SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH

Stable Identifier
R-HSA-9914143
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
Synonyms
a very long-chain fatty acid + ATP + CoA => a very long-chain fatty acyl-CoA + AMP + diphosphate
ReviewStatus
5/5
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SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH
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SLC27A1 (Long-chain fatty acid transport protein 1) catalyzes the ATP-dependent ligation of a very long-chain fatty acid and CoASH to form a very long-chain fatty acyl-CoA (Steinberg et al. 1999).
Literature References
PubMed ID Title Journal Year
10198260 Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism

Mihalik, SJ, Watkins, PA, Wang, SJ, Kim, DG, Steinberg, SJ

Biochem Biophys Res Commun 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

very long-chain fatty acid-CoA ligase activity of SLC27A2 [peroxisomal membrane]

Physical Entity
SLC27A2 [peroxisomal membrane] (Homo sapiens)
Activity
very long-chain fatty acid-CoA ligase activity (GO:0031957)
Orthologous Events
SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH (Bos taurus)
SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH (Caenorhabditis elegans)
SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH (Canis familiaris)
SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH (Drosophila melanogaster)
SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH (Gallus gallus)
SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH (Mus musculus)
SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH (Rattus norvegicus)
SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH (Saccharomyces cerevisiae)
SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH (Sus scrofa)
SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH (Xenopus tropicalis)
Cross References
RHEA
Rhea
Authored
D'Eustachio, P  (2024-06-20)
Reviewed
Hill, DP  (2024-08-02)
Created
D'Eustachio, P  (2024-06-20)
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