Reactome | SOST [extracellular region]

SOST [extracellular region]

Stable Identifier

R-HSA-3769322

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Sclerostin

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9BQB4 SOST

Gene Names

SOST, UNQ2976/PRO7455/PRO7476

Chain

signal peptide:1-23, chain:24-213

Reference Genes

BioGPS Gene:50964 SOST

COSMIC (genes):SOST SOST

CTD Gene:50964 SOST

dbSNP Gene:50964 SOST

ENSEMBL:ENSG00000167941 SOST

HGNC:13771 SOST

KEGG:hsa:50964 SOST

Monarch:50964 SOST

NCBI Gene:50964 SOST

OMIM:605740 SOST

UCSC:Q9BQB4 SOST

Reference Transcript

RefSeq:NM_025237.2 SOST

Other Identifiers

11727328_at

11727329_at

16845440

223869_PM_at

223869_at

3758607

3758608

3758613

50964

77335_at

8015827

A_23_P118571

GE83138

GO:0001503

GO:0005515

GO:0005576

GO:0005615

GO:0005794

GO:0006355

GO:0008201

GO:0009612

GO:0016055

GO:0030178

GO:0030246

GO:0030279

GO:0030312

GO:0030509

GO:0030514

GO:0031012

GO:0031333

GO:0032991

GO:0036122

GO:0043226

GO:0045893

GO:0060070

GO:0062023

GO:0071374

GO:0090090

GO:0098772

GO:0140297

GO:0140678

HMNXSV003054420

ILMN_1700705

ILMN_1781242

PH_hs_0016850

TC17001562.hg

g13236417_3p_at

Participates

as an input of

SOST binds LRP5/6 (Homo sapiens)

as a component of

SOST:LRP5/6 [plasma membrane] (Homo sapiens)

Inferred To

SOST [extracellular region] (Bos taurus)

SOST [extracellular region] (Gallus gallus)

SOST [extracellular region] (Sus scrofa)

Sost [extracellular region] (Mus musculus)

Sost [extracellular region] (Rattus norvegicus)

Cross References

ENSEMBL

ENST00000301691, ENSP00000301691, ENSG00000167941

OpenTargets

ENSG00000167941

GeneCards

SOST

HPA

ENSG00000167941-SOST

PRO

Q9BQB4

Pharos - Targets

Q9BQB4

GlyGen

Q9BQB4

Orphanet

SOST

PDB

6L6R, 3SOV, 2K8P

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75581 LRP6	8	LRP6 [plasma membrane] (R-HSA-206252) p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-1458895) p-2S,S1490,2T-LRP6 [plasma membrane] (R-HSA-1458894) LRP6N [extracellular region] (R-HSA-5334021) p-LRP6 [early endosome membrane] (R-HSA-5368496) LRP6 [early endosome membrane] (R-HSA-5368481) p-S1490-LRP6 [plasma membrane] (R-HSA-206156) p-T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-205884)	0.85	9
UniProt:O75096 LRP4	1	LRP4 [plasma membrane] (R-HSA-2467621)	0.785	6
UniProt:O75197 LRP5	5	LRP5 [plasma membrane] (R-HSA-201671) p-5S,5T-LRP5 [plasma membrane] (R-HSA-1458893) p-3S,2T-LRP5 [plasma membrane] (R-HSA-1458905) LRP5 [early endosome membrane] (R-HSA-5368479) LRP5 D666_L809del [plasma membrane] (R-HSA-5339694)	0.744	5
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.527	3
UniProt:Q96JK2 DCAF5	1	DCAF5 [nucleoplasm] (R-HSA-8955189)	0.527	2
UniProt:P0DML3 CSH2			0.527	2
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.527	2
UniProt:P23378 GLDC	1	PXLP-K754-GLDC [mitochondrial matrix] (R-HSA-5693966)	0.527	2
UniProt:O75439 PMPCB	1	PMPCB [mitochondrial matrix] (R-HSA-1299434)	0.527	3
UniProt:O43791 SPOP	1	SPOP [nucleoplasm] (R-HSA-5635035)	0.527	2
UniProt:P98164 LRP2	2	LRP2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869099) LRP2 [plasma membrane] (R-HSA-350083)	0.527	2
UniProt:Q96LA8 PRMT6	1	PRMT6 [nucleoplasm] (R-HSA-5226884)	0.527	3
UniProt:Q969U7 PSMG2	1	PSMG2 [cytosol] (R-HSA-9908053)	0.527	2
UniProt:Q9BT73 PSMG3	1	PSMG3 [cytosol] (R-HSA-9908033)	0.527	2
UniProt:O95714 HERC2	5	HERC2 [nucleoplasm] (R-HSA-4551680) p-T4827-HERC2 [nucleoplasm] (R-HSA-5682601) p-T4827,SUMO1-HERC2 [nucleoplasm] (R-HSA-5682615) HERC2 [cytosol] (R-HSA-975975) monoSUMO1-HERC2 [nucleoplasm] (R-HSA-4551758)	0.527	3

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