3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA

Stable Identifier
R-HSA-390250
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
Synonyms
3-oxohexacosanoyl-CoA + CoA => acetyl-CoA + tetracosanoyl-CoA
ReviewStatus
5/5
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3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Peroxisomal ACAA1 catalyzes the reaction of 3-ketohexacosanoyl-CoA and CoASH to form tetracosanoyl-CoA + acetyl-CoA (Bout et al. 1991).
Literature References
PubMed ID Title Journal Year
1679347 Characterization of the gene encoding human peroxisomal 3-oxoacyl-CoA thiolase (ACAA). No large DNA rearrangement in a thiolase-deficient patient

Bout, A, Franse, MM, Collins, J, Blonden, L, Tager, JM, Benne, R

Biochim Biophys Acta 1991
Participants
Input
Output
Participates
as an event of
Catalyst Activity

acetyl-CoA C-acyltransferase activity of ACAA1 [peroxisomal matrix]

Physical Entity
ACAA1 [peroxisomal matrix] (Homo sapiens)
Activity
acetyl-CoA C-acyltransferase activity (GO:0003988)
Orthologous Events
3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Bos taurus)
3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Canis familiaris)
3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Danio rerio)
3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Dictyostelium discoideum)
3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Gallus gallus)
3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Mus musculus)
3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Rattus norvegicus)
3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Saccharomyces cerevisiae)
3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Sus scrofa)
3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Xenopus tropicalis)
Cross References
RHEA
Authored
D'Eustachio, P  (2009-03-16)
Reviewed
Jassal, B  (2009-02-27)
Created
D'Eustachio, P  (2009-01-23)
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