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p-Y1073-ROBO1 [plasma membrane]
Stable Identifier
R-HSA-375979
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Phosphorylated ROBO1
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Role of ABL in ROBO-SLIT signaling (Homo sapiens)
Phosphorylation of ROBO1 by ABL kinase (Homo sapiens)
SLIT2:p-Y1073-ROBO1:ABL [plasma membrane] (Homo sapiens)
p-Y1073-ROBO1:SLIT2 [plasma membrane] (Homo sapiens)
p-Y1073-ROBO1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y6N7 ROBO1
Gene Names
ROBO1, DUTT1
Chain
signal peptide:1-25, chain:26-1651
Reference Genes
BioGPS Gene:6091 ROBO1
COSMIC (genes):ROBO1 ROBO1
CTD Gene:6091 ROBO1
dbSNP Gene:6091 ROBO1
ENSEMBL:ENSG00000169855 ROBO1
ENSEMBL:ENSG00000169855.21 ROBO1
HGNC:10249 ROBO1
KEGG Gene (Homo sapiens):6091 ROBO1
Monarch:6091 ROBO1
NCBI Gene:6091 ROBO1
OMIM:602430 ROBO1
UCSC:Q9Y6N7 ROBO1
Reference Transcript
RefSeq:XM_006713277.2 ROBO1
RefSeq:XM_017006983.1 ROBO1
RefSeq:NM_001145845.1 ROBO1
RefSeq:NM_002941.3 ROBO1
RefSeq:NM_133631.3 ROBO1
Other Identifiers
11725495_a_at
11751560_a_at
11758227_s_at
16956386
213194_PM_at
213194_at
2683764
2683766
2683768
2683769
2683770
2683771
2683772
2683773
2683774
2683781
2683785
2683786
2683790
2683791
2683792
2683795
2683797
2683798
2683799
2683800
2683801
2683804
2683805
2683806
2683807
2683813
2683816
2683817
2683818
2683821
2683850
2683864
2683865
2683866
2683867
2683868
2683869
2683870
2683871
2683877
2683902
2683903
2683963
2683964
2683993
32944_at
42644_at
55461_at
6091
8088919
85473_at
A_23_P80503
A_24_P77432
GE63242
GO:0002042
GO:0003148
GO:0003180
GO:0003184
GO:0003272
GO:0005515
GO:0005737
GO:0005886
GO:0006919
GO:0006935
GO:0007155
GO:0007156
GO:0007399
GO:0007411
GO:0008046
GO:0009986
GO:0010628
GO:0010629
GO:0016020
GO:0016199
GO:0021836
GO:0023052
GO:0030154
GO:0030275
GO:0030336
GO:0030424
GO:0030949
GO:0033116
GO:0033600
GO:0035025
GO:0035385
GO:0035481
GO:0035904
GO:0036211
GO:0042802
GO:0042995
GO:0043005
GO:0043226
GO:0043406
GO:0048856
GO:0048870
GO:0050772
GO:0050925
GO:0060089
GO:0060412
GO:0070100
GO:1900748
HMNXSV003043301
Hs.301198.0.S2_3p_at
ILMN_1666468
ILMN_1710723
ILMN_1806790
PH_hs_0026807
TC03001570.hg
Participates
as a component of
p-Y1073-ROBO1:SLIT2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
PolyUb-ROBO1 [plasma membrane]
ROBO1 [plasma membrane]
Inferred To
phospho-DIP-alpha [plasma membrane]
(Drosophila melanogaster)
phospho-DIP-gamma [plasma membrane]
(Drosophila melanogaster)
phospho-DIP-delta [plasma membrane]
(Drosophila melanogaster)
phospho-robo1 [plasma membrane]
(Drosophila melanogaster)
phospho-p-Y1073-ROBO1 [plasma membrane]
(Danio rerio)
phospho-ROBO1 [plasma membrane]
(Bos taurus)
phospho-DIP-eta [plasma membrane]
(Drosophila melanogaster)
phospho-DIP-lambda [plasma membrane]
(Drosophila melanogaster)
phospho-Nrg [plasma membrane]
(Drosophila melanogaster)
phospho-rig-5 [plasma membrane]
(Caenorhabditis elegans)
phospho-DIP-kappa [plasma membrane]
(Drosophila melanogaster)
phospho-DIP-zeta [plasma membrane]
(Drosophila melanogaster)
phospho-DIP-beta [plasma membrane]
(Drosophila melanogaster)
phospho-CT35293 [plasma membrane]
(Drosophila melanogaster)
phospho-Robo1 [plasma membrane]
(Mus musculus)
phospho-Lac [plasma membrane]
(Drosophila melanogaster)
phospho-CT35363 [plasma membrane]
(Drosophila melanogaster)
phospho-fipi [plasma membrane]
(Drosophila melanogaster)
Homologues of p-Y1073-ROBO1 [plasma membrane]
(Drosophila melanogaster)
phospho-robo2 [plasma membrane]
(Drosophila melanogaster)
Modified Residues
Name
O4'-phospho-L-tyrosine at 1073
Coordinate
1073
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_002932.1
,
NP_598334.2
,
XP_016862472.1
,
XP_006713340.1
,
NP_001139317.1
OpenTargets
ENSG00000169855
GeneCards
Q9Y6N7
HPA
ENSG00000169855-ROBO1
Ensembl
ENSP00000417992
,
ENSP00000420321
,
ENST00000464233
,
ENST00000495273
,
ENST00000467549
,
ENSP00000420637
,
ENSG00000169855
PRO
Q9Y6N7
Pharos - Targets
Q9Y6N7
Orphanet
25795
PDB
2EO9
,
2V9R
,
6A78
,
3WIH
,
5O5I
,
5OPE
,
6A77
,
5O5G
,
2V9Q
,
6A79
,
4HLJ
,
2V9T
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75044 SRGAP2
1
SRGAP2 [cytosol]
(R-HSA-195131)
0.558
3
UniProt:O94813 SLIT2
3
SLIT2(31-1121) [extracellular region]
(R-HSA-426409)
SLIT2(1122-1529) [extracellular region]
(R-HSA-426412)
SLIT2 [extracellular region]
(R-HSA-375997)
0.558
2
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