Reactome | ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA

ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA

Stable Identifier

R-HSA-6809808

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

(3Z)-octenoyl-CoA => (2E)-octenoyl-CoA

ReviewStatus

5/5

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ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA

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ECI2 in the peroxisome matrix catalyzes the isomerizeation of 3Z-enoyl-CoA to 2E-enoyl-CoA. The active form of the enzyme is a homotrimer (Onwukwe et al. 2015). The reaction annotated here, involving octenoyl-CoA isomers is the one originally characterized by Geisbrecht et al. (1999), although the enzyme is active on enoyl-CoAs of a range of chain lengths.

Literature References

PubMed ID	Title	Journal	Year
25515061	Human Δ³,Δ²-enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role of its ACBP domain and helix-10 Onwukwe, GU, Kursula, P, Koski, MK, Schmitz, W, Wierenga, RK	FEBS J.	2015
10419495	Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes Geisbrecht, BV, Zhang, D, Schulz, H, Gould, SJ	J. Biol. Chem.	1999