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SLC9A1 [plasma membrane]
Stable Identifier
R-HSA-426006
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Sodium/hydrogen exchanger 1, SL9A1_HUMAN, NHE1
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Hyaluronan metabolism (Homo sapiens)
Hyaluronan uptake and degradation (Homo sapiens)
HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Homo sapiens)
HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+ [plasma membrane] (Homo sapiens)
SLC9A1:p-CHP:Ca2+ [plasma membrane] (Homo sapiens)
SLC9A1 [plasma membrane] (Homo sapiens)
SLC9A1:p-CHP:Ca2+ [plasma membrane] (Homo sapiens)
SLC9A1 [plasma membrane] (Homo sapiens)
Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Homo sapiens)
HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+ [plasma membrane] (Homo sapiens)
SLC9A1:p-CHP:Ca2+ [plasma membrane] (Homo sapiens)
SLC9A1 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Sodium/Proton exchangers (Homo sapiens)
Na+/H+ exchanger transport (at cell membrane) (Homo sapiens)
SLC9A1-5 [plasma membrane] (Homo sapiens)
SLC9A1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P19634 SLC9A1
Gene Names
SLC9A1, APNH1, NHE1
Chain
chain:1-815
Reference Genes
BioGPS Gene:6548 SLC9A1
COSMIC (genes):SLC9A1 SLC9A1
CTD Gene:6548 SLC9A1
dbSNP Gene:6548 SLC9A1
ENSEMBL:ENSG00000090020 SLC9A1
ENSEMBL:ENSG00000090020.11 SLC9A1
HGNC:11071 SLC9A1
KEGG Gene (Homo sapiens):6548 SLC9A1
Monarch:6548 SLC9A1
NCBI Gene:6548 SLC9A1
OMIM:107310 SLC9A1
UCSC:P19634 SLC9A1
Reference Transcript
RefSeq:NM_003047.4 SLC9A1
Other Identifiers
11718710_a_at
11718711_s_at
11749704_a_at
11761341_at
11761342_x_at
1554728_PM_at
1554728_at
16683925
209453_PM_at
209453_at
2402943
2402944
2402945
2402946
2402948
2402949
2402950
2402951
2402952
2402954
2402959
2402960
2402961
2402962
2402963
2402964
2402981
2402982
2402983
2402984
2402985
32681_at
6548
7914021
A_24_P350683
A_24_P71373
GE62362
GO:0002026
GO:0003012
GO:0003013
GO:0005215
GO:0005515
GO:0005516
GO:0005543
GO:0005546
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005783
GO:0005789
GO:0005886
GO:0005925
GO:0006351
GO:0006355
GO:0006811
GO:0006812
GO:0006814
GO:0006883
GO:0006885
GO:0007005
GO:0007010
GO:0007155
GO:0007163
GO:0008289
GO:0009986
GO:0010447
GO:0010613
GO:0010882
GO:0012501
GO:0014070
GO:0014704
GO:0015297
GO:0015299
GO:0015385
GO:0015386
GO:0016020
GO:0016323
GO:0016324
GO:0016477
GO:0023052
GO:0030011
GO:0030027
GO:0030154
GO:0030307
GO:0030315
GO:0030346
GO:0030674
GO:0032869
GO:0034330
GO:0035794
GO:0035994
GO:0036376
GO:0042383
GO:0042802
GO:0043065
GO:0043066
GO:0043167
GO:0043226
GO:0045121
GO:0045760
GO:0045944
GO:0048306
GO:0048471
GO:0048856
GO:0048863
GO:0048870
GO:0051259
GO:0051453
GO:0051492
GO:0051893
GO:0055007
GO:0055065
GO:0055085
GO:0060090
GO:0061024
GO:0065003
GO:0070062
GO:0070417
GO:0070886
GO:0071236
GO:0071257
GO:0071260
GO:0071407
GO:0071456
GO:0071468
GO:0071805
GO:0071872
GO:0086003
GO:0086036
GO:0086040
GO:0086092
GO:0090533
GO:0098719
GO:0098735
GO:1902533
GO:1902600
GO:1903281
GO:1990351
HMNXSV003005666
HMNXSV003016168
Hs2.170222.2.S1_3p_at
ILMN_1800425
PH_hs_0010164
S68616_at
TC01002401.hg
TC01005354.hg
g178752_3p_at
Participates
as a member of
SLC9A1-5 [plasma membrane] (Homo sapiens)
as a component of
SLC9A1:p-CHP:Ca2+ [plasma membrane] (Homo sapiens)
Inferred To
nhe1 [plasma membrane]
(Dictyostelium discoideum)
slc9a1 [plasma membrane]
(Xenopus tropicalis)
Slc9a1 [plasma membrane]
(Mus musculus)
Slc9a1 [plasma membrane]
(Rattus norvegicus)
nhe2 [plasma membrane]
(Dictyostelium discoideum)
Homologues of SLC9A1 [plasma membrane]
(Dictyostelium discoideum)
SLC9A1 [plasma membrane]
(Bos taurus)
SLC9A1 [plasma membrane]
(Canis familiaris)
SLC9A1 [plasma membrane]
(Danio rerio)
SLC9A1 [plasma membrane]
(Gallus gallus)
SLC9A1 [plasma membrane]
(Sus scrofa)
nhx-1 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_003038.2
Guide to Pharmacology - Targets
948
OpenTargets
ENSG00000090020
ZINC - Substances
SL9A1_HUMAN
ZINC target
P19634
PRO
P19634
PDB
7DSV
,
2MDF
,
2KBV
,
2BEC
,
2L0E
,
6NUF
,
2YGG
,
1Y4E
,
7DSX
,
2HTG
,
7DSW
,
2E30
,
6NUU
,
6NUC
,
6BJF
,
6ZBI
ZINC - Investigational
SL9A1_HUMAN
GeneCards
P19634
HPA
ENSG00000090020-SLC9A1
Ensembl
ENST00000263980
,
ENST00000374086
,
ENSP00000363199
,
ENSP00000263980
,
ENSG00000090020
Pharos - Targets
P19634
Orphanet
23694
ZINC - Predictions - Purchasable
SL9A1_HUMAN
HMDB Protein
HMDBP02555
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.678
4
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