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PXLP-K754-GLDC [mitochondrial matrix]
Stable Identifier
R-HSA-5693966
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
Glycine dehydrogenase, GCSP_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Glyoxylate metabolism and glycine degradation (Homo sapiens)
Glycine degradation (Homo sapiens)
PXLP-K754-GLDC dimer decarboxylates Gly (Homo sapiens)
PXLP-K754-GLDC dimer [mitochondrial matrix] (Homo sapiens)
PXLP-K754-GLDC [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23378 GLDC
Gene Names
GLDC, GCSP
Chain
transit peptide:1-35, chain:36-1020
Reference Genes
BioGPS Gene:2731 GLDC
COSMIC (genes):GLDC GLDC
CTD Gene:2731 GLDC
dbSNP Gene:2731 GLDC
ENSEMBL:ENSG00000178445 GLDC
HGNC:4313 GLDC
KEGG:hsa:2731 GLDC
Monarch:2731 GLDC
NCBI Gene:2731 GLDC
OMIM:238300 GLDC
UCSC:P23378 GLDC
Reference Transcript
RefSeq:NM_000170.2 GLDC
Other Identifiers
11728466_a_at
11756165_s_at
17092268
204836_PM_at
204836_at
2728313
2728314
2728315
2728316
2728318
2728319
2728321
2728322
2728323
2728324
2728325
2728326
2728327
2728328
2728329
2728330
2728332
2728333
2728334
2728335
2728336
2728338
2728339
2731
3197956
3197957
3197958
3197959
3197960
3197962
3197963
3197967
3197968
3197969
3197970
3197971
3197972
3197975
3197976
3197977
3197978
3197979
3197980
3197981
3197982
3197985
3197986
3197987
3197988
3197989
3197994
3197995
3197996
3197997
3197998
3197999
3198000
3198001
3198002
3198004
3198005
3198006
3198007
3198008
3198009
3198011
3198014
3198015
3198016
3198017
35192_at
53483_at
8160024
A_23_P123596
GE57446
GE712664
GO:0003824
GO:0004375
GO:0005654
GO:0005739
GO:0005759
GO:0005886
GO:0005960
GO:0006520
GO:0006544
GO:0006546
GO:0009055
GO:0009116
GO:0016491
GO:0016594
GO:0016829
GO:0019464
GO:0030170
GO:0036255
GO:0042803
GO:0043226
GO:0055086
GO:0070280
GO:1901135
GO:1903442
GO:1990830
HMNXSV003039357
ILMN_1806754
M64590_at
PH_hs_0029223
TC09000899.hg
g4504012_3p_at
Participates
as a component of
PXLP-K754-GLDC dimer [mitochondrial matrix] (Homo sapiens)
Inferred To
GLDC [mitochondrial matrix]
(Bos taurus)
GLDC [mitochondrial matrix]
(Canis familiaris)
GLDC [mitochondrial matrix]
(Sus scrofa)
PXLP-K754-GLDC [mitochondrial matrix]
(Gallus gallus)
gcv2 [mitochondrial matrix]
(Schizosaccharomyces pombe)
gcvP [mitochondrial matrix]
(Dictyostelium discoideum)
Gldc [mitochondrial matrix]
(Drosophila melanogaster)
Gldc [mitochondrial matrix]
(Mus musculus)
Gldc [mitochondrial matrix]
(Rattus norvegicus)
gldc [mitochondrial matrix]
(Danio rerio)
gldc-1 [mitochondrial matrix]
(Caenorhabditis elegans)
GCV2 [mitochondrial matrix]
(Saccharomyces cerevisiae)
Modified Residues
Name
N6-pyridoxal phosphate-L-lysine at 754
Coordinate
754
PsiMod Name
N6-pyridoxal phosphate-L-lysine [MOD:00128]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.
Cross References
ENSEMBL
ENSP00000370737
,
ENSG00000178445
,
ENST00000321612
OpenTargets
ENSG00000178445
GeneCards
GLDC
HPA
ENSG00000178445-GLDC
PRO
P23378
Pharos - Targets
P23378
Orphanet
GLDC
HMDB Protein
HMDBP00795
PDB
6I33
,
6I35
,
6I34
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UHN1 POLG2
1
POLG2(?-485) [mitochondrial matrix]
(R-HSA-1592214)
0.527
3
UniProt:Q9BQB4 SOST
1
SOST [extracellular region]
(R-HSA-3769322)
0.527
2
UniProt:P14324 FDPS
1
FDPS [cytosol]
(R-HSA-981566)
0.527
2
UniProt:O14561 NDUFAB1
3
NDUFAB1 [mitochondrial inner membrane]
(R-HSA-163925)
octanoyl-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-9857608)
Mal-PPANT-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-8934586)
0.527
2
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