Reactome | PTGIR [plasma membrane]

PTGIR [plasma membrane]

Stable Identifier

R-HSA-391834

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

IP receptor, RecName: Full=Prostacyclin receptor; AltName: Full=Prostanoid IP receptor; AltName: Full=PGI receptor; AltName: Full=Prostaglandin I2 receptor;
GN Name=PTGIR; Synonyms=PRIPR;
OS Homo sapiens, PI2R_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Leishmania infection (Homo sapiens)
    - Leishmania parasite growth and survival (Homo sapiens)
      - Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        PTGIR:PGI2 [plasma membrane] (Homo sapiens)
        
        PTGIR [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P43119 PTGIR

Gene Names

PTGIR, PRIPR

Chain

chain:1-383, propeptide:384-386

Reference Genes

BioGPS Gene:5739 PTGIR

COSMIC (genes):PTGIR PTGIR

CTD Gene:5739 PTGIR

dbSNP Gene:5739 PTGIR

ENSEMBL:ENSG00000160013 PTGIR

HGNC:9602 PTGIR

KEGG Gene (Homo sapiens):5739 PTGIR

Monarch:5739 PTGIR

NCBI Gene:5739 PTGIR

OMIM:600022 PTGIR

UCSC:P43119 PTGIR

Reference Transcript

RefSeq:NM_000960.3 PTGIR

Other Identifiers

0003710504

11726062_at

11758292_s_at

1555620_3p_a_at

1555620_a_at

16873562

206187_at

3866095

3866096

3866101

3866104

5739

758_at

8037775

A_23_P340848

A_24_P322426

D38128_at

GE901484

GO:0002376

GO:0002862

GO:0003674

GO:0004930

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0005886

GO:0005887

GO:0006950

GO:0006954

GO:0007165

GO:0007186

GO:0007187

GO:0007189

GO:0007204

GO:0007267

GO:0008150

GO:0008283

GO:0010642

GO:0016020

GO:0016021

GO:0016501

GO:0032496

GO:0042592

GO:0048662

HMNXSV003009353

Hs2.393.2.S1_3p_s_at

ILMN_1747023

ILMN_1784303

PH_hs_0026352

TC19001650.hg

g4506262_3p_at

Participates

as an output of

Dissociation of the Prostacyclin receptor:Gs complex (Homo sapiens)

as an input of

IP receptor can bind prostacyclin (Homo sapiens)

as a member of

GPCRs that activate Gs [plasma membrane] (Homo sapiens)

as a component of

PTGIR:PGI2 [plasma membrane] (Homo sapiens)

Inferred To

Ptgir [plasma membrane] (Mus musculus)

Ptgir [plasma membrane] (Rattus norvegicus)

BcDNA:GH27361 [plasma membrane] (Drosophila melanogaster)

PTGIR [plasma membrane] (Sus scrofa)

ptgir [plasma membrane] (Danio rerio)

ptgir [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_000951.1

ZINC - World Drugs

PI2R_HUMAN

Guide to Pharmacology - Targets

345

OpenTargets

ENSG00000160013

ZINC - FDA approved

PI2R_HUMAN

ZINC - Substances

PI2R_HUMAN

ZINC target

P43119

ZINC - Biogenic

PI2R_HUMAN

PRO

P43119

GlyGen

P43119

ZINC - Investigational

PI2R_HUMAN

ZINC - Metabolites

PI2R_HUMAN

GeneCards

P43119

HPA

ENSG00000160013-PTGIR

Ensembl

ENSP00000291294, ENST00000291294, ENSG00000160013

Pharos - Targets

P43119

ZINC - Predictions - Purchasable

PI2R_HUMAN

HMDB Protein

HMDBP02751

Cite Us!