Reactome | LGALS3 [secretory granule membrane]

LGALS3 [secretory granule membrane]

Stable Identifier

R-HSA-6803327

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule membrane

Synonyms

Galectin-3, LEG3_HUMAN, AGER-3

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P17931 LGALS3

Gene Names

LGALS3, Galectin-3, MAC2

Chain

initiator methionine:, chain:2-250

Reference Genes

BioGPS Gene:3958 LGALS3

COSMIC (genes):LGALS3 LGALS3

CTD Gene:3958 LGALS3

dbSNP Gene:3958 LGALS3

ENSEMBL:ENSG00000131981 LGALS3

ENSEMBL_homo_sapiens_GENE:ENSG00000131981.16 LGALS3

HGNC:6563 LGALS3

KEGG Gene (Homo sapiens):3958 LGALS3

Monarch:3958 LGALS3

NCBI Gene:3958 LGALS3

OMIM:153619 LGALS3

UCSC:P17931 LGALS3

Reference Transcript

RefSeq:NM_002306.3 LGALS3

Other Identifiers

11725937_a_at

16784381

208949_PM_s_at

208949_s_at

3536710

3536730

3536731

3536732

3536733

3536738

3536743

3536744

3536745

35367_at

3958

7974461

A_23_P128919

A_33_P3306163

GE60548

GO:0001772

GO:0002376

GO:0002548

GO:0003723

GO:0004864

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005681

GO:0005737

GO:0005739

GO:0005743

GO:0005829

GO:0005886

GO:0006397

GO:0007155

GO:0008380

GO:0009986

GO:0012501

GO:0016020

GO:0016071

GO:0016192

GO:0019863

GO:0019903

GO:0023052

GO:0030154

GO:0030246

GO:0030312

GO:0030593

GO:0030667

GO:0030855

GO:0031012

GO:0031334

GO:0031410

GO:0036211

GO:0042056

GO:0042129

GO:0043226

GO:0043236

GO:0045087

GO:0045806

GO:0048018

GO:0048245

GO:0048246

GO:0048856

GO:0048870

GO:0050860

GO:0050918

GO:0060090

GO:0062023

GO:0065003

GO:0070062

GO:0070232

GO:0071674

GO:0071677

GO:0072659

GO:0090280

GO:0098542

GO:0098772

GO:0101003

GO:0140693

GO:1902041

GO:1903078

GO:1903614

GO:2000521

GO:2001189

GO:2001237

HMNXSV003045087

HMNXSV003056424

ILMN_1803788

M57710_at

PH_hs_0030094

TC14000323.hg

TC14001693.hg

g12654570_3p_s_at

Participates

as a member of

Secretory granule membrane proteins [secretory granule membrane] (Homo sapiens)

Other forms of this molecule

LGALS3 [ficolin-1-rich granule membrane]

LGALS3 [plasma membrane]

Inferred To

lec-4 [secretory granule membrane] (Caenorhabditis elegans)

lec-11 [secretory granule membrane] (Caenorhabditis elegans)

lec-2 [secretory granule membrane] (Caenorhabditis elegans)

Dmel\CG13950 [secretory granule membrane] (Drosophila melanogaster)

lec-7 [secretory granule membrane] (Caenorhabditis elegans)

LGALS3 [secretory granule membrane] (Bos taurus)

LGALS3 [secretory granule membrane] (Caenorhabditis elegans)

LGALS3 [secretory granule membrane] (Canis familiaris)

LGALS3 [secretory granule membrane] (Gallus gallus)

LGALS3 [secretory granule membrane] (Mus musculus)

LGALS3 [secretory granule membrane] (Rattus norvegicus)

LGALS3 [secretory granule membrane] (Sus scrofa)

lec-6 [secretory granule membrane] (Caenorhabditis elegans)

lec-9 [secretory granule membrane] (Caenorhabditis elegans)

Homologues of LGALS3 [secretory granule membrane] (Caenorhabditis elegans)

Homologues of LGALS3 [secretory granule membrane] (Canis familiaris)

lgals3b [secretory granule membrane] (Danio rerio)

lec-10 [secretory granule membrane] (Caenorhabditis elegans)

lec-5 [secretory granule membrane] (Caenorhabditis elegans)

lec-8 [secretory granule membrane] (Caenorhabditis elegans)

lgals3 [secretory granule membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_002297.2

