Reactome | ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA

ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA

Stable Identifier

R-HSA-6809808

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

(3Z)-octenoyl-CoA => (2E)-octenoyl-CoA

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ECI2 in the peroxisome matrix catalyzes the isomerizeation of 3Z-enoyl-CoA to 2E-enoyl-CoA. The active form of the enzyme is a homotrimer (Onwukwe et al. 2015). The reaction annotated here, involving octenoyl-CoA isomers is the one originally characterized by Geisbrecht et al. (1999), although the enzyme is active on enoyl-CoAs of a range of chain lengths.

Literature References

PubMed ID	Title	Journal	Year
25515061	Human Δ³,Δ²-enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role of its ACBP domain and helix-10 Koski, MK, Onwukwe, GU, Kursula, P, Wierenga, RK, Schmitz, W	FEBS J.	2015
10419495	Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes Zhang, D, Schulz, H, Geisbrecht, BV, Gould, SJ	J. Biol. Chem.	1999