Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
KCNJ2 [plasma membrane]
Stable Identifier
R-HSA-975378
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Inward rectifier potassium channel 2, IRK2_HUMAN
Locations in the PathwayBrowser
Expand all
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Phase 4 - resting membrane potential (Homo sapiens)
KCNJs transport K+ from the extracellular region to cytosol (Homo sapiens)
KCNJ tetramer [plasma membrane] (Homo sapiens)
KCNJs [plasma membrane] (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Potassium Channels (Homo sapiens)
Inwardly rectifying K+ channels (Homo sapiens)
Classical Kir channels (Homo sapiens)
KCNJs transport K+ from the extracellular region to cytosol (Homo sapiens)
KCNJ tetramer [plasma membrane] (Homo sapiens)
KCNJs [plasma membrane] (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
G protein gated Potassium channels (Homo sapiens)
Activation of G protein gated Potassium channels (Homo sapiens)
Activation of GIRK/Kir3 Channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
GABA receptor activation (Homo sapiens)
GABA B receptor activation (Homo sapiens)
Activation of GABAB receptors (Homo sapiens)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Homo sapiens)
Activation of GIRK/Kir3 Channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
Sensory Perception (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sour taste (Homo sapiens)
KCNJ2 (KIR2.1) transports K+ from the extracellular region to the cytosol (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P63252 KCNJ2
Gene Names
KCNJ2, IRK1
Chain
initiator methionine:1, chain:2-427
Reference Genes
BioGPS Gene:3759 KCNJ2
COSMIC (genes):KCNJ2 KCNJ2
CTD Gene:3759 KCNJ2
dbSNP Gene:3759 KCNJ2
ENSEMBL:ENSG00000123700 KCNJ2
HGNC:6263 KCNJ2
KEGG Gene (Homo sapiens):3759 KCNJ2
Monarch:3759 KCNJ2
NCBI Gene:3759 KCNJ2
OMIM:600681 KCNJ2
UCSC:P63252 KCNJ2
Reference Transcript
RefSeq:NM_000891.2 KCNJ2
Other Identifiers
0005050253
11730465_at
11730466_a_at
16837391
206765_at
36349_at
3733268
3733270
3733271
3733274
3733276
3733277
3733278
3733279
3733280
3759
48919_at
8009502
A_23_P329261
GE58967
GO:0003013
GO:0003674
GO:0005242
GO:0005244
GO:0005515
GO:0005546
GO:0005575
GO:0005622
GO:0005737
GO:0005783
GO:0005790
GO:0005791
GO:0005794
GO:0005886
GO:0005887
GO:0006810
GO:0006811
GO:0006813
GO:0008076
GO:0008150
GO:0008289
GO:0014704
GO:0014861
GO:0015693
GO:0016020
GO:0016021
GO:0022607
GO:0022857
GO:0030007
GO:0030315
GO:0030425
GO:0031224
GO:0032991
GO:0034765
GO:0042592
GO:0042802
GO:0043025
GO:0043167
GO:0043197
GO:0043226
GO:0051289
GO:0055085
GO:0055119
GO:0060075
GO:0060306
GO:0061337
GO:0065003
GO:0071260
GO:0071805
GO:0086001
GO:0086002
GO:0086004
GO:0086008
GO:0086011
GO:0086012
GO:0086013
GO:0086091
GO:0090076
GO:1901381
GO:1990573
HMNXSV003048213
ILMN_1780334
PH_hs_0000207
TC17000813.hg
U16861_at
g8132296_3p_at
Participates
as a member of
KCNJs [plasma membrane] (Homo sapiens)
as a component of
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
Inferred To
IRK1 [plasma membrane]
(Gallus gallus)
kcnj2a [plasma membrane]
(Danio rerio)
irk-2 [plasma membrane]
(Caenorhabditis elegans)
Kcnj2 [plasma membrane]
(Mus musculus)
Kcnj2 [plasma membrane]
(Rattus norvegicus)
KCNJ2 [plasma membrane]
(Bos taurus)
KCNJ2 [plasma membrane]
(Canis familiaris)
KCNJ2 [plasma membrane]
(Xenopus tropicalis)
irk-3 [plasma membrane]
(Caenorhabditis elegans)
Homologues of KCNJ2 [plasma membrane]
(Caenorhabditis elegans)
Irk3 [plasma membrane]
(Drosophila melanogaster)
irk-1 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_000882.1
Guide to Pharmacology - Targets
430
OpenTargets
ENSG00000123700
ZINC target
P63252
PRO
P63252
GlyGen
P63252
PDB
6SPZ
GeneCards
P63252
HPA
ENSG00000123700-KCNJ2
Ensembl
ENST00000535240
,
ENSG00000123700
,
ENST00000243457
,
ENSP00000441848
,
ENSP00000243457
Pharos - Targets
P63252
Orphanet
16293
ZINC - Predictions - Purchasable
KCNJ2_HUMAN
HMDB Protein
HMDBP02418
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:B7U540 KCJ18
0.659
4
UniProt:Q3SXY8 ARL13B
8
PolyUb-Misfolded ARL13B [lysosomal lumen]
(R-HSA-9660004)
PolyUb-Misfolded ARL13B [cytosol]
(R-HSA-9641129)
Ub-Misfolded ARL13B [cytosol]
(R-HSA-9641119)
Misfolded ARL13B [cytosol]
(R-HSA-9640110)
Misfolded ARL13B [cilium]
(R-HSA-9640116)
ARL13B [cilium]
(R-HSA-5618181)
PolyUb-Misfolded ARL13B [late endosome lumen]
(R-HSA-9659986)
ARL13B [plasma membrane]
(R-HSA-9716787)
0.659
4
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.571
2
UniProt:Q96IW7 SEC22A
3
SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688562)
SEC22A [ER to Golgi transport vesicle membrane]
(R-HSA-5688560)
SEC22A [endoplasmic reticulum membrane]
(R-HSA-5216111)
0.556
3
UniProt:Q99712 KCNJ15
1
KCNJ15 [plasma membrane]
(R-HSA-975292)
0.556
3
UniProt:P63252 KCNJ2
1
KCNJ2 [plasma membrane]
(R-HSA-975378)
0.556
3
UniProt:A0A0S2Z4U3 A0A0S2Z4U3
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:P24588 AKAP5
2
AKAP5 [plasma membrane]
(R-HSA-381669)
AKAP5 [cytosol]
(R-HSA-416331)
0.536
2
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text