Reactome | GLMN [cytosol]

GLMN [cytosol]

Stable Identifier

R-HSA-8951779

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Glomulin, GLMN_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
      - Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
        
        GLMN [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
        
        GLMN [cytosol] (Homo sapiens)
      - Polyubiquitination of substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
        
        GLMN [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
        
        GLMN [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
        
        GLMN [cytosol] (Homo sapiens)
      - Release of E3 from polyubiquitinated substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
        
        GLMN [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
        
        GLMN [cytosol] (Homo sapiens)
      - Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
        
        GLMN [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
        
        GLMN [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
        
        GLMN [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92990 GLMN

Gene Names

GLMN, FAP48, FAP68, VMGLOM

Chain

initiator methionine:, chain:2-594

Reference Genes

BioGPS Gene:11146 GLMN

COSMIC (genes):GLMN GLMN

CTD Gene:11146 GLMN

dbSNP Gene:11146 GLMN

ENSEMBL:ENSG00000174842 GLMN

HGNC:14373 GLMN

KEGG:hsa:11146 GLMN

Monarch:11146 GLMN

NCBI Gene:11146 GLMN

OMIM:601749 GLMN

UCSC:Q92990 GLMN

Reference Transcript

Other Identifiers

11146

11728835_a_at

16689581

207153_PM_s_at

207153_s_at

2422892

2422893

2422894

2422895

2422896

2422897

2422898

2422900

2422901

2422902

2422909

2422910

2422911

2422912

2422913

2422914

2422915

2422916

2422917

2422918

2422919

2422923

2422925

2422926

2422929

2422930

2422931

2422934

2422935

2422936

2422937

2422938

2422939

2422940

39983_at

39984_g_at

39985_r_at

7917676

A_23_P160742

GE59389

GE84823

GO:0001570

GO:0001819

GO:0001843

GO:0005102

GO:0005171

GO:0005515

GO:0005737

GO:0006325

GO:0007166

GO:0008285

GO:0030154

GO:0031461

GO:0031462

GO:0031463

GO:0031464

GO:0031625

GO:0032434

GO:0032743

GO:0040029

GO:0042130

GO:0042327

GO:0042692

GO:0048856

GO:0055105

GO:0072359

GO:0098772

HMNXSV003043742

ILMN_1739397

ILMN_1749448

PH_hs_0003429

TC01002866.hg

U73704_at

g5901949_3p_a_at

Participates

as a component of

RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)

Inferred To

Glmn [cytosol] (Mus musculus)

Glmn [cytosol] (Rattus norvegicus)

glmn [cytosol] (Xenopus tropicalis)

GLMN [cytosol] (Bos taurus)

GLMN [cytosol] (Canis familiaris)

GLMN [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_011538848.1, NP_444504.1, NP_001306612.1

ENSEMBL

ENSP00000359385, ENSP00000436829, ENST00000495106, ENST00000370360

OpenTargets

ENSG00000174842

HPA

ENSG00000174842-GLMN

PRO

Q92990

Pharos - Targets

Q92990

GlyGen

Q92990

Orphanet

GLMN

PDB

4F52

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q02790 FKBP4	3	FKBP4 [nucleoplasm] (R-HSA-8939162) FKBP4 [nucleoplasm] (R-HSA-5324621) FKBP4 [cytosol] (R-HSA-5618108)	0.742	5
UniProt:P62877 RBX1	2	RBX1 [cytosol] (R-HSA-180582) RBX1 [nucleoplasm] (R-HSA-1234142)	0.666	7
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.643	4
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.556	3
UniProt:Q6UWR7 ENPP6	1	ENPP6 [plasma membrane] (R-HSA-6814799)	0.527	2
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.527	3
UniProt:Q14653 IRF3	6	IRF3 [cytosol] (R-HSA-166251) IRF3(2-271) [cytosol] (R-HSA-9729696) IRF3(272-427) [cytosol] (R-HSA-9729737) p-4S,T404-IRF3 [cytosol] (R-HSA-166258) p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418)	0.527	2
UniProt:P15907 ST6GAL1	1	ST6GAL1 [Golgi membrane] (R-HSA-975899)	0.527	2
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519)	0.527	2
UniProt:Q86XL3 ANKLE2	2	Ac-K302-ANKLE2 [endoplasmic reticulum membrane] (R-HSA-9667946) ANKLE2 [endoplasmic reticulum membrane] (R-HSA-2529000)	0.527	2
UniProt:O75695 RP2	1	RP2 [cilium] (R-HSA-5624052)	0.527	2
UniProt:P43119 PTGIR	1	PTGIR [plasma membrane] (R-HSA-391834)	0.527	2
UniProt:Q9BQ90 KLHDC3	1	KLHDC3 [cytosol] (R-HSA-535552)	0.527	2
UniProt:P43630 KIR3DL2	1	KIR3DL2 [plasma membrane] (R-HSA-197713)	0.527	2
UniProt:Q14999 CUL7	1	CUL7 [cytosol] (R-HSA-535534)	0.527	4