Reactome | IP receptor can bind prostacyclin

IP receptor can bind prostacyclin

Stable Identifier

R-HSA-391942

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Eicosanoid ligand-binding receptors (Homo sapiens)
        
        Prostanoid ligand receptors (Homo sapiens)
        
        IP receptor can bind prostacyclin (Homo sapiens)

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Prostacyclin (PGI2) prevents formation of the platelet plug involved in primary hemostasis (a part of blood clot formation) and is an effective vasodilator. Binding to its receptor (IP, PTGIR) (Boie et al. 1994) allows coupling to and activation of the G protein alpha s subunit, which leads to activation of cAMP and increase in protein kinase A (PKA) activity (Schwaner et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
12446735	The unique ligand-binding pocket for the human prostacyclin receptor. Site-directed mutagenesis and molecular modeling Merenick, BL, Stojanovic, A, Stitham, J, O'Hara, KA, Hwa, J	J Biol Chem	2003
7512962	Cloning and expression of a cDNA for the human prostanoid IP receptor Rushmore, TH, Slipetz, DM, Boie, Y, Abramovitz, M, Darmon-Goodwin, A, Metters, KM, Grygorczyk, R	J Biol Chem	1994
7532011	Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL Schultz, G, Offermanns, S, Spicher, K, Seifert, R, Schwaner, I	Biochim Biophys Acta	1995
2474350	Functional and ligand binding studies suggest heterogeneity of platelet prostacyclin receptors Lawrence, RA, Wilson, NH, Jones, RL, Collier, A, Armstrong, RA	Br J Pharmacol	1989
7514139	Cloning and expression of a cDNA for the human prostacyclin receptor Irie, A, Ichikawa, A, Narumiya, S, Namba, T, Sugimoto, Y, Negishi, M, Katsuyama, M	FEBS Lett	1994