SOST is a secreted antagonist of WNT signaling that acts by binding to LRP5/6 (Li et al, 2005; Semenov et al, 2005; Veverka et al, 2005). Binding of SOST requires the first two YWTD EGF repeats of LRP5/6 and appears to inhibit WNT signaling by preventing the formation of the LRP5/6:FZD receptor complex (Li et al, 2005; Semenov et al, 2005).
Harris, SE, Li, X, Kang, H, Liu, W, Zhang, Y, Zhang, J, Liu, P, Wu, D
He, X, Tamai, K, Semënov, M
Robinson, MK, Paszty, C, Qian, X, Muzylak, M, Gong, J, Zhang, L, Slocombe, PM, Taylor, RJ, Greenslade, K, Carr, MD, Mulloy, B, Muskett, FW, Henry, AJ, Veverka, V, Moore, A, Ventom, A
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