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NLRP1 [cytosol]
Stable Identifier
R-HSA-561196
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NACHT, LRR and PYD domains-containing protein 1, NALP1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The NLRP1 inflammasome (Homo sapiens)
Bcl-2 and Bcl-XL bind NLRP1 (Homo sapiens)
Bcl-2/Bcl-X(L):NLRP1 [mitochondrial outer membrane] (Homo sapiens)
NLRP1 [cytosol] (Homo sapiens)
NLRP1 [cytosol] (Homo sapiens)
MDP:NLRP1 binds ATP (Homo sapiens)
MDP:NLRP1 [cytosol] (Homo sapiens)
NLRP1 [cytosol] (Homo sapiens)
MDP:NLRP1:ATP [cytosol] (Homo sapiens)
MDP:NLRP1 [cytosol] (Homo sapiens)
NLRP1 [cytosol] (Homo sapiens)
NLRP1 oligomerizes (Homo sapiens)
MDP:NLRP1:ATP [cytosol] (Homo sapiens)
MDP:NLRP1 [cytosol] (Homo sapiens)
NLRP1 [cytosol] (Homo sapiens)
MDP:NLRP1:ATP oligomer [cytosol] (Homo sapiens)
MDP:NLRP1:ATP [cytosol] (Homo sapiens)
MDP:NLRP1 [cytosol] (Homo sapiens)
NLRP1 [cytosol] (Homo sapiens)
NLRP1 senses MDP (Homo sapiens)
MDP:NLRP1 [cytosol] (Homo sapiens)
NLRP1 [cytosol] (Homo sapiens)
NLRP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9C000 NLRP1
Gene Names
NLRP1, CARD7, DEFCAP, KIAA0926, NAC, NALP1
Chain
chain:1-1473, chain:1-1212, chain:1213-1473
Reference Genes
BioGPS Gene:22861 NLRP1
COSMIC (genes):NLRP1 NLRP1
CTD Gene:22861 NLRP1
dbSNP Gene:22861 NLRP1
ENSEMBL:ENSG00000091592.16 NLRP1
HGNC:14374 NLRP1
KEGG Gene (Homo sapiens):22861 NLRP1
Monarch:22861 NLRP1
NCBI Gene:22861 NLRP1
OMIM:606636 NLRP1
UCSC:Q9C000 NLRP1
Reference Transcript
RefSeq:NM_033004.3 NLRP1
RefSeq:NM_033007.3 NLRP1
RefSeq:NM_014922.4 NLRP1
RefSeq:NM_001033053.2 NLRP1
RefSeq:NM_033006.3 NLRP1
Other Identifiers
0004610138
0007000725
0106400037
11731879_a_at
11731880_at
11737423_a_at
11744351_a_at
16840318
16840321
210113_PM_s_at
210113_s_at
211822_PM_s_at
211822_s_at
211824_PM_x_at
211824_x_at
218380_PM_at
218380_at
22861
37127_at
3742784
3742785
3742794
3742795
3742796
3742797
3742798
3742799
3742800
3742801
3742802
3742803
3742812
3742813
3742814
3742815
3742816
3742817
3742818
3742819
3742821
3742824
3742826
3742829
3742831
3742832
3742833
3742834
3742836
3742839
3742841
3742845
3742846
3742847
3742848
3742849
3742850
3742851
3742852
3742855
3742856
3742857
3742858
3742859
3742860
57214_at
59284_at
8011884
A_23_P107351
A_23_P89550
A_24_P83615
A_33_P3331491
GE53606
GO:0000166
GO:0002221
GO:0002376
GO:0003677
GO:0003690
GO:0003723
GO:0003725
GO:0005515
GO:0005524
GO:0005622
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006508
GO:0006915
GO:0006919
GO:0006954
GO:0008233
GO:0008656
GO:0012501
GO:0016787
GO:0016887
GO:0019899
GO:0019904
GO:0023052
GO:0032495
GO:0032731
GO:0032991
GO:0042742
GO:0042981
GO:0043226
GO:0043621
GO:0045087
GO:0048583
GO:0050727
GO:0050729
GO:0051260
GO:0051402
GO:0051607
GO:0061702
GO:0065003
GO:0070269
GO:0072558
GO:0097264
GO:0098542
GO:0098772
GO:0140096
GO:0140374
GO:0140608
GO:0140657
GO:1904784
HMNXSV003022422
HMNXSV003045369
ILMN_1680774
ILMN_1810045
ILMN_2313079
PH_hs_0026678
PH_hs_0031490
TC01003625.hg
TC17001059.hg
g11096302_3p_s_at
g11119423_3p_at
g12656108_3p_s_at
Participates
as a component of
Bcl-2/Bcl-X(L):NLRP1 [mitochondrial outer membrane] (Homo sapiens)
MDP:NLRP1 [cytosol] (Homo sapiens)
as an input of
Bcl-2 and Bcl-XL bind NLRP1 (Homo sapiens)
NLRP1 senses MDP (Homo sapiens)
Inferred To
Homologues of NLRP1 [cytosol]
(Danio rerio)
CARD8 [cytosol]
(Gallus gallus)
Gene2604 [cytosol]
(Danio rerio)
pycard [cytosol]
(Danio rerio)
NLRP1 [cytosol]
(Bos taurus)
NLRP1 [cytosol]
(Canis familiaris)
NLRP1 [cytosol]
(Danio rerio)
NLRP1 [cytosol]
(Mus musculus)
NLRP1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_055737.1
,
NP_127497.1
,
NP_127500.1
,
NP_001028225.1
,
NP_127499.1
Guide to Pharmacology - Targets
1768
OpenTargets
ENSG00000091592
HPA
ENSG00000091592-NLRP1
GeneCards
Q9C000
Ensembl
ENSP00000478516
,
ENSP00000442029
,
ENST00000269280
,
ENST00000354411
,
ENSP00000346390
,
ENST00000544378
,
ENST00000571451
,
ENSP00000269280
,
ENSP00000460216
,
ENST00000572272
,
ENSP00000262467
,
ENST00000577119
,
ENSP00000460475
,
ENST00000617618
,
ENST00000262467
,
ENSP00000459661
,
ENSG00000091592
PRO
Q9C000
Pharos - Targets
Q9C000
Orphanet
16871
HMDB Protein
HMDBP13952
PDB
6X6C
,
1PN5
,
6K7V
,
6XKK
,
4IM6
,
5Y3S
,
4IFP
,
3KAT
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.746
13
UniProt:P29466 CASP1
5
CASP1(1-119) [cytosol]
(R-HSA-448680)
CASP1(120-297) [cytosol]
(R-HSA-448686)
CASP1(317-404) [cytosol]
(R-HSA-448704)
CASP1(298-316) [cytosol]
(R-HSA-448674)
CASP1(1-404) [cytosol]
(R-HSA-448692)
0.656
3
UniProt:Q07817 BCL2L1
2
BCL2L1 [cytosol]
(R-HSA-50771)
BCL2L1 [mitochondrial outer membrane]
(R-HSA-114236)
0.646
9
UniProt:Q9ULZ3 PYCARD
4
PYCARD [cytosol]
(R-HSA-561191)
PYCARD [secretory granule lumen]
(R-HSA-6800957)
PYCARD [extracellular region]
(R-HSA-6806196)
PYCARD [azurophil granule lumen]
(R-HSA-6798768)
0.558
5
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