Reactome | Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA

Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA

Stable Identifier

R-HSA-5690042

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

a fatty acyl-CoA + H2O => a fatty acid + CoA + H(+)

ReviewStatus

5/5

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Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA

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The maintenance/regulation of cellular levels of free fatty acids and fatty acyl-CoAs (the activated form of free fatty acids) is extremely important, as imbalances in lipid metabolism can have serious consequences for human health. Free fatty acids can act as detergents to disrupt membranes so their generation is normally tightly regulated to states where they will be rapidly consumed or sequestered. Acyl-coenzyme A (CoA) thioesterases (ACOTs) hydrolyse medium- to long-chain fatty acyl-CoAs (of C12-C18 lengths) (MCFA-CoA, LCFA-CoA) to their corresponding free fatty acids (MCFA, LCFA) and CoASH. ACOTs located in peroxisomes are ACOT4, 6 and 8 (Hunt et al. 2006, Hunt et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
11673457	Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism Kase, BF, Alexson, SE, Solaas, K, Hunt, MC	J Biol Chem	2002
16940157	Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs Westin, MA, Alexson, SE, Svensson, LT, Rautanen, A, Hunt, MC	FASEB J.	2006