Reactome | p-Y63,Y79,Y110-TRAT1 [plasma membrane]

p-Y63,Y79,Y110-TRAT1 [plasma membrane]

Stable Identifier

R-HSA-202201

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Phospho TRAT

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        PI3K bound to TRAT [plasma membrane] (Homo sapiens)
        
        p-Y63,Y79,Y110-TRAT1 [plasma membrane] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        PI3K bound to TRAT [plasma membrane] (Homo sapiens)
        
        p-Y63,Y79,Y110-TRAT1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6PIZ9 TRAT1

Gene Names

TRAT1, TCRIM, HSPC062

Chain

chain:1-186

Reference Genes

BioGPS Gene:50852 TRAT1

COSMIC (genes):TRAT1 TRAT1

CTD Gene:50852 TRAT1

dbSNP Gene:50852 TRAT1

ENSEMBL:ENSG00000163519 TRAT1

HGNC:30698 TRAT1

KEGG:hsa:50852 TRAT1

Monarch:50852 TRAT1

NCBI Gene:50852 TRAT1

OMIM:604962 TRAT1

UCSC:Q6PIZ9 TRAT1

Reference Transcript

Other Identifiers

11734050_a_at

11734051_a_at

16943719

217147_3p_s_at

217147_PM_s_at

217147_s_at

2635354

2635356

2635357

2635360

2635361

2635364

2635365

2635366

2635367

2635371

33039_at

50852

8081537

A_23_P212568

GE82116

GO:0001920

GO:0002250

GO:0002376

GO:0005068

GO:0005515

GO:0005886

GO:0006968

GO:0007165

GO:0007169

GO:0034451

GO:0042101

GO:0043226

GO:0050850

GO:0050862

GO:0051051

GO:0060090

GO:0072686

HMNXSV003004399

Hs.138701.1.S1_3p_s_at

ILMN_1684943

ILMN_2124833

PH_hs_0031781

TC03000549.hg

Participates

as an input of

Recruitment of PI3K to plasma membrane (Homo sapiens)

as a component of

PI3K bound to TRAT [plasma membrane] (Homo sapiens)

Inferred To

phospho-p-Y63,Y79,Y110-TRAT1 [plasma membrane] (Sus scrofa)

phospho-Trat1 [plasma membrane] (Mus musculus)

phospho-Trat1 [plasma membrane] (Rattus norvegicus)

phospho-TRAT1 [plasma membrane] (Bos taurus)

phospho-TRAT1 [plasma membrane] (Canis familiaris)

phospho-TRAT1 [plasma membrane] (Gallus gallus)

Modified Residues

Name

O4'-phospho-L-tyrosine at 63

Coordinate

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 79

Coordinate

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 110

Coordinate

110

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001304676.1, NP_057472.2

ENSEMBL

ENSP00000295756, ENST00000295756

OpenTargets

ENSG00000163519

HPA

ENSG00000163519-TRAT1

PRO

Q6PIZ9

Pharos - Targets

Q6PIZ9

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96IW7 SEC22A	3	SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111)	0.556	3