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SLIT2 binds Dystroglycan
Stable Identifier
R-HSA-9010872
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
SLIT2 binds Dystroglycan (Homo sapiens)
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SLIT2 binds to dystroglycan (DAG1). The interaction involves the C-terminal region of human SLIT2. The species origin of the DAG1 construct was not specified and is assumed to be human. Dystroglycan is required for proper SLIT2 localization within the basement membrane and the floor plate. Dystroglycan glycosylation, mediated at least in part by B4GAT1 (B3GNT1) and ISPD, is likely required for its interaction with SLIT2, but it has not been annotated. Mice mutant for B4gat1, Ispd or Dag1 have axon guidance defects similar to those observed in Slit or Robo mutant mice (Wright et al. 2012).
Literature References
PubMed ID
Title
Journal
Year
23217742
Dystroglycan organizes axon guidance cue localization and axonal pathfinding
Ma, L
,
Leung, H
,
Lyon, KA
,
Leahy, DJ
,
Wright, KM
,
Ginty, DD
Neuron
2012
Participants
Input
Dystroglycan [plasma membrane]
(Homo sapiens)
SLIT2 [extracellular region]
(Homo sapiens)
Output
SLIT2:Dystroglycan [plasma membrane]
(Homo sapiens)
Participates
as an event of
Regulation of expression of SLITs and ROBOs (Homo sapiens)
Orthologous Events
SLIT2 binds Dystroglycan (Bos taurus)
SLIT2 binds Dystroglycan (Caenorhabditis elegans)
SLIT2 binds Dystroglycan (Canis familiaris)
SLIT2 binds Dystroglycan (Drosophila melanogaster)
SLIT2 binds Dystroglycan (Gallus gallus)
SLIT2 binds Dystroglycan (Mus musculus)
SLIT2 binds Dystroglycan (Sus scrofa)
Authored
Orlic-Milacic, M (2017-06-23)
Reviewed
Jaworski, A (2017-07-31)
Created
Orlic-Milacic, M (2017-06-28)
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