Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
S1PR1 [plasma membrane]
Stable Identifier
R-HSA-419340
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Sphingosine 1-phosphate receptor 1, S1PR1_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
S1PR1 binds S1PR1 agonists (Homo sapiens)
S1PR1 [plasma membrane] (Homo sapiens)
S1PR1:S1PR1 agonists [plasma membrane] (Homo sapiens)
S1PR1 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated plasma membrane proteins (Homo sapiens)
STAT3-upregulated plasma membrane proteins [plasma membrane] (Homo sapiens)
S1PR1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Lysosphingolipid and LPA receptors (Homo sapiens)
S1PR1 bind S1P (Homo sapiens)
S1PR1 [plasma membrane] (Homo sapiens)
S1PR1:S1P [plasma membrane] (Homo sapiens)
S1PR1 [plasma membrane] (Homo sapiens)
S1PR1:S1PR1 agonists [plasma membrane] (Homo sapiens)
S1PR1 [plasma membrane] (Homo sapiens)
S1PR1 binds S1PR1 agonists (Homo sapiens)
S1PR1 [plasma membrane] (Homo sapiens)
S1PR1:S1PR1 agonists [plasma membrane] (Homo sapiens)
S1PR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P21453 S1PR1
Gene Names
S1PR1, CHEDG1, EDG1
Chain
chain:1-382
Reference Genes
BioGPS Gene:1901 S1PR1
COSMIC (genes):S1PR1 S1PR1
CTD Gene:1901 S1PR1
dbSNP Gene:1901 S1PR1
ENSEMBL:ENSG00000170989 S1PR1
HGNC:3165 S1PR1
KEGG:hsa:1901 S1PR1
Monarch:1901 S1PR1
NCBI Gene:1901 S1PR1
OMIM:601974 S1PR1
UCSC:P21453 S1PR1
Reference Transcript
RefSeq:NM_001320730.1 S1PR1
RefSeq:NM_001400.4 S1PR1
Other Identifiers
11743815_a_at
11743816_s_at
11752382_a_at
16667760
1901
204642_PM_at
204642_at
2349138
2349139
2349140
2349141
2349142
2349143
2349144
2349145
2349146
2349147
2349148
2349150
2349151
2349152
239401_PM_at
239401_at
240025_PM_x_at
240025_x_at
587_at
75159_at
7903393
A_14_P109978
A_23_P404481
GE536265
GE57920
GO:0001525
GO:0001664
GO:0001955
GO:0002376
GO:0003245
GO:0003376
GO:0004930
GO:0005515
GO:0005654
GO:0005737
GO:0005768
GO:0005886
GO:0006355
GO:0006935
GO:0007010
GO:0007155
GO:0007186
GO:0007189
GO:0007193
GO:0007200
GO:0007420
GO:0008283
GO:0008284
GO:0008289
GO:0009897
GO:0016020
GO:0016477
GO:0019222
GO:0019226
GO:0030032
GO:0030036
GO:0030154
GO:0030155
GO:0030182
GO:0030335
GO:0030500
GO:0030595
GO:0031410
GO:0038036
GO:0043226
GO:0043231
GO:0045121
GO:0045124
GO:0045446
GO:0045944
GO:0046625
GO:0048661
GO:0048856
GO:0048870
GO:0050877
GO:0050927
GO:0051497
GO:0060089
GO:0061384
GO:0072678
GO:0098793
HMNXSV003014977
HMNXSV003052715
Hs.137293.0.A1_3p_at
Hs.15630.0.A1_3p_x_at
ILMN_1653504
ILMN_1884357
PH_hs_0008282
PH_hs_0009283
TC01000909.hg
TC01004570.hg
p1082
Participates
as a member of
STAT3-upregulated plasma membrane proteins [plasma membrane] (Homo sapiens)
as a component of
S1PR1:S1P [plasma membrane] (Homo sapiens)
S1PR1:S1PR1 agonists [plasma membrane] (Homo sapiens)
as an input of
S1PR1 bind S1P (Homo sapiens)
S1PR1 binds S1PR1 agonists (Homo sapiens)
Inferred To
s1pr1 [plasma membrane]
(Xenopus tropicalis)
S1PR1 [plasma membrane]
(Bos taurus)
S1PR1 [plasma membrane]
(Canis familiaris)
S1PR1 [plasma membrane]
(Danio rerio)
S1PR1 [plasma membrane]
(Gallus gallus)
S1PR1 [plasma membrane]
(Mus musculus)
S1PR1 [plasma membrane]
(Rattus norvegicus)
S1PR1 [plasma membrane]
(Sus scrofa)
Cross References
Guide to Pharmacology - Targets
275
OpenTargets
ENSG00000170989
ENSEMBL
ENST00000649383
,
ENSP00000497478
,
ENSP00000497175
,
ENST00000475289
,
ENST00000648480
,
ENSP00000498038
,
ENST00000305352
,
ENSG00000170989
,
ENSP00000305416
ZINC - FDA approved
S1PR1_HUMAN
ZINC - Substances
S1PR1_HUMAN
ZINC - Biogenic
S1PR1_HUMAN
ZINC target
P21453
PRO
P21453
GlyGen
P21453
PDB
7TD4
,
7EW0
,
7EW7
,
7VIG
,
7VIF
,
7VIH
,
7EVZ
,
7EVY
,
3V2Y
,
8G94
,
7WF7
,
3V2W
,
7VIE
,
7EO4
,
7EO2
,
7TD3
ZINC - Investigational
S1PR1_HUMAN
ZINC - Metabolites
S1PR1_HUMAN
HPA
ENSG00000170989-S1PR1
GeneCards
S1PR1
Pharos - Targets
P21453
ZINC - Predictions - Purchasable
S1PR1_HUMAN
HMDB Protein
HMDBP02679
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7Z2K8 GPRIN1
1
GPRIN1 [plasma membrane]
(R-HSA-9022059)
0.527
3
UniProt:P13637 ATP1A3
1
ATP1A3 [plasma membrane]
(R-HSA-936803)
0.527
4
UniProt:P11117 PPAL
0.527
4
UniProt:Q07108 CD69
0.524
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text