Reactome | S1PR1 [plasma membrane]

S1PR1

Stable Identifier

R-HSA-419340

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Sphingosine 1-phosphate receptor 1, S1PR1_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        S1PR1-5:S1P [plasma membrane] (Homo sapiens)
        
        S1PR1-5 [plasma membrane] (Homo sapiens)
        
        S1PR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        S1PR1-5:S1P [plasma membrane] (Homo sapiens)
        
        S1PR1-5 [plasma membrane] (Homo sapiens)
        
        S1PR1 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        S1PR1-5:S1P [plasma membrane] (Homo sapiens)
        
        S1PR1-5 [plasma membrane] (Homo sapiens)
        
        S1PR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        S1PR1-5:S1P [plasma membrane] (Homo sapiens)
        
        S1PR1-5 [plasma membrane] (Homo sapiens)
        
        S1PR1 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        GPCRs that activate Gi [plasma membrane] (Homo sapiens)
        
        S1PR1-5 [plasma membrane] (Homo sapiens)
        
        S1PR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        S1PR1-5:S1P [plasma membrane] (Homo sapiens)
        
        S1PR1-5 [plasma membrane] (Homo sapiens)
        
        S1PR1 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Lysosphingolipid and LPA receptors (Homo sapiens)
        
        S1P-binding receptors bind S1P (Homo sapiens)
        
        S1PR1-5 [plasma membrane] (Homo sapiens)
        
        S1PR1 [plasma membrane] (Homo sapiens)
        
        S1PR1-5:S1P [plasma membrane] (Homo sapiens)
        
        S1PR1-5 [plasma membrane] (Homo sapiens)
        
        S1PR1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P21453 S1PR1

Gene Names

S1PR1, CHEDG1, EDG1

Chain

chain:1-382

Reference Genes

BioGPS Gene:1901 S1PR1

COSMIC (genes):S1PR1 S1PR1

CTD Gene:1901 S1PR1

dbSNP Gene:1901 S1PR1

ENSEMBL:ENSG00000170989 S1PR1

HGNC:3165 S1PR1

KEGG Gene (Homo sapiens):hsa:1901 S1PR1

Monarch:1901 S1PR1

NCBI Gene:1901 S1PR1

OMIM:601974 S1PR1

UCSC:P21453 S1PR1

Reference Transcript

Other Identifiers

10104

11743815_a_at

11743816_s_at

11752382_a_at

16667760

1901

204642_at

2349139

2349140

2349143

2349144

2349145

2349146

2349147

2349148

3V2W

3V2Y

587_at

75568

7903393

A_14_P109978

A_23_P404481

AAA52336

AAC51905

AAF43420

AAH18650

AF022137

AF233365

AK312493

AL109741

BAG35395

BC018650

CAB010104

CAG46585

CAG47065

CCDS777

CH471097

CR541786

CR542269

EAW72927

EAW72928

ENSG00000170989

ENSP00000305416

ENST00000305352

EntrezGene:1901

GE57920

GO:0001525

GO:0001664

GO:0001955

GO:0002376

GO:0003245

GO:0003376

GO:0003674

GO:0004871

GO:0004930

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005886

GO:0006935

GO:0007010

GO:0007155

GO:0007165

GO:0007186

GO:0007193

GO:0007420

GO:0008150

GO:0008283

GO:0008284

GO:0008289

GO:0009058

GO:0009897

GO:0016020

GO:0016021

GO:0016477

GO:0019221

GO:0019226

GO:0021700

GO:0022607

GO:0030032

GO:0030154

GO:0030155

GO:0030182

GO:0030335

GO:0030500

GO:0030595

GO:0031226

GO:0031410

GO:0031532

GO:0034641

GO:0038036

GO:0040007

GO:0040011

GO:0042592

GO:0043226

GO:0043231

GO:0043547

GO:0045121

GO:0045124

GO:0045446

GO:0045944

GO:0046625

GO:0048646

GO:0048661

GO:0048856

GO:0048870

GO:0050877

GO:0050927

GO:0051482

GO:0051497

GO:0061384

GO:0072678

HGNC:3165

HPA075568

ILMN_1653504

ILMN_3235853

IPR000276

IPR000987

IPR004061

IPR017452

M31210

MIM:601974

NM_001320730

NM_001400

NP_001307659

NP_001391

PF00001

PH_hs_0009283

PR00237

PR00642

PR01523

S1PR1

S1PR1-201

SM01381

TC01000909.hg

uc001dud.3

UPI0000050421

Participant Of

hasMember

Inferred To

S1PR1 [plasma membrane] (Bos taurus)

S1PR1 [plasma membrane] (Canis familiaris)

S1PR1 [plasma membrane] (Danio rerio)

S1PR1 [plasma membrane] (Gallus gallus)

S1PR1 [plasma membrane] (Mus musculus)

S1PR1 [plasma membrane] (Rattus norvegicus)

S1PR1 [plasma membrane] (Sus scrofa)

S1PR1 [plasma membrane] (Taeniopygia guttata)

S1PR1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001391.2, NP_001307659.1

ZINC - Metabolites

S1PR1_HUMAN

ZINC - World Drugs

S1PR1_HUMAN

ZINC - FDA approved

S1PR1_HUMAN

GeneCards

P21453

ZINC - Substances

S1PR1_HUMAN

ZINC target

P21453

ZINC - Biogenic

S1PR1_HUMAN

PRO

P21453

ZINC - Predictions - Purchasable

S1PR1_HUMAN

HMDB Protein

HMDBP02679

PDB

3V2W, 3V2Y