malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome

Stable Identifier
R-HSA-977317
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
Synonyms
H(+) + malonyl-CoA => acetyl-CoA + CO2
ReviewStatus
5/5
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malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome
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Carboxylation of acetyl-CoA and decarboxylation of malonyl-CoA are two processes that can control the amount of the signal transducer malonyl-CoA in the cell. The decarboxylation is catalysed by MCD enzyme in the peroxisomal matrix (Sacksteder et al, 1999).
Literature References
PubMed ID Title Journal Year
10455107 MCD encodes peroxisomal and cytoplasmic forms of malonyl-CoA decarboxylase and is mutated in malonyl-CoA decarboxylase deficiency

Matalon, R, Gould, SJ, Wanders, RJA, Sacksteder, KA, Morrell, JC

J Biol Chem 1999
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Output
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as an event of
Event Information
Go Biological Process
acyl-CoA metabolic process (0006637)
Catalyst Activity

malonyl-CoA decarboxylase activity of MLYCD(40-493) [peroxisomal matrix]

Physical Entity
MLYCD(40-493) [peroxisomal matrix] (Homo sapiens)
Activity
malonyl-CoA decarboxylase activity (GO:0050080)
Orthologous Events
malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Bos taurus)
malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Caenorhabditis elegans)
malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Canis familiaris)
malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Danio rerio)
malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Dictyostelium discoideum)
malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Gallus gallus)
malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Mus musculus)
malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Rattus norvegicus)
malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Sus scrofa)
malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Xenopus tropicalis)
Cross References
RHEA
Rhea
Authored
Stephan, R  (2010-10-15)
Reviewed
D'Eustachio, P  (2013-05-22)
Hill, DP  (2024-08-02)
Created
Jassal, B  (2010-10-18)
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