Reactome | PTGIR [plasma membrane]

PTGIR [plasma membrane]

Stable Identifier

R-HSA-391834

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

IP receptor, RecName: Full=Prostacyclin receptor; AltName: Full=Prostanoid IP receptor; AltName: Full=PGI receptor; AltName: Full=Prostaglandin I2 receptor;
GN Name=PTGIR; Synonyms=PRIPR;
OS Homo sapiens, PI2R_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P43119 PTGIR

Gene Names

PTGIR, PRIPR

Chain

chain:1-383, propeptide:384-386

Reference Genes

BioGPS Gene:5739 PTGIR

COSMIC (genes):PTGIR PTGIR

CTD Gene:5739 PTGIR

dbSNP Gene:5739 PTGIR

ENSEMBL:ENSG00000160013 PTGIR

HGNC:9602 PTGIR

KEGG:hsa:5739 PTGIR

Monarch:5739 PTGIR

NCBI Gene:5739 PTGIR

OMIM:600022 PTGIR

UCSC:P43119 PTGIR

Reference Transcript

RefSeq:NM_000960.4 PTGIR

Other Identifiers

11726062_at

11758292_s_at

1555620_3p_a_at

1555620_PM_a_at

1555620_a_at

16873562

206187_PM_at

206187_at

3866095

3866096

3866097

3866098

3866099

3866100

3866101

3866102

3866103

3866104

5739

758_at

8037775

A_23_P340848

A_24_P322426

D38128_at

GE901484

GO:0004930

GO:0005085

GO:0005829

GO:0005886

GO:0006954

GO:0007186

GO:0007187

GO:0007189

GO:0007204

GO:0007267

GO:0010642

GO:0016020

GO:0016501

GO:0023052

GO:0032496

GO:0048662

GO:0060089

GO:0098772

HMNXSV003009353

Hs2.393.2.S1_3p_at

Hs2.393.2.S1_3p_s_at

ILMN_1747023

PH_hs_0026352

TC19001650.hg

g4506262_3p_at

Participates

as a component of

as an input of

as an output of

Dissociation of the Prostacyclin receptor:Gs complex (Homo sapiens)

as a member of

GPCRs that activate Gs [plasma membrane] (Homo sapiens)

Inferred To

Ptgir [plasma membrane] (Mus musculus)

Ptgir [plasma membrane] (Rattus norvegicus)

BcDNA:GH27361 [plasma membrane] (Drosophila melanogaster)

PTGIR [plasma membrane] (Bos taurus)

PTGIR [plasma membrane] (Canis familiaris)

PTGIR [plasma membrane] (Sus scrofa)

ptgir [plasma membrane] (Danio rerio)

ptgir [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_000951.1

ZINC - World Drugs

PI2R_HUMAN

Guide to Pharmacology - Targets

345

ENSEMBL

ENSG00000160013, ENSP00000291294, ENST00000291294

OpenTargets

ENSG00000160013

ZINC - FDA approved

PI2R_HUMAN

ZINC - Substances

PI2R_HUMAN

ZINC - Biogenic

PI2R_HUMAN

ZINC target

P43119

PRO

P43119

GlyGen

P43119

PDB

8X79, 8X7A

ZINC - Investigational

PI2R_HUMAN

ZINC - Metabolites

PI2R_HUMAN

HPA

ENSG00000160013-PTGIR

GeneCards

PTGIR

Pharos - Targets

P43119

ZINC - Predictions - Purchasable

PI2R_HUMAN

HMDB Protein

HMDBP02751

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7L8W6 DPH6	1	DPH6 [cytosol] (R-HSA-5358469)	0.527	2
UniProt:Q99808 SLC29A1	1	SLC29A1 [plasma membrane] (R-HSA-54335)	0.527	2
UniProt:Q16739 UGCG	1	UGCG [Golgi membrane] (R-HSA-1631585)	0.527	2
UniProt:O95427 PIGN	1	PIGN [endoplasmic reticulum membrane] (R-HSA-162724)	0.527	2
UniProt:Q9Y6M5 SLC30A1	1	SLC30A1 [plasma membrane] (R-HSA-435361)	0.527	2
UniProt:P24468 NR2F2	1	NR2F2 [nucleoplasm] (R-HSA-1183002)	0.527	2
UniProt:Q9H6D3 XKR8			0.527	2
UniProt:Q14332 FZD2	2	FZD2 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140723) FZD2 [plasma membrane] (R-HSA-443945)	0.527	2
UniProt:Q75V66 ANO5	1	ANO5 [plasma membrane] (R-HSA-2684890)	0.527	2
UniProt:Q5T3F8 CSCL2			0.527	2
UniProt:Q13563 PKD2	3	PKD2 [Golgi membrane] (R-HSA-5623393) PKD2 [Golgi-associated vesicle membrane] (R-HSA-5623411) PKD2 [ciliary membrane] (R-HSA-5623409)	0.527	2
UniProt:Q9H819 DJC18			0.527	2
UniProt:P48029 SLC6A8	1	SLC6A8 [plasma membrane] (R-HSA-200393)	0.527	2
UniProt:Q86Y56 DAAF5			0.527	2
UniProt:O94886 TMEM63A	3	TMEM63A [tertiary granule membrane] (R-HSA-6800945) TMEM63A [plasma membrane] (R-HSA-6800445) TMEM63A [specific granule membrane] (R-HSA-6799721)	0.527	2
UniProt:Q9P2E7 PCD10			0.527	2
UniProt:Q92990 GLMN	1	GLMN [cytosol] (R-HSA-8951779)	0.527	2
UniProt:P55082 MFAP3	1	MFAP3 [extracellular region] (R-HSA-2161382)	0.527	2
UniProt:P36383 GJC1	2	GJC1 [endoplasmic reticulum membrane] (R-HSA-190716) GJC1 [plasma membrane] (R-HSA-383285)	0.527	2
UniProt:Q8N697 SLC15A4	4	SLC15A4 [endolysosome membrane] (R-HSA-9860282) SLC15A4 [plasma membrane] (R-HSA-6800447) SLC15A4 [specific granule membrane] (R-HSA-6799715) SLC15A4 [lysosomal membrane] (R-HSA-428039)	0.527	2
UniProt:Q6NSJ5 LRRC8E	1	LRRC8E [plasma membrane] (R-HSA-8941539)	0.527	2
UniProt:Q9Y666 SLC12A7	1	SLC12A7 [plasma membrane] (R-HSA-426164)	0.527	2
UniProt:Q9BXP2 S12A9			0.527	2
UniProt:Q7Z7N9 TMEM179B	4	TMEM179B [ficolin-1-rich granule membrane] (R-HSA-6800989) TMEM179B [secretory granule membrane] (R-HSA-6801009) TMEM179B [plasma membrane] (R-HSA-6806263) TMEM179B [azurophil granule membrane] (R-HSA-6799362)	0.527	2
UniProt:Q8NHS3 MFSD8			0.527	2
UniProt:P19634 SLC9A1	1	SLC9A1 [plasma membrane] (R-HSA-426006)	0.527	2
UniProt:Q9UEW8 STK39			0.527	2
UniProt:Q9UBU6 FA8A1			0.527	2