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DCAF5 [nucleoplasm]
Stable Identifier
R-HSA-8955189
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DDB1- and CUL4-associated factor 5, DCAF5_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DCAF5 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DCAF5 [nucleoplasm] (Homo sapiens)
CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Homo sapiens)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DCAF5 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DCAF5 [nucleoplasm] (Homo sapiens)
COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DCAF5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DCAF5 [nucleoplasm] (Homo sapiens)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DCAF5 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DCAF5 [nucleoplasm] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DCAF5 [nucleoplasm] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DCAF5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96JK2 DCAF5
Gene Names
DCAF5, BCRG2, KIAA1824, WDR22
Chain
chain:1-942
Reference Genes
BioGPS Gene:8816 DCAF5
COSMIC (genes):DCAF5 DCAF5
CTD Gene:8816 DCAF5
dbSNP Gene:8816 DCAF5
ENSEMBL:ENSG00000139990 DCAF5
HGNC:20224 DCAF5
Monarch:8816 DCAF5
NCBI Gene:8816 DCAF5
OMIM:603812 DCAF5
UCSC:Q96JK2 DCAF5
Reference Transcript
RefSeq:NM_003861.2 DCAF5
RefSeq:XM_017021735.1 DCAF5
RefSeq:XM_017021734.1 DCAF5
RefSeq:NM_001284207.1 DCAF5
RefSeq:NM_001284206.1 DCAF5
Other Identifiers
11725648_a_at
11725649_s_at
11725650_s_at
11725651_a_at
11760781_at
1554558_PM_at
1554558_at
16794220
224696_PM_s_at
224696_s_at
224697_PM_at
224697_at
224703_PM_at
224703_at
227251_PM_at
227251_at
3569925
3569927
3569928
3569929
3569930
3569931
3569934
3569935
3569940
3569943
3569944
3569945
3569946
3569947
3569950
3569951
3569952
3569953
3569954
3569955
3569967
3569968
3569969
3569970
3569971
43962_at
56454_at
62461_at
7979849
85361_at
8816
A_23_P117346
A_23_P352684
A_24_P940396
A_33_P3384667
GE80034
GO:0005515
GO:0005654
GO:0005737
GO:0016567
GO:0045717
GO:0080008
HMNXSV003029870
HMNXSV003043414
Hs.284294.0.S1_3p_at
Hs.284294.0.S2_3p_a_at
Hs.284294.1.S1_3p_at
Hs2.284294.1.S1_3p_at
ILMN_1735402
PH_hs_0034222
TC14001256.hg
Participates
as a member of
DCAF protein [nucleoplasm] (Homo sapiens)
Inferred To
DCAF5 [nucleoplasm]
(Bos taurus)
DCAF5 [nucleoplasm]
(Caenorhabditis elegans)
DCAF5 [nucleoplasm]
(Canis familiaris)
DCAF5 [nucleoplasm]
(Dictyostelium discoideum)
DCAF5 [nucleoplasm]
(Gallus gallus)
DCAF5 [nucleoplasm]
(Sus scrofa)
dcaf5 [nucleoplasm]
(Danio rerio)
iqw1 [nucleoplasm]
(Schizosaccharomyces pombe)
CG2112 [nucleoplasm]
(Drosophila melanogaster)
Dcaf5 [nucleoplasm]
(Mus musculus)
Dcaf5 [nucleoplasm]
(Rattus norvegicus)
Cross References
ENSEMBL
ENSP00000341351
,
ENSP00000451551
,
ENST00000341516
,
ENST00000554215
,
ENSP00000452052
,
ENST00000557386
,
ENST00000556847
,
ENSP00000451845
OpenTargets
ENSG00000139990
HPA
ENSG00000139990-DCAF5
PRO
Q96JK2
Pharos - Targets
Q96JK2
PDB
3I89
,
8TL6
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P26358 DNMT1
2
DNMT1 [nucleoplasm]
(R-HSA-212181)
monoSUMO1-K-DNMT1 [nucleoplasm]
(R-HSA-4655353)
0.576
5
UniProt:P10809 HSPD1
6
HSPD1(1-573) [cytosol]
(R-HSA-1267989)
HSPD1(1-573) [mitochondrial intermembrane space]
(R-HSA-1267963)
HSPD1(1-26) [mitochondrial matrix]
(R-HSA-8986171)
HSPD1(1-573) [mitochondrial inner membrane]
(R-HSA-1299442)
HSPD1 [mitochondrial inner membrane]
(R-HSA-1299455)
HSPD1 [mitochondrial matrix]
(R-HSA-1299448)
0.527
4
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.527
4
UniProt:P62263 RPS14
2
RPS14 [cytosol]
(R-HSA-72333)
RPS14 [nucleoplasm]
(R-HSA-6790669)
0.527
2
UniProt:Q6IPR3 TYW3
1
TYW3 [cytoplasm]
(R-HSA-6782888)
0.527
2
UniProt:Q9BQB4 SOST
1
SOST [extracellular region]
(R-HSA-3769322)
0.527
2
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