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AIM2 [cytosol]
Stable Identifier
R-HSA-874111
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Interferon-inducible protein AIM2, AIM2_HUMAN, Absent in melanoma 2
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
AIM2 binds dsDNA (Homo sapiens)
AIM2 [cytosol] (Homo sapiens)
dsDNA:AIM2 [cytosol] (Homo sapiens)
AIM2 [cytosol] (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The AIM2 inflammasome (Homo sapiens)
AIM2 binds dsDNA (Homo sapiens)
AIM2 [cytosol] (Homo sapiens)
dsDNA:AIM2 [cytosol] (Homo sapiens)
AIM2 [cytosol] (Homo sapiens)
AIM2 oligomerizes (Homo sapiens)
dsDNA:AIM2 [cytosol] (Homo sapiens)
AIM2 [cytosol] (Homo sapiens)
dsDNA:AIM2 oligomer [cytosol] (Homo sapiens)
dsDNA:AIM2 [cytosol] (Homo sapiens)
AIM2 [cytosol] (Homo sapiens)
dsDNA:AIM2 clusters bind ASC (Homo sapiens)
dsDNA:AIM2 oligomer [cytosol] (Homo sapiens)
dsDNA:AIM2 [cytosol] (Homo sapiens)
AIM2 [cytosol] (Homo sapiens)
dsDNA:AIM2 oligomer:ASC [cytosol] (Homo sapiens)
dsDNA:AIM2 oligomer [cytosol] (Homo sapiens)
dsDNA:AIM2 [cytosol] (Homo sapiens)
AIM2 [cytosol] (Homo sapiens)
dsDNA:AIM2:ASC cluster binds procaspase-1 (Homo sapiens)
dsDNA:AIM2 oligomer:ASC [cytosol] (Homo sapiens)
dsDNA:AIM2 oligomer [cytosol] (Homo sapiens)
dsDNA:AIM2 [cytosol] (Homo sapiens)
AIM2 [cytosol] (Homo sapiens)
dsDNA:AIM2 oligomer:ASC:Procaspase-1 [cytosol] (Homo sapiens)
dsDNA:AIM2 oligomer:ASC [cytosol] (Homo sapiens)
dsDNA:AIM2 oligomer [cytosol] (Homo sapiens)
dsDNA:AIM2 [cytosol] (Homo sapiens)
AIM2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14862 AIM2
Gene Names
AIM2
Chain
chain:1-343
Reference Genes
BioGPS Gene:9447 AIM2
COSMIC (genes):AIM2 AIM2
CTD Gene:9447 AIM2
dbSNP Gene:9447 AIM2
ENSEMBL:ENSG00000163568 AIM2
HGNC:357 AIM2
KEGG Gene (Homo sapiens):9447 AIM2
Monarch:9447 AIM2
NCBI Gene:9447 AIM2
OMIM:604578 AIM2
UCSC:O14862 AIM2
Reference Transcript
RefSeq:XM_017002848.1 AIM2
RefSeq:NM_004833.2 AIM2
Other Identifiers
0006650441
11730457_a_at
11730458_at
16695121
206513_PM_at
206513_at
2439555
2439556
2439559
2439561
2439562
2439563
2439565
2439566
2439567
2439568
2439569
2439571
34439_at
7921434
9447
A_32_P44394
GE54190
GO:0002218
GO:0002221
GO:0002230
GO:0002376
GO:0003674
GO:0003677
GO:0003690
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0006915
GO:0006950
GO:0006954
GO:0006955
GO:0007165
GO:0008150
GO:0008219
GO:0009058
GO:0022607
GO:0032088
GO:0032731
GO:0032991
GO:0033209
GO:0034641
GO:0035458
GO:0042802
GO:0043226
GO:0044546
GO:0045087
GO:0050729
GO:0051092
GO:0051607
GO:0065003
GO:0070269
GO:0071466
GO:0097169
GO:1904270
GO:2001056
HMNXSV003010367
HMNXSV003041218
ILMN_1681301
ILMN_2214232
PH_hs_0005844
TC01003383.hg
g4757733_3p_at
Participates
as an input of
AIM2 binds dsDNA (Homo sapiens)
as a component of
dsDNA:AIM2 [cytosol] (Homo sapiens)
Inferred To
Aim2 [cytosol]
(Mus musculus)
Aim2 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_004824.1
,
XP_016858337.1
Guide to Pharmacology - Targets
2923
OpenTargets
ENSG00000163568
HPA
ENSG00000163568-AIM2
GeneCards
O14862
Ensembl
ENSP00000357112
,
ENSG00000163568
,
ENST00000368130
PRO
O14862
Pharos - Targets
O14862
PDB
4O7Q
,
7K3R
,
6MB2
,
3RN2
,
3VD8
,
3RN5
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9ULZ3 PYCARD
4
PYCARD [cytosol]
(R-HSA-561191)
PYCARD [secretory granule lumen]
(R-HSA-6800957)
PYCARD [extracellular region]
(R-HSA-6806196)
PYCARD [azurophil granule lumen]
(R-HSA-6798768)
0.892
13
UniProt:O14862 AIM2
1
AIM2 [cytosol]
(R-HSA-874111)
0.656
3
UniProt:P29466 CASP1
5
CASP1(1-119) [cytosol]
(R-HSA-448680)
CASP1(298-316) [cytosol]
(R-HSA-448674)
CASP1(120-297) [cytosol]
(R-HSA-448686)
CASP1(317-404) [cytosol]
(R-HSA-448704)
CASP1(1-404) [cytosol]
(R-HSA-448692)
0.488
2
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