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p-3S,2T-LRP5 [plasma membrane]
Stable Identifier
R-HSA-1458905
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-5S-LRP5, p5S/T-LRP5
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI (Homo sapiens)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
p5S/T-LRP5/6 [plasma membrane] (Homo sapiens)
p-3S,2T-LRP5 [plasma membrane] (Homo sapiens)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Homo sapiens)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
p5S/T-LRP5/6 [plasma membrane] (Homo sapiens)
p-3S,2T-LRP5 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75197 LRP5
Gene Names
LRP5, LR3, LRP7
Chain
signal peptide:1-31, chain:32-1615
Reference Genes
BioGPS Gene:4041 LRP5
COSMIC (genes):LRP5 LRP5
CTD Gene:4041 LRP5
dbSNP Gene:4041 LRP5
ENSEMBL:ENSG00000162337 LRP5
ENSEMBL_homo_sapiens_GENE:ENSG00000162337.12 LRP5
HGNC:6697 LRP5
KEGG Gene (Homo sapiens):4041 LRP5
Monarch:4041 LRP5
NCBI Gene:4041 LRP5
OMIM:603506 LRP5
UCSC:O75197 LRP5
Reference Transcript
RefSeq:NM_001291902.1 LRP5
RefSeq:NM_002335.3 LRP5
Other Identifiers
11727159_a_at
16728066
209468_PM_at
209468_at
3337517
3337518
3337539
3337548
3337549
3337550
3337561
3337565
3337574
3337576
3337578
3337579
3337581
3337582
3337588
3337589
3337590
3337592
3337595
3337598
3337599
3337600
3337606
3337609
3337610
3337611
3955653
3955654
4041
41831_at
7942007
A_14_P104736
A_23_P1505
GE54706
GO:0000278
GO:0001702
GO:0001944
GO:0002053
GO:0002076
GO:0002376
GO:0003013
GO:0005515
GO:0005783
GO:0005886
GO:0005975
GO:0006007
GO:0006351
GO:0006355
GO:0006629
GO:0006865
GO:0006897
GO:0007155
GO:0008078
GO:0008203
GO:0008217
GO:0008284
GO:0009952
GO:0010467
GO:0012501
GO:0015026
GO:0016020
GO:0016055
GO:0016192
GO:0017147
GO:0023052
GO:0030154
GO:0033687
GO:0033690
GO:0035019
GO:0035108
GO:0035426
GO:0036211
GO:0042074
GO:0042632
GO:0042733
GO:0042813
GO:0042981
GO:0043226
GO:0043235
GO:0043434
GO:0045600
GO:0045668
GO:0045669
GO:0045840
GO:0045893
GO:0045944
GO:0046849
GO:0048514
GO:0048539
GO:0048856
GO:0048870
GO:0060033
GO:0060042
GO:0060070
GO:0060089
GO:0060348
GO:0060349
GO:0060444
GO:0060603
GO:0060612
GO:0060764
GO:0060856
GO:0061178
GO:0061298
GO:0061299
GO:0061304
GO:0071901
GO:0098609
GO:0110135
GO:0140014
GO:1902262
GO:1990851
GO:1990909
GO:1990963
HMNXSV003010807
ILMN_1702775
ILMN_2075892
PH_hs_0000640
TC11000707.hg
g3582144_3p_at
Participates
as a member of
p5S/T-LRP5/6 [plasma membrane] (Homo sapiens)
Other forms of this molecule
LRP5 D666_L809del [plasma membrane]
LRP5 [early endosome membrane]
p-5S,5T-LRP5 [plasma membrane]
LRP5 [plasma membrane]
Inferred To
phospho-arr [plasma membrane]
(Drosophila melanogaster)
phospho-LRP5 [plasma membrane]
(Bos taurus)
phospho-LRP5 [plasma membrane]
(Canis familiaris)
phospho-LRP5 [plasma membrane]
(Sus scrofa)
phospho-LRP6 [plasma membrane]
(Danio rerio)
phospho-Lrp5 [plasma membrane]
(Mus musculus)
phospho-Lrp5 [plasma membrane]
(Rattus norvegicus)
phospho-p-3S,2T-LRP5 [plasma membrane]
(Caenorhabditis elegans)
Modified Residues
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001278831.1
,
NP_002326.2
OpenTargets
ENSG00000162337
HPA
ENSG00000162337-LRP5
GeneCards
O75197
Ensembl
ENSP00000294304
,
ENST00000294304
,
ENSG00000162337
PRO
O75197
Pharos - Targets
O75197
Orphanet
16372
HMDB Protein
HMDBP07786
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BQB4 SOST
1
SOST [extracellular region]
(R-HSA-3769322)
0.669
3
UniProt:Q9H5K3 POMK
1
POMK [endoplasmic reticulum membrane]
(R-HSA-8879120)
0.527
2
UniProt:Q8J025 APCD1
0.524
3
UniProt:Q6IMN6 CAPR2
0.524
3
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