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PKD2 [Golgi membrane]
Stable Identifier
R-HSA-5623393
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
PC2
Locations in the PathwayBrowser
Expand all
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Cargo trafficking to the periciliary membrane (Homo sapiens)
VxPx cargo-targeting to cilium (Homo sapiens)
ARF4:GTP binds VxPx-motifs of membrane proteins (Homo sapiens)
ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
PKD2 [Golgi membrane] (Homo sapiens)
VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
PKD2 [Golgi membrane] (Homo sapiens)
ASAP1 dimer binds membrane proteins (Homo sapiens)
ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
PKD2 [Golgi membrane] (Homo sapiens)
ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
PKD2 [Golgi membrane] (Homo sapiens)
ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Homo sapiens)
ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
PKD2 [Golgi membrane] (Homo sapiens)
RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
PKD2 [Golgi membrane] (Homo sapiens)
ASAP1 stimulates GTPase activity of ARF4 (Homo sapiens)
RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
PKD2 [Golgi membrane] (Homo sapiens)
RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
PKD2 [Golgi membrane] (Homo sapiens)
Cargo-carrying vesicles bud from the TGN (Homo sapiens)
RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
PKD2 [Golgi membrane] (Homo sapiens)
RAB3IP and RAB8A bind to the ciliary targeting complex (Homo sapiens)
RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
PKD2 [Golgi membrane] (Homo sapiens)
RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
PKD2 [Golgi membrane] (Homo sapiens)
RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
PKD2 [Golgi membrane] (Homo sapiens)
RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
PKD2 [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13563 PKD2
Gene Names
PKD2, TRPP2
Chain
chain:1-968
Reference Genes
BioGPS Gene:5311 PKD2
COSMIC (genes):PKD2 PKD2
CTD Gene:5311 PKD2
dbSNP Gene:5311 PKD2
ENSEMBL:ENSG00000118762 PKD2
ENSEMBL:ENSG00000118762.8 PKD2
HGNC:9009 PKD2
KEGG Gene (Homo sapiens):5311 PKD2
Monarch:5311 PKD2
NCBI Gene:5311 PKD2
OMIM:173910 PKD2
UCSC:Q13563 PKD2
Reference Transcript
RefSeq:NM_000297.3 PKD2
Other Identifiers
11718653_a_at
11718654_s_at
11751369_a_at
16968697
203688_PM_at
203688_at
2735223
2735224
2735225
2735226
2735237
2735249
2735250
2735251
2735252
2735253
2735257
2735258
2735259
2735261
2735263
2735264
2735265
2735266
2735267
2735268
2735269
2735270
34170_s_at
38120_at
5311
8096314
A_14_P119717
A_23_P167324
A_24_P106112
GE59212
GO:0000278
GO:0001658
GO:0001822
GO:0001889
GO:0001892
GO:0001947
GO:0002133
GO:0003127
GO:0005102
GO:0005215
GO:0005244
GO:0005245
GO:0005248
GO:0005249
GO:0005261
GO:0005262
GO:0005267
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005783
GO:0005789
GO:0005794
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005929
GO:0006351
GO:0006355
GO:0006811
GO:0006813
GO:0006816
GO:0006874
GO:0007010
GO:0007204
GO:0007259
GO:0007368
GO:0007507
GO:0008092
GO:0008285
GO:0009925
GO:0010628
GO:0015267
GO:0015271
GO:0016020
GO:0016055
GO:0016323
GO:0021510
GO:0021915
GO:0022843
GO:0023052
GO:0030027
GO:0030659
GO:0031410
GO:0031514
GO:0031587
GO:0034614
GO:0034703
GO:0034765
GO:0035502
GO:0035725
GO:0035904
GO:0036064
GO:0036211
GO:0042127
GO:0042802
GO:0042803
GO:0042805
GO:0042994
GO:0042995
GO:0043226
GO:0043398
GO:0044325
GO:0044782
GO:0045180
GO:0045429
GO:0045737
GO:0045944
GO:0046872
GO:0048763
GO:0048856
GO:0050982
GO:0051117
GO:0051209
GO:0051219
GO:0051262
GO:0051289
GO:0051290
GO:0051298
GO:0051371
GO:0051393
GO:0051649
GO:0051726
GO:0055065
GO:0055085
GO:0060170
GO:0060315
GO:0060674
GO:0061333
GO:0061441
GO:0065003
GO:0070062
GO:0070588
GO:0071277
GO:0071320
GO:0071464
GO:0071470
GO:0071498
GO:0071805
GO:0071910
GO:0072075
GO:0072164
GO:0072177
GO:0072208
GO:0072214
GO:0072218
GO:0072219
GO:0072235
GO:0072284
GO:0072686
GO:0090279
GO:0097730
GO:0098553
GO:0098554
GO:0098662
GO:0110165
GO:0198738
GO:2000134
HMNXSV003047915
ILMN_1807300
ILMN_2052891
PH_hs_0026338
TC04000480.hg
U50928_at
g4505834_3p_at
Participates
as a candidate of
VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
Other forms of this molecule
PKD2 [Golgi-associated vesicle membrane]
PKD2 [ciliary membrane]
Inferred To
PKD2 [Golgi membrane]
(Bos taurus)
PKD2 [Golgi membrane]
(Canis familiaris)
PKD2 [Golgi membrane]
(Danio rerio)
PKD2 [Golgi membrane]
(Gallus gallus)
PKD2 [Golgi membrane]
(Mus musculus)
PKD2 [Golgi membrane]
(Sus scrofa)
Pkd2 [Golgi membrane]
(Rattus norvegicus)
pkd2 [Golgi membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000288.1
Guide to Pharmacology - Targets
504
OpenTargets
ENSG00000118762
ZINC - Substances
PKD2_HUMAN
ZINC target
Q13563
PRO
Q13563
PDB
2KLE
,
5K47
,
5MKE
,
6D1W
,
6WB8
,
6T9O
,
3HRN
,
2KQ6
,
6T9N
,
2Y4Q
,
2KLD
,
3HRO
,
5MKF
,
6A70
,
5T4D
GeneCards
Q13563
HPA
ENSG00000118762-PKD2
Ensembl
ENSP00000237596
,
ENST00000237596
,
ENSG00000118762
Pharos - Targets
Q13563
ZINC - Predictions - Purchasable
PKD2_HUMAN
Orphanet
15099
HMDB Protein
HMDBP07942
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48995 TRPC1
1
TRPC1 [plasma membrane]
(R-HSA-2089937)
0.69
12
UniProt:Q9QZC1 Trpc3
2
Trpc3 [plasma membrane]
(R-MMU-9006040)
TRPC3(1-848) [plasma membrane]
(R-MMU-426172)
0.602
3
UniProt:Q61056
1
Trpc1 [plasma membrane]
(R-MMU-2089937)
0.463
2
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