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KCNJ2 [plasma membrane]
Stable Identifier
R-HSA-975378
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Inward rectifier potassium channel 2, IRK2_HUMAN
Locations in the PathwayBrowser
Expand all
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Phase 4 - resting membrane potential (Homo sapiens)
KCNJs transport K+ from the extracellular region to cytosol (Homo sapiens)
KCNJ tetramer [plasma membrane] (Homo sapiens)
KCNJs [plasma membrane] (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Potassium Channels (Homo sapiens)
Inwardly rectifying K+ channels (Homo sapiens)
Classical Kir channels (Homo sapiens)
KCNJs transport K+ from the extracellular region to cytosol (Homo sapiens)
KCNJ tetramer [plasma membrane] (Homo sapiens)
KCNJs [plasma membrane] (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
G protein gated Potassium channels (Homo sapiens)
Activation of G protein gated Potassium channels (Homo sapiens)
Activation of GIRK/Kir3 Channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
GABA receptor activation (Homo sapiens)
GABA B receptor activation (Homo sapiens)
Activation of GABAB receptors (Homo sapiens)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Homo sapiens)
Activation of GIRK/Kir3 Channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
Sensory Perception (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sour taste (Homo sapiens)
KCNJ2 (KIR2.1) transports K+ from the extracellular region to the cytosol (Homo sapiens)
KCNJ2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P63252 KCNJ2
Gene Names
KCNJ2, IRK1
Chain
initiator methionine:1, chain:2-427
Reference Genes
BioGPS Gene:3759 KCNJ2
COSMIC (genes):KCNJ2 KCNJ2
CTD Gene:3759 KCNJ2
dbSNP Gene:3759 KCNJ2
ENSEMBL:ENSG00000123700.5 KCNJ2
HGNC:6263 KCNJ2
KEGG Gene (Homo sapiens):3759 KCNJ2
Monarch:3759 KCNJ2
NCBI Gene:3759 KCNJ2
OMIM:600681 KCNJ2
UCSC:P63252 KCNJ2
Reference Transcript
RefSeq:NM_000891.2 KCNJ2
Other Identifiers
11730465_at
11730466_a_at
16837391
206765_PM_at
206765_at
36349_at
3733268
3733270
3733271
3733274
3733276
3733277
3733278
3733279
3733280
3759
48919_at
8009502
A_23_P329261
GE58967
GO:0003012
GO:0003013
GO:0005215
GO:0005242
GO:0005244
GO:0005515
GO:0005546
GO:0005783
GO:0005790
GO:0005791
GO:0005794
GO:0005886
GO:0006811
GO:0006813
GO:0008076
GO:0008289
GO:0014704
GO:0014861
GO:0015693
GO:0016020
GO:0016021
GO:0023052
GO:0030007
GO:0030315
GO:0030425
GO:0034765
GO:0042802
GO:0043025
GO:0043197
GO:0043226
GO:0045211
GO:0050877
GO:0051289
GO:0055065
GO:0055085
GO:0055119
GO:0060075
GO:0060306
GO:0065003
GO:0071260
GO:0071805
GO:0086001
GO:0086002
GO:0086004
GO:0086008
GO:0086011
GO:0086012
GO:0086013
GO:0086091
GO:0090076
GO:0098978
GO:1901381
GO:1990573
HMNXSV003048213
ILMN_1780334
PH_hs_0000207
TC17000813.hg
U16861_at
g8132296_3p_at
Participates
as a member of
KCNJs [plasma membrane] (Homo sapiens)
as a component of
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
Inferred To
IRK1 [plasma membrane]
(Gallus gallus)
kcnj2 [plasma membrane]
(Danio rerio)
kcnj2 [plasma membrane]
(Xenopus tropicalis)
irk-2 [plasma membrane]
(Caenorhabditis elegans)
Kcnj2 [plasma membrane]
(Mus musculus)
Kcnj2 [plasma membrane]
(Rattus norvegicus)
KCNJ2 [plasma membrane]
(Bos taurus)
KCNJ2 [plasma membrane]
(Canis familiaris)
KCNJ2 [plasma membrane]
(Sus scrofa)
Irk1 [plasma membrane]
(Drosophila melanogaster)
irk-3 [plasma membrane]
(Caenorhabditis elegans)
Homologues of KCNJ2 [plasma membrane]
(Caenorhabditis elegans)
Homologues of KCNJ2 [plasma membrane]
(Drosophila melanogaster)
Irk3 [plasma membrane]
(Drosophila melanogaster)
irk-1 [plasma membrane]
(Caenorhabditis elegans)
Irk2 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_000882.1
Guide to Pharmacology - Targets
430
OpenTargets
ENSG00000123700
ZINC target
P63252
PRO
P63252
PDB
6SPZ
,
7ZDZ
GeneCards
P63252
HPA
ENSG00000123700-KCNJ2
Ensembl
ENSP00000243457
,
ENSG00000123700
,
ENSP00000441848
,
ENST00000535240
,
ENST00000243457
Pharos - Targets
P63252
ZINC - Predictions - Purchasable
KCNJ2_HUMAN
Orphanet
16293
HMDB Protein
HMDBP02418
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:B7U540 KCJ18
0.659
4
UniProt:Q3SXY8 ARL13B
8
PolyUb-Misfolded ARL13B [lysosomal lumen]
(R-HSA-9660004)
PolyUb-Misfolded ARL13B [cytosol]
(R-HSA-9641129)
Ub-Misfolded ARL13B [cytosol]
(R-HSA-9641119)
Misfolded ARL13B [cytosol]
(R-HSA-9640110)
Misfolded ARL13B [cilium]
(R-HSA-9640116)
ARL13B [cilium]
(R-HSA-5618181)
PolyUb-Misfolded ARL13B [late endosome lumen]
(R-HSA-9659986)
ARL13B [plasma membrane]
(R-HSA-9716787)
0.659
4
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.571
2
UniProt:O00560 SDCBP
3
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
0.556
3
UniProt:Q96IW7 SEC22A
3
SEC22A [ER to Golgi transport vesicle membrane]
(R-HSA-5688560)
SEC22A [endoplasmic reticulum membrane]
(R-HSA-5216111)
SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688562)
0.556
3
UniProt:Q99712 KCNJ15
1
KCNJ15 [plasma membrane]
(R-HSA-975292)
0.556
3
UniProt:P63252 KCNJ2
1
KCNJ2 [plasma membrane]
(R-HSA-975378)
0.556
3
UniProt:A0A0S2Z4U3 A0A0S2Z4U3
0.556
3
UniProt:P24588 AKAP5
2
AKAP5 [plasma membrane]
(R-HSA-381669)
AKAP5 [cytosol]
(R-HSA-416331)
0.536
2
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