Reactome | LPAR6 [plasma membrane]

LPAR6 [plasma membrane]

Stable Identifier

R-HSA-417913

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

P2RY5, P2Y5 receptor, Oleoyl-L-alpha-lysophosphatidic acid receptor, P2RY5_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P43657 LPAR6

Gene Names

LPAR6, P2RY5

Chain

chain:1-344

Reference Genes

BioGPS Gene:10161 LPAR6

COSMIC (genes):LPAR6 LPAR6

CTD Gene:10161 LPAR6

dbSNP Gene:10161 LPAR6

ENSEMBL:ENSG00000139679 LPAR6

HGNC:15520 LPAR6

KEGG:hsa:10161 LPAR6

Monarch:10161 LPAR6

NCBI Gene:10161 LPAR6

OMIM:609239 LPAR6

UCSC:P43657 LPAR6

Reference Transcript

Other Identifiers

10161

11743071_a_at

1557763_PM_at

1557763_at

16779006

218589_PM_at

218589_at

3513515

3513516

3513517

3513519

3513520

3513521

3513522

3513523

3513524

3513525

3513526

3513527

3513528

3513529

3513530

3513531

3513532

3513533

3513534

3513535

3513536

3513537

3513538

3513539

3513540

3513541

3513542

3513543

3513544

3513545

3513547

3513548

75361_r_at

76580_at

76582_g_at

76584_r_at

7971565

A_23_P2705

GE61767

GO:0001835

GO:0004930

GO:0005515

GO:0005886

GO:0007186

GO:0007200

GO:0016020

GO:0035025

GO:0060089

GO:0070915

HMNXSV003052211

HMNXSV003054382

Hs2.123464.1.S1_3p_at

Hs2.123464.1.S1_3p_s_at

ILMN_1786429

PH_hs_0022368

TC13001488.hg

g5031968_3p_at

Participates

as an input of

P2Y5 receptor can bind to LPA (Homo sapiens)

as a member of

GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)

as a component of

P2RY5:LPA [plasma membrane] (Homo sapiens)

Inferred To

lpar6a [plasma membrane] (Danio rerio)

LOC119865171 [plasma membrane] (Canis familiaris)

LPAR6 [plasma membrane] (Bos taurus)

LPAR6 [plasma membrane] (Canis familiaris)

LPAR6 [plasma membrane] (Sus scrofa)

Lpar6 [plasma membrane] (Mus musculus)

Lpar6 [plasma membrane] (Rattus norvegicus)

lpar6 [plasma membrane] (Xenopus tropicalis)

gnrr-4 [plasma membrane] (Caenorhabditis elegans)

Homologues of LPAR6 [plasma membrane] (Canis familiaris)

Cross References

RefSeq

NP_001155969.1, NP_005758.2, NP_001155970.1

Guide to Pharmacology - Targets

163

OpenTargets

ENSG00000139679

ENSEMBL

ENSP00000367691, ENST00000620633, ENST00000345941, ENSP00000482660, ENSP00000344353, ENST00000378434

ZINC - Substances

LPAR6_HUMAN

ZINC - Biogenic

LPAR6_HUMAN

ZINC target

P43657

PRO

P43657

GlyGen

P43657

ZINC - Metabolites

LPAR6_HUMAN

HPA

ENSG00000139679-LPAR6

Pharos - Targets

P43657

Orphanet

LPAR6

ZINC - Predictions - Purchasable

LPAR6_HUMAN

HMDB Protein

HMDBP07316

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BZL3 SMIM3			0.556	3
UniProt:Q9NS64 RPRM			0.556	3
UniProt:Q96IW7 SEC22A	3	SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111)	0.556	3
UniProt:P54849 EMP1			0.556	3
UniProt:Q96QD8 SLC38A2	1	SLC38A2 [plasma membrane] (R-HSA-352093)	0.527	2
UniProt:P23458 JAK1	6	p-Y-JAK1 [cytosol] (R-HSA-451921) JAK1 [cytosol] (R-HSA-451898) p-Y1034-JAK1 [cytosol] (R-HSA-1112543) p-JAK1 [cytosol] (R-HSA-8950711) JAK1 [endosome] (R-HSA-8983168) p-Y1034,Y1035-JAK1 [cytosol] (R-HSA-9005335)	0.527	2
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009) CAV1 [early endosome membrane] (R-HSA-5368451)	0.527	2
UniProt:P11532 DMD	1	DMD [cytosol] (R-HSA-390567)	0.527	2
UniProt:Q9BYI3 HYCCI			0.527	2
UniProt:Q96D31 ORAI1	1	ORAI1 [plasma membrane] (R-HSA-434672)	0.527	2
UniProt:Q8TD22 SFXN5			0.527	2
UniProt:O95858 TSPAN15	2	TSPAN15 [plasma membrane] (R-HSA-9010043) TSPAN15 [endoplasmic reticulum lumen] (R-HSA-9010117)	0.527	2
UniProt:Q68DH5 LMBD2			0.527	2
UniProt:Q6DD88 ATLA3			0.527	2