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SLIT2(31-1121) [extracellular region]
Stable Identifier
R-HSA-426409
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Slit2-N, N-terminal fragment of Slit-2, membrane associated
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Glypican-1 (GPC1) binds SLIT2 (Homo sapiens)
SLIT2,SLIT2 cleavage fragments [extracellular region] (Homo sapiens)
SLIT2(31-1121) [extracellular region] (Homo sapiens)
SLIT2,SLIT2 cleavage fragments:GPC1:HSPG [plasma membrane] (Homo sapiens)
SLIT2,SLIT2 cleavage fragments [extracellular region] (Homo sapiens)
SLIT2(31-1121) [extracellular region] (Homo sapiens)
Proteolytic processing of SLIT (Homo sapiens)
SLIT2(31-1121) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:O94813 SLIT2
Gene Names
SLIT2, SLIL3
Chain
signal peptide:1-30, chain:31-1529, chain:31-1121, chain:1122-1529
Reference Genes
BioGPS Gene:9353 SLIT2
COSMIC (genes):SLIT2 SLIT2
CTD Gene:9353 SLIT2
dbSNP Gene:9353 SLIT2
ENSEMBL:ENSG00000145147 SLIT2
ENSEMBL_homo_sapiens_GENE:ENSG00000145147.20 SLIT2
HGNC:11086 SLIT2
KEGG Gene (Homo sapiens):9353 SLIT2
Monarch:9353 SLIT2
NCBI Gene:9353 SLIT2
OMIM:603746 SLIT2
UCSC:O94813 SLIT2
Reference Transcript
RefSeq:NM_001289135.2 SLIT2
RefSeq:NM_004787.3 SLIT2
RefSeq:NM_001289136.2 SLIT2
Other Identifiers
11721399_a_at
16965377
209897_PM_s_at
209897_s_at
228850_PM_s_at
228850_s_at
2720585
2720586
2720587
2720588
2720589
2720594
2720595
2720598
2720624
2720630
2720633
2720634
2720636
2720637
2720640
2720641
2720642
2720644
2720645
2720646
2720648
2720650
2720651
2720652
2720653
2720655
2720656
2720658
2720659
2720660
2720662
2720664
2720666
2720667
2720672
2720673
2720674
2720675
2720676
2720679
2720681
2720682
2720684
2720685
2720686
2720687
2720688
2720689
2720690
2720691
2720692
2720693
39634_at
56940_g_at
8094301
9353
A_14_P101304
A_14_P105118
A_14_P118390
A_23_P144348
GE54526
GO:0001657
GO:0001933
GO:0002042
GO:0002376
GO:0002689
GO:0003013
GO:0003180
GO:0003184
GO:0005095
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0006935
GO:0007010
GO:0007399
GO:0007411
GO:0008045
GO:0008201
GO:0010593
GO:0010596
GO:0012501
GO:0014912
GO:0016020
GO:0016043
GO:0021836
GO:0021972
GO:0022414
GO:0023052
GO:0030154
GO:0030308
GO:0030336
GO:0030837
GO:0031290
GO:0032870
GO:0035385
GO:0036211
GO:0042802
GO:0042803
GO:0043065
GO:0043116
GO:0043226
GO:0043237
GO:0043394
GO:0048495
GO:0048754
GO:0048846
GO:0048856
GO:0048870
GO:0050772
GO:0050919
GO:0050929
GO:0051058
GO:0051414
GO:0060412
GO:0061364
GO:0065003
GO:0070062
GO:0070100
GO:0071504
GO:0071672
GO:0071676
GO:0090024
GO:0090027
GO:0090260
GO:0090288
GO:0098772
HMNXSV003037566
Hs.110373.0.S1_3p_at
ILMN_1676449
PH_hs_0002574
TC04000158.hg
g4151204_3p_a_at
Participates
as an output of
Proteolytic processing of SLIT (Homo sapiens)
as a member of
SLIT2,SLIT2 cleavage fragments [extracellular region] (Homo sapiens)
Other forms of this molecule
SLIT2(1122-1529) [extracellular region]
SLIT2 [extracellular region]
Inferred To
Toll-6 [extracellular region]
(Drosophila melanogaster)
sli [extracellular region]
(Drosophila melanogaster)
Homologues of SLIT2(31-1121) [extracellular region]
(Drosophila melanogaster)
SLIT2 [extracellular region]
(Bos taurus)
SLIT2 [extracellular region]
(Canis familiaris)
SLIT2 [extracellular region]
(Sus scrofa)
Slit2 [extracellular region]
(Mus musculus)
slt-1 [extracellular region]
(Caenorhabditis elegans)
SLIT2(31-1121) [extracellular region]
(Gallus gallus)
Cross References
RefSeq
NP_004778.1
,
NP_001276065.1
,
NP_001276064.1
OpenTargets
ENSG00000145147
GeneCards
O94813
HPA
ENSG00000145147-SLIT2
Ensembl
ENST00000504154
,
ENST00000503837
,
ENSP00000422261
,
ENSP00000422591
,
ENSP00000427548
,
ENSG00000145147
,
ENST00000503823
PRO
O94813
Pharos - Targets
O94813
PDB
2V9T
,
2V70
,
2V9S
,
2WFH
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O94813 SLIT2
3
SLIT2(31-1121) [extracellular region]
(R-HSA-426409)
SLIT2(1122-1529) [extracellular region]
(R-HSA-426412)
SLIT2 [extracellular region]
(R-HSA-375997)
0.558
2
UniProt:Q9Y6N7 ROBO1
3
p-Y1073-ROBO1 [plasma membrane]
(R-HSA-375979)
PolyUb-ROBO1 [plasma membrane]
(R-HSA-8986095)
ROBO1 [plasma membrane]
(R-HSA-204361)
0.558
2
UniProt:P59665 DEFA1
9
DEFA1(65-94) [azurophil granule lumen]
(R-HSA-1470053)
omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region]
(R-HSA-1972397)
DEFA1(65-94) [extracellular region]
(R-HSA-1462022)
DEFA1(66-94) [azurophil granule lumen]
(R-HSA-1470038)
DEFA1(66-94) [extracellular region]
(R-HSA-1461998)
DEFA1(20-65) [Golgi lumen]
(R-HSA-8864970)
DEFA1(66-94) [Golgi lumen]
(R-HSA-975663)
DEFA1(20-94) [Golgi lumen]
(R-HSA-1467282)
DEFA1(1-94) [Golgi lumen]
(R-HSA-1467215)
0.527
2
UniProt:Q9Y2Y8 PRG3
3
PRG3 [specific granule lumen]
(R-HSA-6799555)
PRG3 [extracellular region]
(R-HSA-6806299)
PRG3 [tertiary granule lumen]
(R-HSA-6800905)
0.527
2
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