK1 [plasma membrane] (Gallus gallus)

kcnj2 [plasma membrane] (Danio rerio)

kcnj2 [plasma membrane] (Xenopus tropicalis)

irk-2 [plasma membrane] (Caenorhabditis elegans)

Kcnj2 [plasma membrane] (Mus musculus)

Kcnj2 [plasma membrane] (Rattus norvegicus)

KCNJ2 [plasma membrane] (Bos taurus)

KCNJ2 [plasma membrane] (Canis familiaris)

KCNJ2 [plasma membrane] (Sus scrofa)

Irk1 [plasma membrane] (Drosophila melanogaster)

irk-3 [plasma membrane] (Caenorhabditis elegans)

Homologues of KCNJ2 [plasma membrane] (Caenorhabditis elegans)

Homologues of KCNJ2 [plasma membrane] (Drosophila melanogaster)

Irk3 [plasma membrane] (Drosophila melanogaster)

irk-1 [plasma membrane] (Caenorhabditis elegans)

Irk2 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_000882.1

Guide to Pharmacology - Targets

430

OpenTargets

ENSG00000123700

ZINC target

P63252

PRO

P63252

PDB

6SPZ, 7ZDZ

GeneCards

P63252

HPA

ENSG00000123700-KCNJ2

Ensembl

ENSP00000243457, ENSG00000123700, ENSP00000441848, ENST00000535240, ENST00000243457

Pharos - Targets

P63252

ZINC - Predictions - Purchasable

KCNJ2_HUMAN

Orphanet

16293

HMDB Protein

HMDBP02418

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:B7U540 KCJ18			0.659	4
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.659	4
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.571	2
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372)	0.556	3
UniProt:Q96IW7 SEC22A	3	SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111) SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562)	0.556	3
UniProt:Q99712 KCNJ15	1	KCNJ15 [plasma membrane] (R-HSA-975292)	0.556	3
UniProt:P63252 KCNJ2	1	KCNJ2 [plasma membrane] (R-HSA-975378)	0.556	3
UniProt:A0A0S2Z4U3 A0A0S2Z4U3			0.556	3
UniProt:P24588 AKAP5	2	AKAP5 [plasma membrane] (R-HSA-381669) AKAP5 [cytosol] (R-HSA-416331)	0.536	2