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CALCA(83-119) [extracellular region]
Stable Identifier
R-HSA-419781
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Calcitonin, CALCA, CALC_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
Amyloid fibrils have additional components (Homo sapiens)
Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Calcitonin amyloid fibril [extracellular region] (Homo sapiens)
CALCA(83-119) [extracellular region] (Homo sapiens)
Amyloid fibrils [plasma membrane] (Homo sapiens)
Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Calcitonin amyloid fibril [extracellular region] (Homo sapiens)
CALCA(83-119) [extracellular region] (Homo sapiens)
Amyloid precursor proteins form ordered fibrils (Homo sapiens)
Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Calcitonin amyloid fibril [extracellular region] (Homo sapiens)
CALCA(83-119) [extracellular region] (Homo sapiens)
Amyloid fibril monomers [extracellular region] (Homo sapiens)
Localized amyloid fibril monomers [extracellular region] (Homo sapiens)
CALCA(83-119) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
CALCR:CALCA(83-119) [plasma membrane] (Homo sapiens)
CALCA(83-119) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
CALCR:CALCA(83-119) [plasma membrane] (Homo sapiens)
CALCA(83-119) [extracellular region] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
CALCR:CALCA(83-119) [plasma membrane] (Homo sapiens)
CALCA(83-119) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
CALCR:CALCA(83-119) [plasma membrane] (Homo sapiens)
CALCA(83-119) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
CALCR:CALCA(83-119) [plasma membrane] (Homo sapiens)
CALCA(83-119) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
CALCA(83-119) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class B/2 (Secretin family receptors) (Homo sapiens)
Calcitonin-like ligand receptors (Homo sapiens)
CALCA(83-119) binds CALCA antibodies (Homo sapiens)
CALCA(83-119) [extracellular region] (Homo sapiens)
CALCA(83-119):CALCA antibodies [extracellular region] (Homo sapiens)
CALCA(83-119) [extracellular region] (Homo sapiens)
CALCA(83-119) binds CALCR (Homo sapiens)
CALCA(83-119) [extracellular region] (Homo sapiens)
CALCR:CALCA(83-119) [plasma membrane] (Homo sapiens)
CALCA(83-119) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01258 CALCA
Gene Names
CALCA, CALC1
Chain
signal peptide:1-25, propeptide:26-82, peptide:85-116, peptide:121-141
Reference Genes
BioGPS Gene:796 CALCA
COSMIC (genes):CALCA CALCA
CTD Gene:796 CALCA
dbSNP Gene:796 CALCA
ENSEMBL:ENSG00000110680 CALCA
HGNC:1437 CALCA
KEGG:hsa:796 CALCA
Monarch:796 CALCA
NCBI Gene:796 CALCA
OMIM:114130 CALCA
UCSC:P01258 CALCA
Reference Transcript
RefSeq:NM_001741.2 CALCA
RefSeq:XM_017018283.1 CALCA
RefSeq:XM_017018284.1 CALCA
RefSeq:NM_001033952.2 CALCA
Other Identifiers
11730413_a_at
11730414_a_at
11730415_s_at
16736092
210727_PM_at
210727_at
210728_PM_s_at
210728_s_at
217495_3p_x_at
217495_PM_x_at
217495_x_at
217561_PM_at
217561_at
3321644
3364128
3364129
3364130
3364131
3364132
3364133
3364134
3364137
3364138
3364139
36299_at
36300_at
7946749
796
A_23_P301846
A_24_P198178
A_33_P3318771
GE59640
GO:0001503
GO:0001935
GO:0001944
GO:0001976
GO:0001984
GO:0002031
GO:0002376
GO:0002548
GO:0003012
GO:0003013
GO:0005102
GO:0005179
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0006355
GO:0006468
GO:0006874
GO:0006939
GO:0006954
GO:0007155
GO:0007159
GO:0007165
GO:0007189
GO:0007190
GO:0007200
GO:0007204
GO:0007218
GO:0007267
GO:0007566
GO:0007631
GO:0008217
GO:0009408
GO:0010523
GO:0016192
GO:0022414
GO:0023052
GO:0030279
GO:0030424
GO:0031410
GO:0031623
GO:0031716
GO:0032147
GO:0032730
GO:0032757
GO:0042311
GO:0042802
GO:0043005
GO:0043025
GO:0043195
GO:0043226
GO:0043542
GO:0044877
GO:0045651
GO:0045671
GO:0045776
GO:0045779
GO:0045892
GO:0045986
GO:0048018
GO:0048265
GO:0048856
GO:0048870
GO:0050877
GO:0050965
GO:0051480
GO:0071356
GO:0098686
GO:0098772
GO:0098992
GO:1990090
GO:1990408
HMNXSV003025904
Hs.288190.0.A1_3p_at
Hs.37058.2.S1_3p_a_at
Hs.37058.2.S1_3p_s_at
Hs.37058.2.S1_3p_x_at
ILMN_1702566
ILMN_1807034
ILMN_2327244
PH_hs_0002935
TC11001445.hg
TC11003065.hg
X15943_at
g177965_3p_at
Participates
as a component of
CALCA(83-119):CALCA antibodies [extracellular region] (Homo sapiens)
CALCR:CALCA(83-119) [plasma membrane] (Homo sapiens)
as an input of
CALCA(83-119) binds CALCA antibodies (Homo sapiens)
CALCA(83-119) binds CALCR (Homo sapiens)
as a member of
Localized amyloid fibril monomers [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
as a repeated unit of
Calcitonin amyloid fibril [extracellular region] (Homo sapiens)
Inferred To
calca [extracellular region]
(Danio rerio)
calca [extracellular region]
(Xenopus tropicalis)
CRSP-3 [extracellular region]
(Canis familiaris)
CALCA(83-119) [extracellular region]
(Gallus gallus)
CT [extracellular region]
(Bos taurus)
CALCB [extracellular region]
(Sus scrofa)
Calca [extracellular region]
(Mus musculus)
Calca [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_001029124.1
,
XP_016873772.1
,
XP_016873773.1
,
NP_001732.1
ENSEMBL
ENSP00000331746
,
ENSP00000379657
,
ENST00000331587
,
ENST00000469608
,
ENST00000396372
,
ENSP00000420618
OpenTargets
ENSG00000110680
PRO
P01258
Pharos - Targets
P01258
GlyGen
P01258
HMDB Protein
HMDBP07530
PDB
7TYH
,
7TYO
,
2JXZ
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01258 CALCA
1
CALCA(83-119) [extracellular region]
(R-HSA-419781)
0.598
3
UniProt:X5D778 X5D778
0.556
3
UniProt:Q01814 ATP2B2
1
ATP2B2 [plasma membrane]
(R-HSA-418303)
0.499
2
UniProt:P23634 ATP2B4
1
ATP2B4 [plasma membrane]
(R-HSA-418304)
0.499
2
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