IP receptor can bind prostacyclin

Stable Identifier
Reaction [binding]
Homo sapiens
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Prostacyclin (PGI2) prevents formation of the platelet plug involved in primary hemostasis (a part of blood clot formation) and is an effective vasodilator. Binding to its receptor (IP, PTGIR) (Boie et al. 1994) allows coupling to and activation of the G protein alpha s subunit, which leads to activation of cAMP and increase in protein kinase A (PKA) activity (Schwaner et al. 1995).
Literature References
PubMed ID Title Journal Year
12446735 The unique ligand-binding pocket for the human prostacyclin receptor. Site-directed mutagenesis and molecular modeling

Merenick, BL, Stojanovic, A, Stitham, J, O'Hara, KA, Hwa, J

J Biol Chem 2003
7512962 Cloning and expression of a cDNA for the human prostanoid IP receptor

Rushmore, TH, Slipetz, DM, Boie, Y, Abramovitz, M, Darmon-Goodwin, A, Metters, KM, Grygorczyk, R

J Biol Chem 1994
7532011 Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL

Schultz, G, Offermanns, S, Spicher, K, Seifert, R, Schwaner, I

Biochim Biophys Acta 1995
2474350 Functional and ligand binding studies suggest heterogeneity of platelet prostacyclin receptors

Lawrence, RA, Wilson, NH, Jones, RL, Collier, A, Armstrong, RA

Br J Pharmacol 1989
7514139 Cloning and expression of a cDNA for the human prostacyclin receptor

Irie, A, Ichikawa, A, Narumiya, S, Namba, T, Sugimoto, Y, Negishi, M, Katsuyama, M

FEBS Lett 1994
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