Reactome | IL1A(1-271) [cytosol]

IL1A(1-271) [cytosol]

Stable Identifier

R-HSA-449042

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IL1A propeptide, Interleukin-1 alpha propeptide, IL1A, IL1A_HUMAN

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Cell recruitment (pro-inflammatory response) (Homo sapiens)
        
        Purinergic signaling in leishmaniasis infection (Homo sapiens)
        
        Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)
        
        Interleukin-1 family propeptides [cytosol] (Homo sapiens)
        
        IL1A(1-271) [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01583 IL1A

Gene Names

IL1A, IL1F1

Chain

propeptide:1-112, chain:113-271

Reference Genes

BioGPS Gene:3552 IL1A

COSMIC (genes):IL1A IL1A

CTD Gene:3552 IL1A

dbSNP Gene:3552 IL1A

ENSEMBL:ENSG00000115008 IL1A

HGNC:5991 IL1A

KEGG:hsa:3552 IL1A

Monarch:3552 IL1A

NCBI Gene:3552 IL1A

OMIM:147760 IL1A

UCSC:P01583 IL1A

Reference Transcript

RefSeq:NM_000575.4 IL1A

Other Identifiers

11725198_at

16901974

210118_PM_s_at

210118_s_at

2571484

2571485

2571486

2571487

2571488

2571489

2571491

2571492

2571493

2571494

2571496

3552

8054712

A_23_P72096

GE563350

GO:0001660

GO:0001666

GO:0001819

GO:0002248

GO:0002376

GO:0005125

GO:0005149

GO:0005507

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0006355

GO:0006883

GO:0006915

GO:0006954

GO:0006955

GO:0007283

GO:0007507

GO:0008285

GO:0009986

GO:0010193

GO:0010332

GO:0010575

GO:0010628

GO:0010893

GO:0012501

GO:0014070

GO:0019221

GO:0022414

GO:0031424

GO:0032308

GO:0032496

GO:0032743

GO:0032755

GO:0032760

GO:0032874

GO:0032956

GO:0033092

GO:0033591

GO:0034605

GO:0035234

GO:0043123

GO:0043226

GO:0045766

GO:0045840

GO:0045944

GO:0046330

GO:0046688

GO:0048018

GO:0048856

GO:0050714

GO:0051781

GO:0070374

GO:0071222

GO:0097192

GO:0098772

GO:1902624

GO:1904445

GO:2001240

HMNXSV003036315

ILMN_1658483

PH_hs_0000235

TC02002218.hg

g186277_3p_a_at

Participates

as a candidate of

Interleukin-1 family propeptides [cytosol] (Homo sapiens)

Other forms of this molecule

Myr82K-Myr83K-IL1A [extracellular region]

IL1A(1-112) [cytosol]

2xMyri-IL1A [cytosol]

Inferred To

il1fma [cytosol] (Danio rerio)

Il1a [cytosol] (Mus musculus)

Il1a [cytosol] (Rattus norvegicus)

il1b [cytosol] (Xenopus tropicalis)

Homologues of IL1A(1-271) [cytosol] (Xenopus tropicalis)

IL1A [cytosol] (Bos taurus)

IL1A [cytosol] (Canis familiaris)

IL1A [cytosol] (Sus scrofa)

LOC105946938 [cytosol] (Xenopus tropicalis)

il-1beta [cytosol] (Gallus gallus)

Cross References

RefSeq

NP_000566.3

ENSEMBL

ENSP00000263339, ENST00000263339

OpenTargets

ENSG00000115008

HPA

ENSG00000115008-IL1A

PRO

P01583

Pharos - Targets

P01583

GlyGen

P01583

PDB

2L5X, 2ILA, 5UC6, 2KKI

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27930 IL1R2	1	IL1R2 [plasma membrane] (R-HSA-197598)	0.661	4
UniProt:O00165 HAX1			0.621	3
UniProt:P50222 MEOX2			0.556	3
UniProt:O60684 KPNA6	2	KPNA6 [nucleoplasm] (R-HSA-9734665) KPNA6 [cytosol] (R-HSA-9734672)	0.556	3
UniProt:P29466 CASP1	5	CASP1(1-119) [cytosol] (R-HSA-448680) CASP1(120-297) [cytosol] (R-HSA-448686) CASP1(317-404) [cytosol] (R-HSA-448704) CASP1(298-316) [cytosol] (R-HSA-448674) CASP1(1-404) [cytosol] (R-HSA-448692)	0.524	3