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RNF146 [cytosol]
Stable Identifier
R-HSA-3640827
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP34 deubiquitinates AXIN1,AXIN2 (Homo sapiens)
RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN stability and activity (Homo sapiens)
RNF146 polyubiquitinates PARylated PTEN (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Degradation of AXIN (Homo sapiens)
RNF146 binds RibC-AXIN:TNKS complex (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
RNF146 ubiquitinates ADP-ribosylated AXIN (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
Ub-RibC-AXIN is degraded by the proteasome (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
USP34 deubiquitinates AXIN1,AXIN2 (Homo sapiens)
RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NTX7 RNF146
Gene Names
RNF146
Chain
chain:1-359
Reference Genes
COSMIC (genes):RNF146 RNF146
dbSNP Gene:81847 RNF146
ENSEMBL:ENSG00000118518 RNF146
Participates
as an output of
Ub-RibC-AXIN is degraded by the proteasome (Homo sapiens)
as an input of
RNF146 binds RibC-AXIN:TNKS complex (Homo sapiens)
as a component of
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
Inferred To
Rnf146 [cytosol]
(Drosophila melanogaster)
RNF146B [cytosol]
(Bos taurus)
RNF146 [cytosol]
(Caenorhabditis elegans)
RNF146 [cytosol]
(Canis familiaris)
RNF146 [cytosol]
(Danio rerio)
RNF146 [cytosol]
(Gallus gallus)
RNF146 [cytosol]
(Mus musculus)
RNF146 [cytosol]
(Rattus norvegicus)
RNF146 [cytosol]
(Sus scrofa)
RNF146 [cytosol]
(Xenopus tropicalis)
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95271 TNKS
1
TNKS [cytosol]
(R-HSA-3640825)
0.734
6
UniProt:P09874 PARP1
4
PARP1 [nucleoplasm]
(R-HSA-201568)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
0.662
5
UniProt:Q9UGJ1 TUBGCP4
1
TUBGCP4 [cytosol]
(R-HSA-379268)
0.556
3
UniProt:Q8N6L0 KASH5
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
0.556
3
UniProt:P49916 LIG3
1
LIG3 [nucleoplasm]
(R-HSA-53789)
0.527
3
UniProt:Q9UGN5 PARP2
2
PARP2 [nucleoplasm]
(R-HSA-174874)
PAR-PARP2 [nucleoplasm]
(R-HSA-5651715)
0.527
4
UniProt:Q08945 SSRP1
1
SSRP1 [nucleoplasm]
(R-HSA-65105)
0.527
3
UniProt:Q9Y5B9 SUPT16H
1
SUPT16H [nucleoplasm]
(R-HSA-112415)
0.527
3
UniProt:Q86WJ1 CHD1L
1
CHD1L [nucleoplasm]
(R-HSA-5688916)
0.527
3
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