Reactome | SLIT2 [extracellular region]

SLIT2 [extracellular region]

Stable Identifier

R-HSA-375997

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

SLIT2(31-1529), Slit homolog 2 protein, SLIT2_HUMAN

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External Reference Information

External Reference

UniProt:O94813 SLIT2

Gene Names

SLIT2, SLIL3

Chain

signal peptide:1-30, chain:31-1529, chain:31-1121, chain:1122-1529

Reference Genes

BioGPS Gene:9353 SLIT2

COSMIC (genes):SLIT2 SLIT2

CTD Gene:9353 SLIT2

dbSNP Gene:9353 SLIT2

ENSEMBL:ENSG00000145147 SLIT2

ENSEMBL:ENSG00000145147.20 SLIT2

HGNC:11086 SLIT2

KEGG Gene (Homo sapiens):9353 SLIT2

Monarch:9353 SLIT2

NCBI Gene:9353 SLIT2

OMIM:603746 SLIT2

UCSC:O94813 SLIT2

Reference Transcript

Other Identifiers

11721399_a_at

16965377

209897_PM_s_at

209897_s_at

228850_PM_s_at

228850_s_at

2720585

2720586

2720587

2720588

2720589

2720594

2720595

2720598

2720624

2720630

2720633

2720634

2720636

2720637

2720640

2720641

2720642

2720644

2720645

2720646

2720648

2720650

2720651

2720652

2720653

2720655

2720656

2720658

2720659

2720660

2720662

2720664

2720666

2720667

2720672

2720673

2720674

2720675

2720676

2720679

2720681

2720682

2720684

2720685

2720686

2720687

2720688

2720689

2720690

2720691

2720692

2720693

39634_at

56940_g_at

8094301

9353

A_14_P101304

A_14_P105118

A_14_P118390

A_23_P144348

GE54526

GO:0001657

GO:0001933

GO:0002042

GO:0002376

GO:0002689

GO:0003013

GO:0003180

GO:0003184

GO:0005095

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0006935

GO:0007010

GO:0007399

GO:0007411

GO:0008045

GO:0008201

GO:0010593

GO:0010596

GO:0012501

GO:0014912

GO:0016020

GO:0016043

GO:0021836

GO:0021972

GO:0022414

GO:0023052

GO:0030154

GO:0030308

GO:0030336

GO:0030837

GO:0031290

GO:0032870

GO:0035385

GO:0036211

GO:0042802

GO:0042803

GO:0043065

GO:0043116

GO:0043226

GO:0043237

GO:0043394

GO:0048495

GO:0048754

GO:0048846

GO:0048856

GO:0048870

GO:0050772

GO:0050919

GO:0050929

GO:0051058

GO:0051414

GO:0060412

GO:0061364

GO:0065003

GO:0070062

GO:0070100

GO:0071504

GO:0071672

GO:0071676

GO:0090024

GO:0090027

GO:0090260

GO:0090288

GO:0098772

HMNXSV003037566

Hs.110373.0.S1_3p_at

ILMN_1676449

PH_hs_0002574

TC04000158.hg

g4151204_3p_a_at

Participates

as a component of

as an input of

as a member of

as an output of

SLIT2 gene expression is stimulated by ISL1 (Homo sapiens)

Other forms of this molecule

SLIT2(31-1121) [extracellular region]

SLIT2(1122-1529) [extracellular region]

Inferred To

Toll-6 [extracellular region] (Drosophila melanogaster)

sli [extracellular region] (Drosophila melanogaster)

SLIT2 [extracellular region] (Bos taurus)

SLIT2 [extracellular region] (Canis familiaris)

SLIT2 [extracellular region] (Danio rerio)

SLIT2 [extracellular region] (Gallus gallus)

SLIT2 [extracellular region] (Sus scrofa)

Slit2 [extracellular region] (Mus musculus)

Homologues of SLIT2 [extracellular region] (Drosophila melanogaster)

slt-1 [extracellular region] (Caenorhabditis elegans)

slit2 [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_001276065.1, NP_004778.1, NP_001276064.1

OpenTargets

ENSG00000145147

HPA

ENSG00000145147-SLIT2

GeneCards

O94813

Ensembl

ENST00000504154, ENSG00000145147, ENST00000503837, ENSP00000427548, ENST00000503823, ENSP00000422261, ENSP00000422591

PRO

O94813

Pharos - Targets

O94813

Orphanet

25748

PDB

2V70, 2V9T, 2WFH, 2V9S

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O94813 SLIT2	3	SLIT2(31-1121) [extracellular region] (R-HSA-426409) SLIT2(1122-1529) [extracellular region] (R-HSA-426412) SLIT2 [extracellular region] (R-HSA-375997)	0.558	2
UniProt:Q9Y6N7 ROBO1	3	p-Y1073-ROBO1 [plasma membrane] (R-HSA-375979) PolyUb-ROBO1 [plasma membrane] (R-HSA-8986095) ROBO1 [plasma membrane] (R-HSA-204361)	0.558	2