Reactome | Peroxisomal uptake of very long-chain fatty acyl CoA

Peroxisomal uptake of very long-chain fatty acyl CoA

Stable Identifier

R-HSA-390393

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal membrane

Synonyms

a very long-chain fatty acyl-CoA(out) + ATP + 2 H2O => a very long-chain fatty acid(in) + ADP + CoA + 2 H(+)

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Peroxisomal uptake of very long-chain fatty acyl CoA

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ABCD1 (ATP-binding cassette sub-family D member 1) mediates the ATP-dependent, coupled peroxisomal import and hydrolysis of cytosolic very long chain fatty-acyl-CoA to form peroxisomal very long-chain fatty acid and CoASH (Kawaguchi et al. 2021; van Roermund et al. 2011; van Roermund et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
21145416	Differential substrate specificities of human ABCD1 and ABCD2 in peroxisomal fatty acid β-oxidation van Roermund, CW, Visser, WF, IJlst, L, Waterham, HR, Wanders, RJ	Biochim Biophys Acta	2011
33500543	Acyl-CoA thioesterase activity of peroxisomal ABC protein ABCD1 is required for the transport of very long-chain acyl-CoA into peroxisomes Kawaguchi, K, Mukai, E, Watanabe, S, Yamashita, A, Morita, M, So, T, Imanaka, T	Sci Rep	2021
22493507	Peroxisomal fatty acid uptake mechanism in Saccharomyces cerevisiae van Roermund, CW, IJlst, L, Majczak, W, Waterham, HR, Folkerts, H, Wanders, RJ, Hellingwerf, KJ	J Biol Chem	2012