Reactome | GGC-RAB6A [trans-Golgi network membrane]

GGC-RAB6A [trans-Golgi network membrane]

Stable Identifier

R-HSA-8876079

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

trans-Golgi network membrane

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P20340 RAB6A

Gene Names

RAB6A, RAB6

Chain

initiator methionine:1, chain:2-208

Reference Genes

BioGPS Gene:5870 RAB6A

COSMIC (genes):RAB6A RAB6A

CTD Gene:5870 RAB6A

dbSNP Gene:5870 RAB6A

ENSEMBL:ENSG00000175582 RAB6A

HGNC:9786 RAB6A

KEGG:hsa:5870 RAB6A

Monarch:5870 RAB6A

NCBI Gene:5870 RAB6A

OMIM:179513 RAB6A

UCSC:P20340 RAB6A

Reference Transcript

Participates

as a member of

GGC-RAB6 [trans-Golgi network membrane] (Homo sapiens)

Other forms of this molecule

RAB6A [Golgi membrane]

RAB6A [secretory granule membrane]

RAB6A [plasma membrane]

RAB6A [cytosol]

GGC-RAB6A [cytosol]

RAB6A [trans-Golgi network membrane]

RAB6A [endoplasmic reticulum membrane]

Inferred To

ryh1 [trans-Golgi network membrane] (Schizosaccharomyces pombe)

Homologues of GGC-RAB6A [trans-Golgi network membrane] (Caenorhabditis elegans)

Rab6 [trans-Golgi network membrane] (Drosophila melanogaster)

YPT6 [trans-Golgi network membrane] (Saccharomyces cerevisiae)

Rab6a [trans-Golgi network membrane] (Mus musculus)

Rab6a [trans-Golgi network membrane] (Rattus norvegicus)

rab-6.2 [trans-Golgi network membrane] (Caenorhabditis elegans)

rab-6.1 [trans-Golgi network membrane] (Caenorhabditis elegans)

GGC-RAB6A [trans-Golgi network membrane] (Plasmodium falciparum)

rab6 [trans-Golgi network membrane] (Dictyostelium discoideum)

RAB6A [trans-Golgi network membrane] (Bos taurus)

RAB6A [trans-Golgi network membrane] (Gallus gallus)

Modified Residues

Name

S-geranylgeranyl-L-cysteine at 206

Coordinate

206

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Name

S-geranylgeranyl-L-cysteine at 208

Coordinate

208

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Cross References

RefSeq

NP_001230648.1, NP_001230647.1, NP_942599.1, NP_002860.2

OpenTargets

ENSG00000175582

ENSEMBL

ENST00000310653, ENSP00000336850, ENSP00000445350, ENST00000336083, ENST00000541588, ENSP00000443782, ENST00000541973, ENSP00000311449, ENSG00000175582

HPA

ENSG00000175582-RAB6A

GeneCards

RAB6A

PRO

P20340

Pharos - Targets

P20340

GlyGen

P20340

PDB

3BBP, 4DKX, 5LEF, 2GIL, 1YZQ, 3CWZ

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q01968 OCRL	4	OCRL [Golgi membrane] (R-HSA-434339) OCRL [cytoplasmic vesicle membrane] (R-HSA-434214) OCRL [plasma membrane] (R-HSA-3769049) OCRL [cytosol] (R-HSA-1806196)	0.875	14
UniProt:Q92871 PMM1	1	PMM1 [cytosol] (R-HSA-532541)	0.666	4
UniProt:Q8IWJ2 GCC2	3	GCC2 [cytosol] (R-HSA-6813880) GCC2(1-1204)-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9713455) GCC2(1-1204)-ALK(1059-1620) fusion [cytosol] (R-HSA-9713458)	0.618	4
UniProt:Q4ADV7 RIC1	2	RIC1 [trans-Golgi network membrane] (R-HSA-6810989) RIC1 [cytosol] (R-HSA-8847845)	0.591	3
UniProt:Q92546 RGP1	2	RGP1 [trans-Golgi network membrane] (R-HSA-6810986) RGP1 [cytosol] (R-HSA-8847842)	0.577	3
UniProt:Q9UP95 SLC12A4	1	SLC12A4 [plasma membrane] (R-HSA-426167)	0.527	2
UniProt:Q01968-2 OCRL			0.527	2
UniProt:Q9NRW1 RAB6B	6	RAB6B [endoplasmic reticulum membrane] (R-HSA-8849252) RAB6B [trans-Golgi network membrane] (R-HSA-6810985) RAB6B [Golgi membrane] (R-HSA-8849249) GGC-RAB6B [trans-Golgi network membrane] (R-HSA-8876081) GGC-RAB6B [cytosol] (R-HSA-8874055) RAB6B [cytosol] (R-HSA-6810983)	0.527	3
UniProt:P31150 GDI1	1	GDI1 [cytosol] (R-HSA-195106)	0.527	3
UniProt:Q8TD16 BICD2	1	BICD2 [cytosol] (R-HSA-8848107)	0.463	3
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE			0.462	2

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