Reactome | SOST binds LRP5/6

SOST binds LRP5/6

Stable Identifier

R-HSA-3769397

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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SOST is a secreted antagonist of WNT signaling that acts by binding to LRP5/6 (Li et al, 2005; Semenov et al, 2005; Veverka et al, 2005). Binding of SOST requires the first two YWTD EGF repeats of LRP5/6 and appears to inhibit WNT signaling by preventing the formation of the LRP5/6:FZD receptor complex (Li et al, 2005; Semenov et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
15778503	Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling Li, X, Zhang, Y, Kang, H, Liu, W, Liu, P, Zhang, J, Harris, SE, Wu, D	J. Biol. Chem.	2005
15908424	SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor Semënov, M, Tamai, K, He, X	J. Biol. Chem.	2005
19208630	Characterization of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation Veverka, V, Henry, AJ, Slocombe, PM, Ventom, A, Mulloy, B, Muskett, FW, Muzylak, M, Greenslade, K, Moore, A, Zhang, L, Gong, J, Qian, X, Paszty, C, Taylor, RJ, Robinson, MK, Carr, MD	J. Biol. Chem.	2009