Dissociation of the Prostacyclin receptor:Gs complex

Stable Identifier
R-HSA-392874
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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Dissociation of the Prostacyclin receptor:Gs complex
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The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (s) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).
Literature References
PubMed ID Title Journal Year
18577758 Dissociation of heterotrimeric g proteins in cells

Lambert, NA

Sci Signal 2008
3141418 Subunit dissociation is the mechanism for hormonal activation of the Gs protein in native membranes

Ransnäs, LA, Insel, PA

J Biol Chem 1988
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Input
Output
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as an event of
Inferred From
Dissociation of beta-2 adrenergic receptor:Gs complex (Oryctolagus cuniculus)
Authored
Akkerman, JW  (2009-06-03)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-03-09)
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