OpenTargets

ENSG00000131981

HPA

ENSG00000131981-LGALS3

GeneCards

P17931

ZINC - Substances

LEG3_HUMAN

Ensembl

ENSP00000254301, ENST00000254301, ENSG00000131981

ZINC target

P17931

PRO

P17931

Pharos - Targets

P17931

ZINC - Predictions - Purchasable

LEG3_HUMAN

PDB

6EOL, 8PF9, 6Y4C, 6B8K, 4BM8, 3ZSM, 6KXB, 6Q0Q, 6Q17, 6ZVF, 4LBJ, 4BLI, 8PFF, 3ZSK, 6F6Y, 8OJO, 8OJM, 6RZH, 8BZ3, 3AYE, 8OJI, 7RDP, 6RZG, 1KJR, 5NFC, 3T1L, 4LBL, 6FOF, 6RZJ, 8OJK, 4LBN, 6RZI, 6F2Q, 6KXA, 5NF7, 4R9B, 5E8A, 6FK2, 2NMO, 4R9D, 7RDO, 5NFA, 3AYC, 6QGE, 6RZF, 6I76, 6I78, 6EXY, 5E88, 5H9R, 6RZK, 7XFA, 6RHM, 6I74, 8PBF, 6RZL, 5OAX, 6QGF, 8ITZ, 7DF5, 6RHL, 7ZQX, 2XG3, 3ZSL, 8ITX, 6EOG, 4RL7, 6Y78, 1A3K, 5ODY, 4XBN, 6RZM, 4BLJ, 6TF6, 6TF7, 3ZSJ, 5IUQ, 6G0V, 4JC1, 6QLT, 4LBK, 5NFB, 2NN8, 6QLS, 7CXA, 4LBM, 3T1M, 1KJL, 4LBO, 6QLU, 6QLQ, 7RGZ, 4R9A, 7RH1, 6QLP, 5NF9, 7RGY, 2NMN, 6QLR, 3AYA, 7RH4, 4R9C, 6H64, 6EYM, 3AYD, 7RH3, 6I77, 8PPN, 7BE3, 5EXO, 5H9P, 7RH0, 6QLO, 5E89, 6QLN, 7RGX, 4JCK, 6I75

