ATP2B4 binds to NOS1, inhibiting it

Stable Identifier
R-HSA-5617178
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Plasma membrane calcium-transporting ATPase 4 (ATP2B4 aka PMCA4) binds and inhibits cardiac neuronal nitric-oxide synthase (NOS1 aka nNOS, a powerful regulator of the beta-adrenergic contractile response in the heart) by changing local calcium concentration (Duan et al. 2013). Reduced nNOS activity leads to a reduction in cGMP which in turn results in the reduction of phosphodiesterase (PDE) activity. As a result, cAMP degradation is prevented, increasing protein kinase A (PKA) activity, which can lead to increased phosphorylation of proteins involved in the excitation-contraction coupling process such as cardiac phospholamban (PLN aka PLB) and of cardiac muscle troponin I (TNNI3 aka cTnI) (Mohamed et al. 2009).

Literature References
PubMed ID Title Journal Year
23549614 Plasma membrane calcium ATPase 4b inhibits nitric oxide generation through calcium-induced dynamic interaction with neuronal nitric oxide synthase

Duan, W, Zhou, J, Li, W, Zhou, T, Chen, Q, Yang, F, Wei, T

Protein Cell 2013
19278978 Specific role of neuronal nitric-oxide synthase when tethered to the plasma membrane calcium pump in regulating the beta-adrenergic signal in the myocardium

Mohamed, TM, Oceandy, D, Prehar, S, Alatwi, N, Hegab, Z, Baudoin, FM, Pickard, A, Zaki, AO, Nadif, R, Cartwright, EJ, Neyses, L

J. Biol. Chem. 2009
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!