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Beta-oxidation of very long chain fatty acids
Stable Identifier
R-HSA-390247
Type
Pathway
Species
Homo sapiens
Compartment
peroxisomal matrix
ReviewStatus
5/5
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Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Peroxisomal lipid metabolism (Homo sapiens)
Beta-oxidation of very long chain fatty acids (Homo sapiens)
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Linear fatty acids containing more than 18 carbons are broken down by beta-oxidation in peroxisomes to yield acetyl-CoA and medium chain-length fatty acyl CoA's such as octanoyl-CoA (Wanders and Waterham 2006).
Literature References
PubMed ID
Title
Journal
Year
16756494
Biochemistry of mammalian peroxisomes revisited
Wanders, RJA
,
Waterham, HR
Annu Rev Biochem
2006
Participants
Events
Peroxisomal uptake of very long-chain fatty acyl CoA
(Homo sapiens)
SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH
(Homo sapiens)
ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA
(Homo sapiens)
ACOX1 oxidizes C26:0 CoA
(Homo sapiens)
HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA
(Homo sapiens)
EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA
(Homo sapiens)
HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA
(Homo sapiens)
EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA
(Homo sapiens)
3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA
(Homo sapiens)
Beta-oxidation of tetradecenoyl-CoA to octanoyl-CoA
(Homo sapiens)
malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome
(Homo sapiens)
DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA
(Homo sapiens)
Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA
(Homo sapiens)
Participates
as an event of
Peroxisomal lipid metabolism (Homo sapiens)
Event Information
Go Biological Process
fatty acid beta-oxidation using acyl-CoA oxidase (0033540)
Orthologous Events
Beta-oxidation of very long chain fatty acids (Bos taurus)
Beta-oxidation of very long chain fatty acids (Caenorhabditis elegans)
Beta-oxidation of very long chain fatty acids (Canis familiaris)
Beta-oxidation of very long chain fatty acids (Danio rerio)
Beta-oxidation of very long chain fatty acids (Dictyostelium discoideum)
Beta-oxidation of very long chain fatty acids (Drosophila melanogaster)
Beta-oxidation of very long chain fatty acids (Gallus gallus)
Beta-oxidation of very long chain fatty acids (Mus musculus)
Beta-oxidation of very long chain fatty acids (Rattus norvegicus)
Beta-oxidation of very long chain fatty acids (Saccharomyces cerevisiae)
Beta-oxidation of very long chain fatty acids (Sus scrofa)
Beta-oxidation of very long chain fatty acids (Xenopus tropicalis)
Authored
D'Eustachio, P (2009-03-16)
Reviewed
Jassal, B (2009-02-27)
Hill, DP (2024-08-02)
Created
D'Eustachio, P (2009-01-23)
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