Interactors (63)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13740 ALCAM	1	ALCAM [plasma membrane] (R-HSA-197750)	0.667	6
UniProt:Q9NZ81 PRR13			0.666	4
UniProt:Q8N697 SLC15A4	4	SLC15A4 [plasma membrane] (R-HSA-6800447) SLC15A4 [specific granule membrane] (R-HSA-6799715) SLC15A4 [endolysosome membrane] (R-HSA-9860282) SLC15A4 [lysosomal membrane] (R-HSA-428039)	0.643	5
UniProt:P17813 EGLN			0.626	5
UniProt:Q9HBW0 LPAR2	1	LPAR2 [plasma membrane] (R-HSA-419393)	0.623	3
UniProt:O14931-2 NCR3			0.602	3
UniProt:Q6ZP80 TM182			0.564	2
UniProt:P30203 CD6			0.558	2
UniProt:O75177 SS18L1	1	SS18L1 [nucleoplasm] (R-HSA-9727481)	0.556	3
UniProt:Q13427 PPIG	2	PPIG [cytosol] (R-HSA-9728768) PPIG [nucleoplasm] (R-HSA-9769592)	0.556	3
UniProt:O43186 CRX			0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q96L93-6 KIF16B			0.556	3
UniProt:P17931 LGALS3	3	LGALS3 [ficolin-1-rich granule membrane] (R-HSA-6803307) LGALS3 [secretory granule membrane] (R-HSA-6803327) LGALS3 [plasma membrane] (R-HSA-879445)	0.553	2
UniProt:P12763	5	AHSG [platelet alpha granule lumen] (R-BTA-8848910) AHSG [extracellular region] (R-BTA-6804820) AHSG [secretory granule lumen] (R-BTA-6804806) phospho-AHSG [endoplasmic reticulum lumen] (R-BTA-8957019) AHSG [endoplasmic reticulum lumen] (R-BTA-8956762)	0.544	2
UniProt:Q9H8X2 IPPK	2	IPPK [cytosol] (R-HSA-1604598) IPPK [nucleoplasm] (R-HSA-2023949)	0.527	2
UniProt:Q9UF02 CCG5			0.527	2
UniProt:O60636 TSN2			0.527	3
UniProt:Q9Y6M5 SLC30A1	1	SLC30A1 [plasma membrane] (R-HSA-435361)	0.527	3
UniProt:Q9Y6M7 SLC4A7	1	SLC4A7 [plasma membrane] (R-HSA-425552)	0.527	4
UniProt:P08183 ABCB1	1	ABCB1 [plasma membrane] (R-HSA-1457534)	0.527	3
UniProt:Q6UVK1 CSPG4	20	CSPG4 [plasma membrane] (R-HSA-9734933) dermatan-CSPG4 [Golgi lumen] (R-HSA-5607523) D2,4(S)2-CSPG4 [Golgi lumen] (R-HSA-2065081) D2,4,4(S)3-CSPG4 [Golgi lumen] (R-HSA-2065076) D4S-CSPG4 [Golgi lumen] (R-HSA-2065097) CSE-CSPG4 [lysosomal lumen] (R-HSA-2065147) C6S-CSPG4 [lysosomal lumen] (R-HSA-2065065) C4S-CSPG4 [lysosomal lumen] (R-HSA-2065064) D2,4(S)2-CSPG4 [lysosomal lumen] (R-HSA-2065247) D4S-CSPG4 [lysosomal lumen] (R-HSA-2065256) D4S-CSPG4 [extracellular region] (R-HSA-2065222) D2,4(S)2-CSPG4 [extracellular region] (R-HSA-2065203) D2,4,4(S)3-CSPG4 [extracellular region] (R-HSA-2065092) CSPG4 [lysosomal lumen] (R-HSA-2065223) D2,4,4(S)3-CSPG4 [lysosomal lumen] (R-HSA-2065062) CSE-CSPG4 [extracellular region] (R-HSA-2064110) C6S-CSPG4 [extracellular region] (R-HSA-2064251) C4S-CSPG4 [extracellular region] (R-HSA-2064211) CSE-CSPG4 [Golgi lumen] (R-HSA-2064166) Gal-Gal-Xyl-CSPG4 [Golgi lumen] (R-HSA-2064062)	0.527	4
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.527	2
UniProt:P07384 CAPN1	4	CAPN1 [plasma membrane] (R-HSA-3828038) CAPN1 [cytosol] (R-HSA-3288367) CAPN1 [extracellular region] (R-HSA-6806485) CAPN1 [ficolin-1-rich granule lumen] (R-HSA-6801284)	0.527	3
UniProt:Q9H6Y7 RN167			0.527	3
UniProt:O60503 ADCY9	1	ADCY9 [plasma membrane] (R-HSA-379055)	0.527	3
UniProt:Q5KU26 COLEC12	2	COLEC12 [endocytic vesicle membrane] (R-HSA-2981044) COLEC12 [plasma membrane] (R-HSA-2187209)	0.527	3
UniProt:O94886 TMEM63A	3	TMEM63A [specific granule membrane] (R-HSA-6799721) TMEM63A [plasma membrane] (R-HSA-6800445) TMEM63A [tertiary granule membrane] (R-HSA-6800945)	0.527	2
UniProt:P25391 LAMA1	1	LAMA1 [extracellular region] (R-HSA-215953)	0.527	3
UniProt:Q9H7F0 AT133			0.527	4
