Reactome | DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA

DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA

Stable Identifier

R-HSA-6786720

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix, peroxisomal membrane

Synonyms

a (2E,4E)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)

ReviewStatus

5/5

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DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA

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Saturated and unsaturated fats can undergo beta-oxidation in the mitochondrion and peroxisomes. The only major difference known so far is that peroxisomes can process linear as well as branched unsaturated fatty acid enoyl-CoA esters with much longer chains (>C20) when compared with the mitochondrion. Peroxisomal 2,4-dienoyl-CoA reductase (DECR2) mediates the reduction of long-chain enoyl-CoA esters (2,3-dienoyl-CoA) to form 4,5-saturated-(3E)-enoyl-CoA esters (De Nys et al. 2001, Hua et al. 2012). DECR2 functions as an auxiliary enzyme for fatty acid beta-oxidation where very long-chain and long-chain fatty acids are shortened in peroxisomes and shuttled to the mitochondrion for complete degradation.

Literature References

PubMed ID	Title	Journal	Year
22745130	Studies of human 2,4-dienoyl CoA reductase shed new light on peroxisomal β-oxidation of unsaturated fatty acids Hua, T, Wu, D, Ding, W, Wang, J, Shaw, N, Liu, ZJ	J. Biol. Chem.	2012
11514237	Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase De Nys, K, Meyhi, E, Mannaerts, GP, Fransen, M, Van Veldhoven, PP	Biochim. Biophys. Acta	2001