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SLC15A4 [endolysosome membrane]
Stable Identifier
R-HSA-9860282
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endolysosome membrane
Synonyms
PHT1, Solute carrier family 15 member 4, S15A4_HUMAN, Peptide/histidine transporter 1
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
SLC15A4:TASL-dependent IRF5 activation (Homo sapiens)
Activated IKBKB phosphorylates IRF5 (Homo sapiens)
SLC15A4:p-S-TASL:IRF5 [endolysosome membrane] (Homo sapiens)
SLC15A4:p-S294-TASL [endolysosome membrane] (Homo sapiens)
SLC15A4 [endolysosome membrane] (Homo sapiens)
SLC15A4:p-S294-TASL [endolysosome membrane] (Homo sapiens)
SLC15A4 [endolysosome membrane] (Homo sapiens)
SLC15A4 binds TASL (Homo sapiens)
SLC15A4:SLC15A4 [endolysosome membrane] (Homo sapiens)
SLC15A4 [endolysosome membrane] (Homo sapiens)
SLC15A4:TASL [endolysosome membrane] (Homo sapiens)
SLC15A4 [endolysosome membrane] (Homo sapiens)
TASL is phosphorylated (Homo sapiens)
SLC15A4:TASL [endolysosome membrane] (Homo sapiens)
SLC15A4 [endolysosome membrane] (Homo sapiens)
SLC15A4:p-S294-TASL [endolysosome membrane] (Homo sapiens)
SLC15A4 [endolysosome membrane] (Homo sapiens)
TASL recruits IRF5 (Homo sapiens)
SLC15A4:p-S-TASL:IRF5 [endolysosome membrane] (Homo sapiens)
SLC15A4:p-S294-TASL [endolysosome membrane] (Homo sapiens)
SLC15A4 [endolysosome membrane] (Homo sapiens)
SLC15A4:p-S294-TASL [endolysosome membrane] (Homo sapiens)
SLC15A4 [endolysosome membrane] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
SLC15A4:TASL-dependent IRF5 activation (Homo sapiens)
Activated IKBKB phosphorylates IRF5 (Homo sapiens)
SLC15A4:p-S-TASL:IRF5 [endolysosome membrane] (Homo sapiens)
SLC15A4:p-S294-TASL [endolysosome membrane] (Homo sapiens)
SLC15A4 [endolysosome membrane] (Homo sapiens)
SLC15A4:p-S294-TASL [endolysosome membrane] (Homo sapiens)
SLC15A4 [endolysosome membrane] (Homo sapiens)
SLC15A4 binds TASL (Homo sapiens)
SLC15A4:SLC15A4 [endolysosome membrane] (Homo sapiens)
SLC15A4 [endolysosome membrane] (Homo sapiens)
SLC15A4:TASL [endolysosome membrane] (Homo sapiens)
SLC15A4 [endolysosome membrane] (Homo sapiens)
TASL is phosphorylated (Homo sapiens)
SLC15A4:TASL [endolysosome membrane] (Homo sapiens)
SLC15A4 [endolysosome membrane] (Homo sapiens)
SLC15A4:p-S294-TASL [endolysosome membrane] (Homo sapiens)
SLC15A4 [endolysosome membrane] (Homo sapiens)
TASL recruits IRF5 (Homo sapiens)
SLC15A4:p-S-TASL:IRF5 [endolysosome membrane] (Homo sapiens)
SLC15A4:p-S294-TASL [endolysosome membrane] (Homo sapiens)
SLC15A4 [endolysosome membrane] (Homo sapiens)
SLC15A4:p-S294-TASL [endolysosome membrane] (Homo sapiens)
SLC15A4 [endolysosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N697 SLC15A4
Gene Names
SLC15A4, PHT1, PTR4, FP12591
Chain
chain:1-577
Reference Genes
BioGPS Gene:121260 SLC15A4
COSMIC (genes):SLC15A4 SLC15A4
CTD Gene:121260 SLC15A4
dbSNP Gene:121260 SLC15A4
ENSEMBL:ENSG00000139370 SLC15A4
HGNC:23090 SLC15A4
KEGG:hsa:121260 SLC15A4