UniProt:Q9HC97 GPR35	1	GPR35 [plasma membrane] (R-HSA-3295332)	0.527	2
UniProt:P28335 HTR2C	1	HTR2C [plasma membrane] (R-HSA-390965)	0.527	2
UniProt:P50443 SLC26A2	5	SLC26A2 R178* [plasma membrane] (R-HSA-3621784) SLC26A2 G255E [plasma membrane] (R-HSA-3560798) SLC26A2 L483P [plasma membrane] (R-HSA-3560803) SLC26A2 N425D [plasma membrane] (R-HSA-3621698) SLC26A2 [plasma membrane] (R-HSA-427669)	0.527	4
UniProt:Q9ULI3 HEG1			0.527	4
UniProt:O60266 ADCY3	1	ADCY3 [plasma membrane] (R-HSA-379051)	0.527	4
UniProt:Q8N468 MFD4A			0.527	3
UniProt:Q86WC4 OSTM1	1	OSTM1 [lysosomal membrane] (R-HSA-2730944)	0.527	2
UniProt:Q9P2B2 FPRP			0.527	4
UniProt:Q9HB90 RRAGC	1	RRAGC [cytosol] (R-HSA-5653949)	0.527	4
UniProt:Q92581 SLC9A6	6	SLC9A6 E255_S256del [early endosome membrane] (R-HSA-5661066) SLC9A6 E547* [early endosome membrane] (R-HSA-5661037) SLC9A6 R468* [early endosome membrane] (R-HSA-5661072) SLC9A6 338-340del [early endosome membrane] (R-HSA-5661042) SLC9A6 H171fs*60 [early endosome membrane] (R-HSA-5661079) SLC9A6 [early endosome membrane] (R-HSA-425984)	0.527	4
UniProt:Q9Y666 SLC12A7	1	SLC12A7 [plasma membrane] (R-HSA-426164)	0.527	4
UniProt:P07942 LAMB1	3	p-LAMB1 [endoplasmic reticulum lumen] (R-HSA-8956889) LAMB1 [endoplasmic reticulum lumen] (R-HSA-8956706) LAMB1 [extracellular region] (R-HSA-215959)	0.527	3
UniProt:P56199 ITGA1	1	ITGA1 [plasma membrane] (R-HSA-215939)	0.527	3
UniProt:Q6PCB8 EMB	1	EMB [plasma membrane] (R-HSA-8856535)	0.527	3
UniProt:P55082 MFAP3	1	MFAP3 [extracellular region] (R-HSA-2161382)	0.527	3
UniProt:P17301 ITGA2	1	ITGA2 [plasma membrane] (R-HSA-57562)	0.527	3
UniProt:Q9UKA2 FBXL4	1	FBXL4 [cytosol] (R-HSA-8850899)	0.527	2
UniProt:Q86UN3 RTN4RL2	2	cleaved GPI-RTN4RL2 [extracellular region] (R-HSA-8941146) GPI-RTN4RL2 [plasma membrane] (R-HSA-8940807)	0.527	3
UniProt:Q6DKI2 LEG9C			0.527	2
UniProt:Q9NRX5 SERINC1	1	SERINC1 [plasma membrane] (R-HSA-5215963)	0.527	2
UniProt:Q12913 PTPRJ	2	PTPRJ [plasma membrane] (R-HSA-6785269) PTPRJ [specific granule membrane] (R-HSA-6799570)	0.527	4
UniProt:Q9Y6X5 ENPP4	2	ENPP4 [plasma membrane] (R-HSA-6806519) ENPP4 [ficolin-1-rich granule membrane] (R-HSA-6801493)	0.527	3
UniProt:Q9Y2T5 GPR52			0.527	3
UniProt:P08962 CD63	3	CD63 [platelet dense granule membrane] (R-HSA-51683) CD63 [plasma membrane] (R-HSA-114583) CD63 [azurophil granule membrane] (R-HSA-6799157)	0.527	3
UniProt:Q9UBG0 MRC2	3	MRC2 [plasma membrane] (R-HSA-1216516) MRC2 [clathrin-coated endocytic vesicle membrane] (R-HSA-1236893) MRC2 [early endosome membrane] (R-HSA-1236847)	0.527	3
UniProt:Q9Y2T6 GPR55	1	GPR55 [plasma membrane] (R-HSA-444504)	0.527	2
UniProt:P51790 CLCN3	1	CLCN3 [late endosome membrane] (R-HSA-2671918)	0.527	3
UniProt:Q9Y324 FCF1	1	FCF1 [nucleoplasm] (R-HSA-6790672)	0.527	2
UniProt:P36222 CHI3L1	2	CHI3L1 [extracellular region] (R-HSA-6806319) CHI3L1 [specific granule lumen] (R-HSA-6799507)	0.524	2
UniProt:Q29983 MICA	1	MICA [plasma membrane] (R-HSA-5696432)	0.524	2
UniProt:Q14627 IL13RA2	1	IL13RA2 [extracellular region] (R-HSA-449666)	0.499	2
UniProt:P09237 MMP7	6	MMP7(18-94) [extracellular region] (R-HSA-1604729) MMP7(51-94) [extracellular region] (R-HSA-1604760) MMP7(95-267) [extracellular region] (R-HSA-1442479) MMP7(18-50) [extracellular region] (R-HSA-1604759) MMP7(18-267) [extracellular region] (R-HSA-1604734) MMP7(51-267) [extracellular region] (R-HSA-1604766)	0.489	5

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