Reactome | RNF146 [cytosol]

RNF146 [cytosol]

Stable Identifier

R-HSA-3640827

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9NTX7 RNF146

Gene Names

RNF146

Chain

chain:1-359

Reference Genes

BioGPS Gene:81847 RNF146

COSMIC (genes):RNF146 RNF146

CTD Gene:81847 RNF146

dbSNP Gene:81847 RNF146

ENSEMBL:ENSG00000118518 RNF146

HGNC:21336 RNF146

KEGG:hsa:81847 RNF146

Monarch:81847 RNF146

NCBI Gene:81847 RNF146

OMIM:612137 RNF146

UCSC:Q9NTX7 RNF146

Reference Transcript

Participates

as an input of

RNF146 binds RibC-AXIN:TNKS complex (Homo sapiens)

as a component of

as an output of

Ub-RibC-AXIN is degraded by the proteasome (Homo sapiens)

Inferred To

Rnf146 [cytosol] (Drosophila melanogaster)

Rnf146 [cytosol] (Mus musculus)

Rnf146 [cytosol] (Rattus norvegicus)

RNF146B [cytosol] (Bos taurus)

rnf146 [cytosol] (Danio rerio)

rnf146 [cytosol] (Xenopus tropicalis)

RNF146 [cytosol] (Caenorhabditis elegans)

RNF146 [cytosol] (Canis familiaris)

RNF146 [cytosol] (Gallus gallus)

RNF146 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001229776.1, NP_001229777.1, NP_001229781.1, XP_047275344.1, XP_054212475.1, NP_001229778.1, NP_001229779.1, NP_001229773.1, XP_054212478.1, XP_054212477.1, XP_054212474.1, XP_016866826.1, XP_016866825.1, XP_016866827.1, XP_054212476.1, XP_054212479.1, NP_001229775.1, NP_001229774.1, NP_001229780.1, NP_112225.2, XP_011534463.1, XP_054212480.1, XP_054212481.1, XP_011534466.1, XP_016866832.1, XP_016866831.1, XP_011534465.1, XP_011534464.1, XP_016866830.1, XP_006715634.1, XP_016866829.1, XP_047275345.1, XP_016866828.1, XP_047275342.1, XP_047275343.1

OpenTargets

ENSG00000118518

ENSEMBL

ENSP00000357297, ENSP00000477168, ENSP00000476814, ENST00000368314, ENST00000608991, ENST00000610153, ENSG00000118518

HPA

ENSG00000118518-RNF146

GeneCards

RNF146

PRO

Q9NTX7

Pharos - Targets

Q9NTX7

GlyGen

Q9NTX7

PDB

3V3L, 2D8T, 6CF6

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95271 TNKS	1	TNKS [cytosol] (R-HSA-3640825)	0.793	7
UniProt:P09874 PARP1	4	PARP1 [nucleoplasm] (R-HSA-201568) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617)	0.662	5
UniProt:Q9UGN5 PARP2	2	PARP2 [nucleoplasm] (R-HSA-174874) PAR-PARP2 [nucleoplasm] (R-HSA-5651715)	0.643	5
UniProt:P49916 LIG3	1	LIG3 [nucleoplasm] (R-HSA-53789)	0.643	4
UniProt:Q86WJ1 CHD1L	1	CHD1L [nucleoplasm] (R-HSA-5688916)	0.643	4
UniProt:Q5TCQ9 MAGI3			0.59	2
UniProt:Q12959 DLG1	4	DLG1 [plasma membrane] (R-HSA-375977) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593) DLG1 [cytosol] (R-HSA-416332)	0.59	4
UniProt:Q8N6L0 KASH5			0.556	3
UniProt:Q9UGJ1 TUBGCP4	1	TUBGCP4 [cytosol] (R-HSA-379268)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.556	3
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.527	3
UniProt:Q14527 HLTF	1	HLTF [nucleoplasm] (R-HSA-8855007)	0.527	3
UniProt:P18887 XRCC1	1	XRCC1 [nucleoplasm] (R-HSA-67455)	0.527	3
UniProt:Q9H2K2 TNKS2	1	TNKS2 [cytosol] (R-HSA-3640824)	0.527	3
UniProt:Q9Y5B9 SUPT16H	1	SUPT16H [nucleoplasm] (R-HSA-112415)	0.527	3

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