Reactome | Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA

Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA

Stable Identifier

R-HSA-5690042

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

a fatty acyl-CoA + H2O => a fatty acid + CoA + H(+)

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The maintenance/regulation of cellular levels of free fatty acids and fatty acyl-CoAs (the activated form of free fatty acids) is extremely important, as imbalances in lipid metabolism can have serious consequences for human health. Free fatty acids can act as detergents to disrupt membranes so their generation is normally tightly regulated to states where they will be rapidly consumed or sequestered. Acyl-coenzyme A (CoA) thioesterases (ACOTs) hydrolyse medium- to long-chain fatty acyl-CoAs (of C12-C18 lengths) (MCFA-CoA, LCFA-CoA) to their corresponding free fatty acids (MCFA, LCFA) and CoASH. ACOTs located in peroxisomes are ACOT4, 6 and 8 (Hunt et al. 2006, Hunt et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
11673457	Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism Hunt, MC, Solaas, K, Kase, BF, Alexson, SE	J Biol Chem	2002
16940157	Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs Hunt, MC, Rautanen, A, Westin, MA, Svensson, LT, Alexson, SE	FASEB J.	2006