Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Sost [extracellular region]
Stable Identifier
R-MMU-3769322
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
extracellular region
Synonyms
SOST, Q99P68
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Signaling by WNT (Mus musculus)
TCF dependent signaling in response to WNT (Mus musculus)
Negative regulation of TCF-dependent signaling by WNT ligand antagonists (Mus musculus)
SOST binds LRP5/6 (Mus musculus)
SOST:LRP5/6 [plasma membrane] (Mus musculus)
Sost [extracellular region] (Mus musculus)
Sost [extracellular region] (Mus musculus)
External Reference Information
External Reference
UniProt:Q99P68
Gene Names
Sost
Reference Genes
BioGPS Gene:74499 Sost
ENSEMBL:ENSMUSG00000001494
KEGG:mmu:74499 Sost
Monarch:74499 Sost
NCBI Gene:74499 Sost
UCSC:Q99P68 Sost
Reference Transcript
RefSeq:NM_024449.6 Sost
Other Identifiers
10391508
1421245_at
1450179_at
17269980
4422218
4434218
4484588
4532354
4563948
4626713
4706154
4707416
5227148
5565248
74499
A_51_P213870
A_52_P347898
GE41761
GO:0001503
GO:0005515
GO:0005576
GO:0005615
GO:0005794
GO:0006355
GO:0008201
GO:0009612
GO:0016055
GO:0030178
GO:0030279
GO:0030509
GO:0030514
GO:0031333
GO:0032991
GO:0036122
GO:0045893
GO:0060070
GO:0071374
GO:0090090
GO:0098772
GO:0140297
GO:0140678
ILMN_1253415
mMC006870
Participates
as an input of
SOST binds LRP5/6 (Mus musculus)
as a component of
SOST:LRP5/6 [plasma membrane] (Mus musculus)
Inferred From
SOST [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_077769.4
ENSEMBL
ENSMUST00000001534
,
ENSMUSG00000001494
,
ENSMUSP00000001534
PRO
Q99P68
GlyGen
Q99P68
MGI
1921749
PDB
2KD3
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text