malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome

Stable Identifier
R-HSA-977317
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Carboxylation of acetyl-CoA and decarboxylation of malonyl-CoA are two processes that can control the amount of the signal transducer malonyl-CoA in the cell. The decarboxylation is catalysed by MCD enzyme in the peroxisomal matrix (Sacksteder et al, 1999).

Literature References
PubMed ID Title Journal Year
10455107 MCD encodes peroxisomal and cytoplasmic forms of malonyl-CoA decarboxylase and is mutated in malonyl-CoA decarboxylase deficiency

Sacksteder, KA, Morrell, JC, Wanders, RJ, Matalon, R, Gould, SJ

J Biol Chem 1999
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Event Information
Go Biological Process
Catalyst Activity

malonyl-CoA decarboxylase activity of MLYCD(40-493) [peroxisomal matrix]

Orthologous Events
Cross References
Rhea
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