ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA

Stable Identifier
R-HSA-6809808
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ECI2 in the peroxisome matrix catalyzes the isomerizeation of 3Z-enoyl-CoA to 2E-enoyl-CoA. The active form of the enzyme is a homotrimer (Onwukwe et al. 2015). The reaction annotated here, involving octenoyl-CoA isomers is the one originally characterized by Geisbreacht et al. (1999), although the enzyme is active on enoyl-CoAs of a range of chain lengths.

Literature References
PubMed ID Title Journal Year
10419495 Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes

Geisbrecht, BV, Zhang, D, Schulz, H, Gould, SJ

J. Biol. Chem. 1999
25515061 Human Δ³,Δ²-enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role of its ACBP domain and helix-10

Onwukwe, GU, Kursula, P, Koski, MK, Schmitz, W, Wierenga, RK

FEBS J. 2015
Participants
Participates
Catalyst Activity

dodecenoyl-CoA delta-isomerase activity of ECI2 trimer [peroxisomal matrix]

Orthologous Events
Cross References
Rhea
Authored
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