Monarch:121260 SLC15A4
NCBI Gene:121260 SLC15A4
OMIM:615806 SLC15A4
UCSC:Q8N697 SLC15A4
Reference Transcript
RefSeq:NM_145648.3 SLC15A4
Other Identifiers
11723178_s_at
121260
16772377
225043_PM_at
225043_at
225057_PM_at
225057_at
3477916
3477918
3477919
3477920
3477921
3477939
3477940
3477941
3477942
3477943
3477947
3477948
3477949
3477950
3477951
3477952
3477953
3477954
3477956
3477957
3477961
3477962
3477963
3477970
3477971
3477972
48564_at
54857_at
7967624
7967636
A_23_P105368
A_23_P98953
A_24_P13311
A_33_P3270315
A_33_P3406449
GE87099
GE87100
GO:0002376
GO:0005215
GO:0005290
GO:0005515
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005886
GO:0006811
GO:0006857
GO:0010008
GO:0015031
GO:0015293
GO:0015333
GO:0015647
GO:0015817
GO:0015833
GO:0015835
GO:0016020
GO:0022857
GO:0031410
GO:0031901
GO:0033023
GO:0034157
GO:0034161
GO:0034165
GO:0035579
GO:0036020
GO:0043226
GO:0045087
GO:0045089
GO:0048302
GO:0055085
GO:0070424
GO:0070430
GO:0070434
GO:0071916
GO:0089708
GO:0098542
GO:0140206
GO:1902600
HMNXSV003021043
HMNXSV003021810
HMNXSV003022285
HMNXSV003028596
HMNXSV003033500
Hs.175043.1.A1_3p_at
Hs.175043.1.A2_3p_at
ILMN_1679731
PH_hs_0023370
PH_hs_0034896
TC12002122.hg
TC12002123.hg
TC12003166.hg
Participates
as a component of
SLC15A4:SLC15A4 [endolysosome membrane] (Homo sapiens)
SLC15A4:TASL [endolysosome membrane] (Homo sapiens)
SLC15A4:p-S294-TASL [endolysosome membrane] (Homo sapiens)
Other forms of this molecule
SLC15A4 [lysosomal membrane]
SLC15A4 [plasma membrane]
SLC15A4 [specific granule membrane]
Inferred To
slc15a4 [endolysosome membrane]
(Xenopus tropicalis)
PTR2 [endolysosome membrane]
(Saccharomyces cerevisiae)
ptr2 [endolysosome membrane]
(Schizosaccharomyces pombe)
SLC15A4 [endolysosome membrane]
(Bos taurus)
SLC15A4 [endolysosome membrane]
(Canis familiaris)
SLC15A4 [endolysosome membrane]
(Gallus gallus)
SLC15A4 [endolysosome membrane]
(Sus scrofa)
Slc15a4 [endolysosome membrane]
(Mus musculus)
Slc15a4 [endolysosome membrane]
(Rattus norvegicus)
Cross References
Guide to Pharmacology - Targets
987
ENSEMBL
ENSP00000266771
,
ENST00000266771
OpenTargets
ENSG00000139370
HPA
ENSG00000139370-SLC15A4
PRO
Q8N697
Pharos - Targets
Q8N697
GlyGen
Q8N697
HMDB Protein
HMDBP13948
PDB
8WX3
,
8QSM
,
8QSK
,
8JZS
,
8WX4
,
8QSN
,
8WX5
,
8JZU
,
8QSL
,
8JZX
,
8JZR
,
8P6A
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9HAI6 TASL
2
TASL [cytosol]
(R-HSA-9860303)
p-S294-TASL [cytosol]
(R-HSA-9860284)
0.811
15
UniProt:P17931 LGALS3
3
LGALS3 [ficolin-1-rich granule membrane]
(R-HSA-6803307)
LGALS3 [plasma membrane]
(R-HSA-879445)
LGALS3 [secretory granule membrane]
(R-HSA-6803327)
0.643
5
UniProt:O00182 LGALS9
1
LGALS9 [extracellular region]
(R-HSA-5215932)
0.527
3
UniProt:P43119 PTGIR
1
PTGIR [plasma membrane]
(R-HSA-391834)
0.527
2
UniProt:Q13568 IRF5
3
IRF5 [cytosol]
(R-HSA-1015676)
p-S446-IRF5 [cytosol]
(R-HSA-9860271)
p-S446-IRF5 [nucleoplasm]
(R-HSA-9860304)
0.462
2
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