DECR2 reduces LCtE-CoA to t3enoyl-CoA

Stable Identifier
R-HSA-6786720
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Saturated and unsaturated fats can undergo beta-oxidation in the mitochondrion and peroxisomes. The only major difference known so far is that peroxisomes can process linear as well as branched unsaturated fatty acid enoyl-CoA esters with much longer chains (>C20) when compared with the mitochondrion. Peroxisomal 2,4-dienoyl-CoA reductase (DECR2) mediates the reduction of long-chain enoyl-CoA esters (LCtE-CoA) to form trans-3-enoyl-CoA esters (t3enoyl-CoA) (De Nys et al. 2001, Hua et al. 2012). DECR2 functions as an auxiliary enzyme for fatty acid beta-oxidation where very long-chain and long-chain fatty acids are shortened in peroxisomes and shuttled to the mitochondrion for complete degradation.

Literature References
PubMed ID Title Journal Year
11514237 Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase

De Nys, K, Meyhi, E, Mannaerts, GP, Fransen, M, Van Veldhoven, PP

Biochim. Biophys. Acta 2001
22745130 Studies of human 2,4-dienoyl CoA reductase shed new light on peroxisomal β-oxidation of unsaturated fatty acids

Hua, T, Wu, D, Ding, W, Wang, J, Shaw, N, Liu, ZJ

J. Biol. Chem. 2012
Participants
Participates
Catalyst Activity

trans-2-enoyl-CoA reductase (NADPH) activity of DECR2 [peroxisomal membrane]

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