SOST binds LRP5/6

Stable Identifier
R-HSA-3769397
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
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SOST binds LRP5/6
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SOST is a secreted antagonist of WNT signaling that acts by binding to LRP5/6 (Li et al, 2005; Semenov et al, 2005; Veverka et al, 2005). Binding of SOST requires the first two YWTD EGF repeats of LRP5/6 and appears to inhibit WNT signaling by preventing the formation of the LRP5/6:FZD receptor complex (Li et al, 2005; Semenov et al, 2005).

Literature References
PubMed ID Title Journal Year
15908424 SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

Semënov, M, Tamai, K, He, X

J. Biol. Chem. 2005
15778503 Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

Li, X, Zhang, Y, Kang, H, Liu, W, Liu, P, Zhang, J, Harris, SE, Wu, D

J. Biol. Chem. 2005
19208630 Characterization of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation

Veverka, V, Henry, AJ, Slocombe, PM, Ventom, A, Mulloy, B, Muskett, FW, Muzylak, M, Greenslade, K, Moore, A, Zhang, L, Gong, J, Qian, X, Paszty, C, Taylor, RJ, Robinson, MK, Carr, MD

J. Biol. Chem. 2009
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Orthologous Events
SOST binds LRP5/6 (Bos taurus)
SOST binds LRP5/6 (Canis familiaris)
SOST binds LRP5/6 (Mus musculus)
SOST binds LRP5/6 (Rattus norvegicus)
SOST binds LRP5/6 (Sus scrofa)
Authored
Rothfels, K  (2013-05-30)
Reviewed
Rajakulendran, N  (2014-01-22)
van Amerongen, R  (2014-02-15)
Kikuchi, A  (2014-04-22)
Created
Rothfels, K  (2013-06-20)