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PTGIR:PGI2 [plasma membrane]
Stable Identifier
R-HSA-391929
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
IP receptor:Prostacyclin
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Prostacyclin signalling through prostacyclin receptor (Homo sapiens)
Activated prostacyclin receptor binds G-protein Gs (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
Dissociation of the Prostacyclin receptor:Gs complex (Homo sapiens)
Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
Gs activation by prostacyclin receptor (Homo sapiens)
Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
IP receptor can bind prostacyclin (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Eicosanoid ligand-binding receptors (Homo sapiens)
Prostanoid ligand receptors (Homo sapiens)
IP receptor can bind prostacyclin (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
Participants
components
PGI2 [extracellular region]
PTGIR [plasma membrane] (Homo sapiens)
Participant Of
input
Activated prostacyclin receptor binds G-protein Gs
hasComponent
Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane]
Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane]
output
IP receptor can bind prostacyclin
hasMember
Ligand:GPCR complexes that activate Gs [plasma membrane]
Inferred To
PTGIR:PGI2 [plasma membrane] (Canis familiaris)
PTGIR:PGI2 [plasma membrane] (Danio rerio)
PTGIR:PGI2 [plasma membrane] (Drosophila melanogaster)
PTGIR:PGI2 [plasma membrane] (Mus musculus)
PTGIR:PGI2 [plasma membrane] (Rattus norvegicus)
PTGIR:PGI2 [plasma membrane] (Sus scrofa)
PTGIR:PGI2 [plasma membrane] (Xenopus tropicalis)
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