SOST is a secreted antagonist of WNT signaling that acts by binding to LRP5/6 (Li et al, 2005; Semenov et al, 2005; Veverka et al, 2005). Binding of SOST requires the first two YWTD EGF repeats of LRP5/6 and appears to inhibit WNT signaling by preventing the formation of the LRP5/6:FZD receptor complex (Li et al, 2005; Semenov et al, 2005).
Semënov, M, Tamai, K, He, X
Li, X, Zhang, Y, Kang, H, Liu, W, Liu, P, Zhang, J, Harris, SE, Wu, D
Veverka, V, Henry, AJ, Slocombe, PM, Ventom, A, Mulloy, B, Muskett, FW, Muzylak, M, Greenslade, K, Moore, A, Zhang, L, Gong, J, Qian, X, Paszty, C, Taylor, RJ, Robinson, MK, Carr, MD
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